2010/09/20

Andriol

Composition, structure and packing

Capsules 1 capsule. testosterone undecanoate 40 mg.

Clinico-pharmacological group: androgenic drug.

Mechanism of action Andriol is a drug testosterone, active ingestion. The active ingredient is testosterone undecanoate, ether natural testosterone. Testosterone in a pure form ingestion is inactive.

In contrast, testosterone undecanoate, due to its high fat soluble, and the availability of a special solvent - oleic acid, is absorbed with chylomicrons through the lymphatic system of the small intestine, enters the thoracic lymphatic duct and then through the superior vena cava immediately gets into the systemic circulation.

Thus, a sufficient amount of testosterone passes initial passage through the liver and inactivation in it, and in the systemic circulation rapidly achieved therapeutic concentrations of this hormone. In applying Andrioli in plasma level rises as testosterone and its active metabolite, which accounts for stable therapeutic effect. Andriol, unlike active after oral application of C-17-methylated derivatives of testosterone, has no effect on liver function.

Pharmacokinetics

Absorption

After ingestion of the small intestine absorbs 45-48% of the dose. Cmax in plasma obtained between 2.5 h and 5 h after a single dose.

Metabolism

Testosterone undecanoate is hydrolyzed with the formation of testosterone, the effect is similar to the effect of endogenous testosterone. Later formed active metabolites of testosterone: 5-alpha-dihydrotestosterone, androstenedione and estradiol, which by binding to corresponding receptors, cause a full spectrum of androgenic activity Andrioli. Putting T1 / 2 - 3-4 pm derive mainly from the urine as metabolites (two drugs and sulfates) in the first 24 hours - about 40%, and in one week - 50-70%.

A small amount of the active substance is excreted in the feces.

Statement

Hormone replacement therapy for disorders associated with testosterone deficiency:
postcastration syndrome syndrome;
evnuhoidizme;
hypopituitarism;
endocrine impotence;
climacteric disorders in males such as reduced libido and decrease in mental and physical activity.

In addition, testosterone can be shown with osteoporosis.

Dosage regimen

Typically, the dose should be set individually depending on the clinical effect. The recommended starting dose is 120-160 mg / day for 2-3 weeks. Maintenance dose - 40-120 mg / day. Andriol capsules should be taken after meals, washed down with a small amount of liquid swallowed whole without chewing. It is advisable to take half the dose in the morning and afternoon - evening. If the patient takes an odd number of capsules, the higher dose should be taken in the morning.

Side effect

On the part of the reproductive system: priapism, increased sexual arousal, premature puberty boys, increased frequency of erections, increase the size of the penis, oligospermia, reduced volume of ejaculate. From the water-electrolyte balance: sodium and water retention. Other: premature closure of growth zones of bones, dizziness, nausea.

Contraindications
verified or suspected carcinoma of the prostate or breast cancer.

Cautions

In the case of androgenozavisimyh side effects treatment should be discontinued. After their disappearance should resume treatment with lower doses.

Treatment of patients with latent or pronounced cardiac failure, impaired renal function, hypertension, epilepsy or migraine (or the notes on the history of these conditions) should be under constant surveillance, since androgens may occasionally induce sodium and water retention. Perhaps reducing belkovosvyazannogo iodine, but it has no clinical significance.

Use in Pediatrics

The boys in the prepubertal period, androgens should be used with caution to avoid premature closure of epiphyses and accelerated sexual development.

Overdose

Currently, cases of overdosing Andriol not reported.

Drug Interactions

Drug Interactions preparation Andriol is not described.

Terms and Conditions of storage

The drug should be stored in a dry place protected from light.

Shelf life at room temperature - 90 days. Shelf life at a constant temperature of 2 ° to 8 ° C - 3 years.