Composition, structure and packing

Cream 1% white or nearly white.

1 g of clotrimazole 10 mg.

Excipients: Vaseline medical, peach butter, polyethylene 400, emulsifier № 1, Methylparaben, nipazol, purified water.

Clinico-pharmacological group: Antifungal drug to external and local application.

Pharmacological action

Antifungal agent from the group of imidazole derivatives for topical and local application. Decreased synthesis of ergosterol, which is part of the microbial cell membrane wall, leads to a change in its structure and properties by causing lysis of cells.

At low concentrations fungistatic effect, but in large - fungicide, not only in proliferating cells. In fungicidal concentrations interacts with the mitochondrial enzymes and peroxidases, resulting in an increase in the concentration of hydrogen peroxide to toxic levels, which also contributes to the destruction of fungal cells.

It is active against pathogenic dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), yeast and fungi (the genus Candida, Torulopsis glabrata, genus Rhodotorula, Malassezia furfur), agents of a multi-colored lichen, erythrasma, Gram positive (Staphylococcus, Streptococcus, Corinobacterium minutissimum) and Gram-negative bacteria (Bacteroides, Gardnerella vaginalis), Trichomonas vaginalis.


The drug accumulates in the horny layer of the epidermis. Concentration in the deep layers of the epidermis is higher than the IPC for dermatophytes. Amiklon poorly absorbed through the skin and mucous membranes, almost no systemic action.

mycosis of the skin and mucous membranes (including ringworm, dermatophytosis, trichophytia, epidermofitiya, microsporia, kandidomikoz);
interdigital fungal erosion;
fungal paronychia;
candida balanitis;
pityriasis versicolor;
mycoses complicated by secondary pyoderma.

Dosage regimen

The drug is intended for external and local application. Cream Amiconi applied a thin layer to affected skin and mucous membranes 2-3 times / day, and gently rubbed. The dose for the size of a hand - a column of cream length of 5 mm.

The course of treatment an average of about 4 weeks. After a therapeutic effect appropriate to continue applying the drug for a further 14 days. The duration of therapy erythrasma - 2-4 weeks, with colored herpes - 1-3 weeks.

When fungal skin lesions feet after reaching the therapeutic effect it is recommended to continue treatment for 2-3 weeks. Before using the product of foot wash with warm soapy water, carefully wiped, especially between the toes. Side effects Allergic reactions: itching, urticaria.

Local reaction: a burning sensation, tingling at the site of application of cream, erythema, swelling, irritation, peeling.

I trimester of pregnancy;
Hypersensitivity to the drug's components.

Pregnancy and lactation

Amiklon drug is contraindicated in I trimester of pregnancy. The question of the advisability of the drug in phase II and III trimester of pregnancy should be decided individually.

Caution must be exercised when applying the drug during lactation.


Use in Pediatric Clinical data on efficacy and safety of the drug Amiklon children missing.


Data on drug overdose Amiklon not available.

Drug Interactions

With simultaneous use of amphotericin B, nystatin and natamycin with clotrimazole marked decline in the effectiveness of the latter.

Terms and Conditions of storage

The drug should be kept dry, away from children at or above 25 ° C.

Shelf life - 2 years.