Composition, structure and packing

Coated tablets white, round, with a fault line on one side and engraved "CTZ 10" - on the other.

1 tab. cetirizine hydrochloride 10 mg.

Excipients: lactose monohydrate, starch, magnesium stearate, gipromelloza, titanium dioxide, macrogol.

Clinico-pharmacological group: blocker histamine H1-receptors.

Antiallergic drug.

Pharmacological action

Blocker histamine H1-receptors. Possesses strong anti-allergic effect. No sedation in pharmacologically active doses. Cetirizine belongs to the selective blockers of histamine H1-receptors and almost no anticholinergic and antiserotoninovogo action.

The drug prevents the development and facilitates during allergic reactions, has antipruritic and antiexudative action. Influences on the early stage of allergic reactions, and also reduces the migration of inflammatory cells, inhibits the release of mediators involved in late allergic reaction.

Decreases capillary permeability, prevents the development of edema, relieves spasm of smooth muscles. Eliminates skin reaction to the introduction of histamine, specific allergens, as well as on cooling (in cold urticaria). Cetirizine significantly reduces hyperreactivity bronchial tree, occurring in response to the release of histamine in patients with bronchial asthma. Against the background of course of treatment tolerance does not develop. The therapeutic effect is on average 60 min after ingestion.


Absorption and distribution

Once inside the time to reach Cmax in the plasma - 1 pm Do not cross the BBB, penetrates into the breast milk.


In small quantities, is metabolized in the liver (in contrast to other blockers of histamine H1-receptors, which are metabolized in the liver, with the participation of cytochrome).


T1 / 2 in adults is 7-10 h in children aged 6 to 12 years - 6 pm

Pharmacokinetics in special clinical situations

Patients who are on hemodialysis, T1 / 2 is prolonged to 20 hours


Symptomatic treatment:
seasonal and chronic allergic rhinitis;
allergic conjunctivitis;
chronic idiopathic urticaria;
Quincke's edema;
other allergic dermatitis, accompanied by itching and rash.

Dosage regimen

Inside adults and children over the age of 12 years, 10 mg (1 tab.) 1 times / day every day.

Children aged 6 to 12 years - 5 mg (1 / 2 tab.) 2 times / day or 10 mg (1 tab.) 1 times / day. Patients with renal failure dose should be reduced in 2 times.

Side effect

Analergin drug is generally well tolerated, and adverse reactions are minor and reversible.

From the side of the central nervous system: possible headache, dizziness, drowsiness.

On the part of the digestive system: dry mouth, gastrointestinal disorders (including pain in the epigastrium, nausea, diarrhea). Allergic reactions: seldom - angioedema, rash, hives, itchy skin.

terminal stage chronic renal failure (including patients on dialysis);
Children under 6 years
lactation (breastfeeding);
Hypersensitivity to the drug's components.

Pregnancy and lactation

Analergin contraindicated in pregnancy and lactation. Application for violations of renal patients with renal failure dose should be reduced in 2 times.


In the period of treatment to avoid the abuse of alcohol, although in therapeutic doses of cetirizine not potentiates the action of ethanol at a joint reception.

Precautions should be prescribed medication in elderly patients. The patient should not take the drug for a long time (more than 7 days) without a physician's recommendation.

Effects on ability to drive vehicles and management mechanisms

When driving a car or other technical means of control should not exceed the recommended dose.


Symptoms: dryness of the company, drowsiness, lethargy, weakness, headache, tachycardia, urinary retention, constipation, anxiety, irritability.

Treatment: while taking the drug in doses exceeding the recommended 5 times, should be a gastric lavage. Shown holding a symptomatic therapy. The specific antidote is not known. Hemodialysis is not effective.

Drug Interactions

So far, no information about possible interactions of cetirizine with other drugs.

Terms and Conditions of storage

The drug should be stored protected from light and away from children at a temperature of 10 ° to 25 ° C. Shelf life - 2 years.