Composition, structure and packing

Coated tablets green, biconvex shape on the break - the core of yellow, limited to the edges of the white and green shell.

1 Pill

digidroergokristina mesilate 580 mg,

including digidroergokristin 500 mcg.

esculin trihydrate 1.62 mg,

including esculin 1.5 mg.

rutozida trihydrate 32.66 mg,

including rutozid 30 mg.

Excipients: lactose, corn starch, stearic acid, stearin, povidone, sodium karboksimetilkrahmal, sucrose, talc, polyvinyl acetate, sodium karmelloza, white wax, carnauba wax, titanium dioxide (E171), patent blue dye (E131), quinoline dye ( E104).

Clinico-pharmacological group: venotonic drug.

Pharmacological action

Combined preparation has antihydropic, venotonic, arteriodilatiruyuschee action. Digidroergokristin extends arterioles (alpha-adrenoceptor blocking), increases venous tone (a direct effect on smooth muscle). Esculin and rutozid reduce the increased permeability and fragility of the capillaries; promote regression of disorders of venous circulation and microcirculation. Esculin also provides antiexudative action.

varicose veins
predvarikozny syndrome
chronic venous insufficiency (including on the background of postthrombotic syndrome);
trophic ulcers of the lower leg
trauma-induced microcirculatory disorders (long immobilizaniya).

Dosage regimen

Inside, after a meal. Initial dose - 2 tablets 3 times daily for 1 week or 20 cap 4 times a day, maintenance dose - 1 tablet or 20 cap 3 times a day.

Side effect

Rarely - allergic reactions (hives, skin rash, itching), swelling of the nasal mucosa, headache, dizziness, fatigue, nausea, vomiting, diarrhea, metrorrhagia, menorrhagia.

children's age (15 years),
pregnancy (I term)

C carefully. Severe liver dysfunction and / or kidneys, decompensated CHF, bradycardia, hypotension, pregnancy (II-III trimesters).

Pregnancy and lactation

Use drug with caution, especially II-III trimesters.


During the period of treatment must be careful when driving and other lesson potentially dangerous activities which require high concentration and speed of psychomotor reactions.

Drug Interactions

Oleandomycin, erythromycin, doxycycline, tetracycline, dopamine, vasodilators, alpha-blockers, beta-adrenostimulyatorov can strengthen, and alpha-adrenostimulyatorov, vasopressin and other vasoconstrictors to reduce the effectiveness of Anavenola.

Terms and Conditions of storage

Store in a dry place protected from light.