Composition, structure and packing

Capsules of two species. Capsules green 1 capsule. acetylsalicylic acid 250 mg ascorbic acid 300 mg Rutin 20 mg.

Excipients: sugar, potato starch, talc, calcium stearate.

Capsules white 1 capsule. metamizole 250 mg of diphenhydramine 20 mg of calcium gluconate 100 mg Excipients: sugar, potato starch, talc, calcium stearate. 10 pcs. - Packaging of cellular outline (1) in a combination packaging.

Composite packaging contains a blister with capsules of green color and a blister with capsules of a white carton box.

Clinico-pharmacological group: Analgesic-antipyretic combination composition.

Pharmacological action

Combination drug has analgesic, antipyretic, anti-inflammatory, anti-allergic and angioprotective action. Acetylsalicylic acid has analgesic, antipyretic and anti-inflammatory effects, inhibits platelet aggregation. Ascorbic acid (vitamin C) plays an important role in the regulation of redox processes, carbohydrate metabolism, blood coagulation, tissue regeneration, enhances the body's resistance. Rutin normalizes and supports the structure, flexibility, function and vascular permeability, and also has antioxidant, anti-inflammatory and anti-allergic effect.

Metamizole possesses analgesic, antipyretic and weak anti-inflammatory effects, the mechanism of which is associated with inhibition of prostaglandin synthesis. Diphenhydramine has antiallergic, anti-action. Reduces vascular permeability, eliminates swelling and hyperemia of the nasal mucosa, reduces back of the throat and allergic reactions of the upper respiratory tract. Calcium gluconate is a regulator of the exchange of calcium and phosphorus, reduces vascular permeability.

In allergic diseases or conditions it is recommended that a joint application with antihistamines.


Data on the pharmacokinetics Antigrippin-Envy is not available.

symptomatic treatment of influenza, SARS, colds in adults and adolescents over 15 years.

Dosage regimen

The drug is prescribed to adults and adolescents over 15 years: 2 capsules to receive: 1 green and 1 white capsule capsule. The duration of admission was 3-5 days before the disappearance of symptoms. Capsules are taken by mouth 2-3 times per day after meals, washed down with water. Patients should be warned that in the absence of better feeling taking the drug should be discontinued and a doctor.

Side effect

On the part of the digestive system: anorexia, nausea, vomiting, stomachalgia, diarrhea, erosive and ulcerative lesions GIT, gastrointestinal bleeding, liver failure.

Since the cardiovascular system: raising blood pressure, tachycardia. Allergic reactions: skin rash, Quincke's edema, bronchospasm (with the propensity to bronchospasm may provoke an attack).

Side effects found at the long-term use (more than 7 days).

The part of the hemopoietic system: thrombocytopenia, agranulocytosis, leukopenia.

From the side of the central nervous system: dizziness, headache, blurred vision, tinnitus, deafness.

From the blood coagulation system: reduction of platelet aggregation, hypocoagulation, hemorrhagic syndrome (including nosebleeds, bleeding gums, purpura). Allergic reactions: anaphylactic shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).

From the urinary system: kidney with papillary necrosis, renal dysfunction, oliguria, anuria, proteinuria, interstitial nephritis, stained urine red due to excretion of metabolites.

Other: teenagers - Reye syndrome (hyperpyrexia, metabolic acidosis, disorders of the nervous system and psyche, vomiting, abnormal liver function).

Patients should be warned that all the side effects, including those not listed above, you should inform your doctor and stop taking the drug.

bleeding tendency;
inhibition of blood (agranulocytosis, neutropenia, leukopenia);
hemorrhagic diathesis (haemophilia, von Willebrand disease, telangiectasia, gipoprotrombinemii, thrombocytopenia, thrombocytopenic purpura);
vitamin K;
bronchial asthma and illnesses with bronchospasm;
severe liver problems;
portal hypertension;
severe renal dysfunction;
deficiency of glucose-6-phosphate dehydrogenase (including with hereditary hemolytic anemia caused by deficiency of the enzyme);
dissecting aneurysm of the aorta;
hypercalcemia (calcium ion concentration should not exceed 12 mg% or 6 mEq / l);
nephrolithiasis (calcium);
glycoside intoxication (risk of arrhythmias);
lactation (breastfeeding);
childhood and adolescence to 15 years;
Hypersensitivity to the drug's components.

