2010/09/20

Amixin

Composition, structure and packing

Tablets, film-coated orange, round, biconvex, on the break - orange, allowed little blotches of orange or white.

1 tab. Tilorone (tilaksin) 1960 mg.

Excipients: potato starch, microcrystalline cellulose, povidone (kollidon 30), calcium stearate, croscarmellose sodium (primelloza).

The composition of the shell: gipromelloza (hydroxypropylmethylcellulose), titanium dioxide, macrogol 4000 (polyethylene glycol 4000), polysorbate 80 (Tween 80), quinoline yellow (E104), yellow-orange Seacove 85 (E110).

Tablets, film-coated orange, round, biconvex, on the break - orange, allowed little blotches of orange or white.

1 tab. Tilorone (tilaksin) 125 mg.

Excipients: potato starch, microcrystalline cellulose, povidone (kollidon 30), calcium stearate, croscarmellose sodium (primelloza).

The composition of the shell: gipromelloza (hydroxypropylmethylcellulose), titanium dioxide, macrogol 4000 (polyethylene glycol 4000), polysorbate 80 (Tween 80), quinoline yellow (E104), yellow-orange Seacove 85 (E110).

Clinico-pharmacological group: Antiviral and immunomodulatory drugs. Inductor synthesis of interferon.

Pharmacological action

Antivirus and immunomodulatory drugs. Low molecular weight synthetic inducer of interferon, stimulates the body's interferon alpha, beta, gamma. The main structures that produce interferon in response to the introduction Tiloron are cells of the intestinal epithelium, hepatocytes, T lymphocytes, neutrophils and granulocytes. After taking the drug inside a maximum production of interferon is defined in the sequence gut-liver-blood through the 4-24 hours Amixin has immunomodulating and antiviral effect. In human leukocytes induces the synthesis of interferon.

Stimulates bone marrow stem cells in a dose-dependent increases antibody production, reduces the degree of immunosuppression, restores the ratio of T-suppressors and T-helper cells. Effective with the various viral infections (including those caused by viruses, other pathogens of acute respiratory viral infections, hepatitis, herpes).

The mechanism of antiviral action is associated with inhibition of translation of virus-specific proteins in infected cells, resulting in suppressed reproduction of viruses.

Pharmacokinetics

Absorption

After taking the drug inside Tilorone rapidly absorbed from the gastrointestinal tract. Bioavailability is about 60%.

Distribution

Linking to plasma proteins - about 80%.

Metabolism and excretion

Tilorone not Biotransformation and not cumulative in the body. We derive a practically unchanged in the feces (70%) and urine (about 9%). T1 / 2 was 48 h.

Statement

Adults:
for the prevention and treatment of influenza and SARS;
for the treatment of viral hepatitis A, B and C;
for the treatment of herpes infection;
for the treatment of cytomegalovirus infection;
in the complex treatment of allergic encephalomyelitis and viral (including multiple sclerosis, leykoentsefality, uveoentsefality);
in the complex therapy of urogenital and respiratory chlamydia;
in the complex therapy of pulmonary tuberculosis.

In children older than 7 years:
for the treatment of influenza and SARS.

Dosage regimen

Drugs are taken by mouth after meals.

In adults, for nonspecific prevention of viral hepatitis A drug is administered in a dose of 125 mg 1 time per week for 6 weeks. Heading dose - 750 mg (6 pills)..

In the treatment of viral hepatitis A dose on the first day is 125 mg 2 times a day, then move on to receive 125 mg every 48 h. The course of treatment - 1.25 g (10 tab.).

In the treatment of acute hepatitis B in the initial phase of treatment in the first and second day of the dose is 125 mg / day and then 125 mg every 48 h. The course of treatment - 2 g (16 tab.).

With prolonged duration of hepatitis B in the first day dose is 125 mg 2 times / day, then 125 mg every 48 hours course dosage - 2.5 g (20 tab.).

In chronic hepatitis B in the initial phase of treatment the total dose of 2.5 g (20 tab.). In the first 2 days of daily dose of 250 mg, then move on to receive 125 mg every 48 hours

In the continuation phase of treatment the total dose ranging from 1.25 g (10 tab.) Up to 2.5 g (20 tab.), While the drug administered in a dose of 125 mg per week. Heading dose Amixin varies from 3.75 to 5 g, duration of treatment is 3.5-6 months, depending on the results of biochemical, immunological and morphological studies, reflecting the degree of activity of the process.

In acute hepatitis C in the first and second day of treatment Amixin prescribe a dose of 125 mg / day, then 125 mg every 48 hours course dosage - 2.5 g (20 tab.).

In chronic hepatitis C in the initial phase of treatment the total dose of 2.5 g (20 tab.). In the first 2 days of taking the drug at a dose of 250 mg / day, then 125 mg every 48 h. In the continuation phase of treatment the total dose of 2.5 g (20 tab.), With drug administered in a dose of 125 mg per week. Heading dose Amixin - 5 g (40 tab.), Duration of treatment is 6 months, depending on the results of biochemical, immunological and morphological studies, reflecting the degree of activity of the process.

When combined therapy neyrovirusnyh infections - at 125-250 mg / day in the first two days of treatment, then 125 mg every 48 hours dose set individually, duration of treatment is 3-4 weeks.

For treatment of influenza and other acute respiratory viral infection in the first 2 days of illness Amixin prescribe a dose of 125 mg / day, then 125 mg every 48 hours Coursework dose - 0.75 g (6 pi.).

To prevent influenza and SARS Amixin administered in a dose of 125 mg 1 time per week for 6 weeks. Heading dose - 750mg (6 pills)..

For the treatment of herpes, cytomegalovirus infection dose in the first 2 days of 125 mg, then take 125 mg in 48 hours Coursework dose is 1.25-2.5 g (10-20 pi.).

Urogenital and respiratory chlamydiosis Amixin prescribe a dose of 125 mg / day during the first 2 days, then 125 mg every 48 hours Coursework dose - 1.25 g (10 tab.).

When the complex treatment of pulmonary tuberculosis in the first 2 days of medication prescribed to 250 mg / day, then 125 mg every 48 hours course dosage - 2.5 g (20 tab.).

Children older than 7 years with uncomplicated forms of influenza or other acute respiratory viral medication is prescribed in doses of 60 mg (1 tab.) 1 times / day after meals for 1 st, 2 nd and 4 th day after treatment. Heading dose - 0.18 g (3 pi.).

With the development of complications of influenza and other acute respiratory viral drug taking 60 mg 1 time / day for 1 st, 2 nd, 4 th, 6 th day of starting treatment. Heading dose - 0.24 grams (4 tablets)..

Side effect

On the part of the digestive system: possible symptoms of dyspepsia. Other: possible intermittent fever, allergic reactions.

Contraindications
Pregnancy
breastfeeding;
Children under 7 years;
Hypersensitivity to the drug.

Pregnancy and lactation

Amixin contraindicated during pregnancy and during breastfeeding.

Cautions

Amixin compatible with antibiotics, and the means of the traditional treatment of viral and bacterial infections.

Overdose

So far, cases of overdose Amixin unknown.

Drug Interactions

Clinically significant drug interactions Amixin with antibiotics and the means of the traditional treatment of viral and bacterial infections have been detected.

Terms and Conditions of storage

List B. The drug should be stored out of reach of children, dry, dark place at temperatures not above 30 ° C. Shelf life - 3 years.