2010/09/20

Ambrosan

Composition, structure and packing

capsule with prolonged action,

intravenous fluids,

solution for oral administration

solution for oral use [of alcohol]

solution for oral and inhalation,

syrup

tablets

tablets with prolonged action,

Effervescent tablets

Pharmacological action

Mucolytic tool that stimulates the prenatal development of the lungs (increased synthesis, secretion of surfactant and block its decay). Has sekretomotornym, sekretoliticheskim and expectorant action; stimulates serous cells of glands of the mucous membrane of the bronchi, increases the content of mucous secretion and release of surface-active agent (surfactant) in the alveoli and bronchi; normalizes impaired ratio of serous and mucous components of sputum. By activating the hydrolyzing enzymes and increasing the release of lysosomes from the cells of Clarke, reduces the viscosity of sputum. Increases motor activity of ciliated epithelium, increases mucociliary transport. Once inside the action occurs within 30 min, with rectal administration - after 10-30 minutes and lasts for 6-12 hours with a parenteral effect occurs quickly and lasts for 6-10 hours

Statement
respiratory tract diseases with formation of viscous sputum:
Acute and chronic bronchitis,
pneumonia, COPD,
bronchial asthma with obstruction of sputum discharge,
bronchiectasis.
stimulation of prenatal lung maturation,
treatment and prevention (with threatened preterm labor and premature delivery shown induced between 28 and 34 weeks of pregnancy when the clinical picture suggests that the prolongation of pregnancy for 3 days), respiratory distress syndrome in premature infants and newborns.

Dosage regimen

Inside, during a meal, with a small amount of liquid.

Adults and children over 12 years, appointed - Tablets: 30 mg 3 times daily in the first 2-3 days, then 30 mg 2 times or 15 mg 3 times daily or 1 capsule retard (75 mg) in the morning, children 6-12 years - 15 mg 2-3 times a day.

Solution for oral administration (7.5 mg / ml) for adults during the first 2-3 days - 4 ml, and then 2 ml 3 times a day, or 4 ml 2 times a day for children under 2 years - 1 ml 2 times per day, 2-5 years - 1 ml 3 times daily, 5-12 years - 2 ml 2-3 times a day.

Syrup (3 mg / ml) for adults - in the first 2-3 days in 10 ml and then 5 ml 3 times per day or 10 ml 2 times a day.

In severe cases, the dose does not decrease during the entire course of treatment.

Children 5-12 years prescribe 15 mg 2-3 times daily, 2-5 years - 7.5 mg 3 times a day, up to 2 years - 7.5 mg 2 times a day.

In inhaled designate adults and children older than 5 years of 15-22.5 mg for children under 2 years - 7.5 mg, for children from 2-5 years - 15 mg 1-2 times a day.

In the case where there is no possibility to hold more than one inhalation per day, additionally used pills, oral solution or syrup.

Parenteral introduced in / m / v (slow jet or drip) or s / c: adults - 15 mg, in severe cases - 30 mg 2-3 times a day for children - 1.2-1.6 mg / kg 3 times day.

Usually children under 2 years - 7.5 mg 2 times a day, from 2 to 5 years - 7.5 mg 3 times daily, from 5 years - 15 mg 2-3 times a day.

For the treatment of respiratory distress syndrome in premature and newborn babies are introduced in / or / m - 10 mg / kg / day, the multiplicity of the introduction - 3-4 times, if necessary, the dose may be increased to 30 mg / kg / day.

For iv drip introducing 50 ml diluted in 500 ml infusion solution (as a solvent is used 0.9% solution of NaCl, 5% dextrose, Ringer-Locke or any other base solution with a pH no higher than 6.3), injected for 2 h at a speed of 84 drops / min. Re-treatment of the above scheme can be carried out in 14 days (while reading).

Parenteral administration is terminated after the disappearance of acute manifestations of the disease (moving to ingestion or rectal).

Rectal, adults and children over 12 years - 1 suppository (30 mg) 3 times a day for 2-3 days, then 60 mg 2 times a day, maximum daily dose - 0.12 g; children 6-12 years - 15 mg 2-3 times a day.

Not recommended for use without a doctor's appointment more than 4-5 days.

Side effect

Allergic reactions: skin rash, urticaria, angioedema, in some cases - allergic contact dermatitis, anaphylactic shock.

Rarely - weakness, headache, diarrhea, dry mouth and respiratory tract, exanthema, rhinorrhea, constipation, dysuria. With prolonged use at high doses - stomachalgia, nausea, vomiting. With the rapid i / v administration - a sense of numbness, weakness, intense headaches, lowering blood pressure, dyspnea, pyrexia, chills.

Contraindications
hypersensitivity
pregnancy (I term)
phenylketonuria (for medicines containing aspartame).

C carefully. Hepatic insufficiency.

Pregnancy and lactation

Use of the drug is contraindicated (I term).

Cautions

It should not be combined with antitussive drugs that prevent removal of sputum. Inhalation solution can be applied using any modern equipment for inhalation (except steam inhaler). Before inhalation of the drug is mixed with 0.9% solution of NaCl (for optimal humidification can be diluted in a ratio of 1:1) and heated to body temperature. Inhalation should be done in the usual mode of breathing (not to provoke cough shock).

Patients suffering from bronchial asthma, in order to avoid non-specific respiratory irritation and spasm before the inhalation of ambroxol is necessary to use bronchodilators.

Patients suffering from diabetes, you can designate as a syrup (5 ml syrup contains sorbitol and saccharin in an amount corresponding to 0.18 XU).

Children under 5 years of use suppositories 15 mg is not recommended to 12 years - 30 mg (for their use suppositories 15 mg).

Overdose

Symptoms: nausea, vomiting, diarrhea, dyspepsia.

Treatment: artificial vomiting, gastric lavage in the first 1-2 hours after taking the drug, receiving fat-containing products

Drug Interactions

The combined use of antitussive drugs leads to difficulty sputum discharge on the background to reduce coughing. Increase penetration in bronchial secretion of amoxicillin, cefuroxime, erythromycin and doxycycline. An injection can not be used with solutions having a pH above 6.3

Terms and Conditions of storage

Store in a dark place.