Composition, structure and packing

The tablets are white, flat, embossed "dp" on one side and scored - on the other.
1 tab. Paracetamol 325 mg;
phenylephrine hydrochloride 5 mg;
chlorphenamine maleate 2 mg.

Excipients: lactose monohydrate, polyvinylpyrrolidone, magnesium stearate, microcrystalline cellulose.

Clinico-pharmacological group: drugs used for colds.

Pharmacological action

Combination drug used for colds, the effect is due to the effects of its constituent components. Paracetamol has antipyretic, analgesic, and weak anti-inflammatory effect. Chlorphenamine, blocker of histamine H1-receptor, has anti-allergic effect.

Reduces the effects exudation, suppresses the symptoms of allergic rhinitis (nasal congestion, sneezing, rhinorrhea). Phenylephrine - sympathomimetic direct action. Influencing α-adrenergic receptors located in the arterioles of the mucous membrane nasal cavity, causes narrowing of arterioles than reduces swelling of mucous membranes and the number of discharge from the nasal cavity.


Data on the pharmacokinetics Anakold not available.

Rush for colds and other infectious and inflammatory diseases;
moderate or mild pain (including headache, myalgia, sore throat, dysmenorrhoea);
allergic conditions of the upper respiratory tract (nasal congestion, sneezing, rhinitis).

Dosage regimen

Adults appoint 2 tab. 3-4 times / day with an interval between doses of at least 4 hours daily dose should not exceed 12 tablets.

Children under the age of 12 appoint 1 tab. 4 times / day with an interval between doses of at least 4 hours daily dose - not more than 4 tabs. Duration of admission as a refrigerant - no more than 3 days, as analgesic - no more than 5 days.

The drug should be taken after meals.

Side effect
On the part of the digestive system: dyspepsia, abnormal liver function.
The part of the hemopoietic system: thrombocytopenia, leukopenia, agranulocytosis.
From the urinary system: urinary retention, renal failure.

Allergic reactions: skin rash, itching, hives.

Other: tachycardia, lethargy, listlessness.

genetic absence of glucose-6-phosphate dehydrogenase;
blood diseases;
expressed by the dysfunction of the liver or kidneys;
Gilbert's syndrome (Constitutional hyperbilirubinemia);
Children under 12 years
Hypersensitivity to the drug's components.

Pregnancy and lactation

Anakold drug is contraindicated during pregnancy and lactation (breastfeeding).

Application for violations of liver function

Contraindications disturbancies liver function.

Precautions should use the drug in patients with impaired liver function.

Application for violations of renal function

Contraindications disturbancies function pochek.S caution should be used drug in patients with impaired renal function.


Precautions should use the drug in patients with impaired liver function and kidney failure, chronic heart disease, hyperthyroidism, and elderly patients. To prevent toxic liver damage drug should not be combined with alcohol intake, and take those prone to chronic alcoholism.


Symptoms: nausea, vomiting, stomach pain, and in severe cases - psychomotor agitation, dizziness, loss of appetite, kidney failure, encephalopathy and coma.

Treatment: the victim should do a gastric lavage, appoint adsorbents (activated carbon) and a symptomatic therapy.

Drug Interactions

With simultaneous use of the drug Anakold with barbiturates, phenytoin, carbamazepine, rifampicin, zidovudine and other inducers of microsomal liver enzymes increased risk of hepatotoxic action.

The simultaneous use Anakolda with indirect anticoagulants (including warfarin) increases the risk of bleeding. When applied simultaneously with drugs depressing the central nervous system (barbiturates, ethanol, opioid analgesics), increasing sedation Anakolda.

With simultaneous application Anakold increases the effect of MAO inhibitors. With simultaneous application Anakolda with drugs having anticholinergic activity (atropine, some antidepressants), increased anticholinergic effects.

Combined use of tricyclic antidepressants can lead to a sharp increase in blood pressure. The simultaneous use of glucocorticoids increases the risk of developing glaucoma.

Terms and Conditions of storage

The drug should be stored out of reach of children, dry, dark place at temperatures not above 30 ° C. Shelf life - 3 years.