Pregnancy and lactation

The drug is contraindicated in pregnancy. If necessary, the appointment during lactation should stop breastfeeding for a period of preparation. Acetylsalicylic acid has teratogenic effect: when used in the I trimester of pregnancy leads to the splitting of the upper sky, in the III trimester - to a premature closure of ductus arteriosus in the fetus, which causes pulmonary vascular hyperplasia and hypertension in the vessels of pulmonary circulation, and to the inhibition of labor ( due to inhibition of prostaglandin synthesis). Acetylsalicylic acid is excreted in breast milk, which increases the risk of bleeding in a child due to dysfunction of platelets.

Application for violations of liver function

Contraindicated in severe liver problems, and in portal hypertension.

Application for violations of renal function

Contraindicated in severe renal dysfunction.


With care prescribers with hyperuricemia, urate nephrolithiasis, gout, gastric ulcer and duodenal ulcer (in history), decompensated heart failure.

Prolonged use of the drug is necessary to monitor patterns of peripheral blood and laboratory parameters of the functional state of the liver. Since acetylsalicylic acid has antiaggregant action, the patient, if he is to surgery, should be forewarned about the doctor taking the drug. Acetylsalicylic acid in low doses reduces the excretion of uric acid, which may in some cases to provoke an attack of gout.

Appointment of ascorbic acid to patients with rapidly proliferating and rapidly metastasizing tumors may increase during the process. In patients with bronchial asthma and hay while taking the drug may develop hypersensitivity reactions. In connection with the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones necessary to monitor renal function and blood pressure. Do not appoint a drug with anticoagulants, SCS, ticlopidine, urikozuricheskimi and antihypertensive therapy.

Ascorbic acid may distort the results of various laboratory tests (determination of glucose, bilirubin and activity of hepatic transaminases, LDH in the blood plasma). Radiopaque substances, colloidal blood substitutes and penicillin should not be used during the application Metamizole. Against the background of the drug should avoid alcohol because of the increased risk of gastrointestinal bleeding.

Use in Pediatrics

The drug is not prescribed as a febrifuge for children under 15 years of age with acute respiratory viral diseases because of the risk of developing Reye syndrome (encephalopathy and acute fatty liver with development of acute liver failure).

Effects on ability to drive vehicles and management mechanisms

During the period of the drug should refrain from classes of potentially hazardous activities that require attention and quickness of psychomotor reactions.


Symptoms: nausea, vomiting, stomach pain, sweating, pale skin, tachycardia, with slight overdose - ringing in the ears when expressed overdose - drowsiness, collapse, convulsions, bronchospasm, shortness of breath, anuria, bleeding, progressive respiratory paralysis, respiratory acidosis.

Treatment: artificial vomiting, gastric lavage, the appointment of saline laxatives, activated carbon, with the appearance of convulsions - in / to the introduction of diazepam and barbiturates, if necessary - the holding of forced diuresis, hemodialysis.

Drug Interactions

With simultaneous application Antigrippin-Envy increases the effects of heparin, indirect anticoagulants, reserpine, steroid hormones and hypoglycemic funds.

With simultaneous application Antigrippin-Envy reduces the effectiveness of spironolactone, furosemide, antihypertensives and urikozuricheskih funds. Antigrippin-Envy increases the side effects of GCS, sulfonylurea derivatives, methotrexate, non-narcotic analgesics and NSAIDs.

With simultaneous application Antigrippin-Envy with barbiturates, antiepileptic drugs, zidovudine, rifampicin and etanolsoderzhaschimi drugs increases the risk of hepatotoxic action. Ascorbic acid enhances the absorption in the intestine of iron preparations. Tricyclic antidepressants, oral contraceptives and allopurinol metabolism violate Metamizole in the liver and increase its toxicity. The simultaneous use of Metamizole with cyclosporine reduces the level of the latter in the blood plasma. Sedatives and tranquilizers increase the analgesic effect Metamizole.

At simultaneous application with Metamizole tiamazol melphalan and increase the risk of leucopenia.

Terms and Conditions of storage

The drug should be stored in dry, light, reach of children at room temperature. Shelf life - 2 years.