2010/09/21

Artrodarin

Hard gelatin capsules, the size № 1, consisting of white opaque body and green opaque lids, the contents of capsules - granules are yellow and odorless.

1 capsule. diatserein 50 mg

Excipients: lactose monohydrate, croscarmellose sodium, povidone K30, colloidal silicon dioxide, magnesium stearate, indigotine (E132), iron oxide yellow (E172), titanium oxide (E171), gelatin.

Clinico-pharmacological group

The drug used in inflammatory and inflammatory-dystrophic diseases of the locomotor system.

Pharmacological action

Anti-inflammatory drug, an inhibitor of the synthesis and activity of interleukin-1 (IL-1). IL-1 plays an important role in the development of inflammation, degradation and the subsequent destruction of cartilage in osteoarthrosis.

In addition, diatserein inhibits the action of other cytokines that cause inflammation, including IL-6, TNF. Diatserein also slows down the formation of metalloproteases (collagenase, elastase), which are involved in the process of damaged cartilage. With prolonged use diatserein stimulates the synthesis of proteoglycans and does not affect the synthesis of prostaglandins.

Pharmacokinetics

Absorption and metabolism

After taking the drug inside diatserein rapidly absorbed from the gastrointestinal tract and fully deatsetiliruetsya to Reina. Acceptance of the drug simultaneously with food increases bioavailability by 25%. Reina Cmax in plasma is achieved through 144 min. In single dose of the drug in a dose of 50 mg Cmax reached 3.15 mg / liter. Repeatedly taking the drug Cmax Reina increases in relation to cumulation.

Distribution and excretion

Linking Reina albumin reaches almost 100%. Reina penetrates through the BBB and placental barrier. T1 / 2 is 255 min. Reina derived kidneys unchanged (20%) and glucuronide (60%) and sulfate (20%).

Indications for use of the drug
primary and secondary osteoarthritis.

Dosage regimen

The drug is usually prescribed 1 capsule 2 (morning and evening after meals).

The capsules should be swallowed whole without chewing, and wash down with water.

Effect of treatment should be expected in 2-4 weeks. Artrodarin designed for continuous long-term use or for the exchange rate of the duration of the course at least four months.

Side effect

If you are sensitive to the components of the drug possible allergic reactions of varying severity.

On the part of the digestive system: the initial period of therapy may include diarrhea, nausea, vomiting, abdominal pain. In this case the dose can be reduced to 1 capsule.

During the administration of the drug may be an intense staining of urine from yellow to brown (depending on pH), which does not require dose reduction (cancellation) of the drug.

Contraindications to the use of the drug
Pregnancy
lactation (breastfeeding);
childhood and adolescence (18 years);
individual intolerance to the components of the drug or hypersensitivity to antrahionovym drugs (such as a laxative).

Precautions designate patients with irritation of the lower intestine, chronic renal insufficiency.

Pregnancy and lactation

The drug is contraindicated during pregnancy and lactation.

Application for violations of liver function

With caution is prescribed for chronic renal failure. With the deterioration of renal function the physician should reduce the dose of the drug.

Cautions

The duration of therapy depending on the result achieved can be lengthy.

To achieve the therapeutic effect Artrodarin ® should be administered in conjunction with analgesics and NSAIDs.

Against the background of the drug requires periodic monitoring of the pattern of peripheral blood and liver enzymes.

With the deterioration of renal function the physician should reduce the dose of the drug.

Overdose

Symptoms: diarrhea, weakness.

Treatment: symptomatic. Patients should be warned about the need to see a doctor in case of overdose.

Drug Interactions

Artrodarin should not be taken concurrently with substances that affect the quality of the intestinal contents and its rate of discharge (including a lot of fiber).

Antacids reduce the absorption of the drug.

With the simultaneous use of antibiotics or chemotherapy drugs that affect the intestinal microflora may increase the frequency of adverse reactions from the intestine.

To the top

Drug prescription.

Terms and Conditions of storage

The drug should be stored protected from light and away from children at or above 25 ° C. Shelf life - 3 years.