1 tab.

Paracetamol 325 mg.

phenylephrine hydrochloride 5 mg.

chlorphenamine maleate 2 mg.

Powder for solution for oral

A pack.

Paracetamol 650 mg.

phenylephrine hydrochloride 10 mg.

chlorphenamine maleate 4 mg.

Excipients: ascorbic acid, citric acid, natural lemon flavor, pregelatinized starch, silicon dioxide, sodium citrate, sucrose, titanium dioxide, calcium phosphate tribasic, pigments (aluminum paints yellow № 6 and № 10).

Clinico-pharmacological group: agents for symptomatic treatment of acute respiratory diseases

Pharmacological action

Combined tool whose action caused by its constituent components; has antipyretic, alpha-adrenostimuliruyuschee, vasoconstriction demonstrated and antihistamine effect, eliminates the symptoms of "colds". Paracetamol blocks COX predominantly in the central nervous system by acting on pain centers and thermoregulation, which explains the almost complete absence of anti-inflammatory effect. Lack of effect of paracetamol on the synthesis of Pg in the peripheral tissues determines that it has no negative effect on water-salt metabolism (sodium and water retention), and gastrointestinal mucosa. Phenylephrine - sympathomimetic, narrows blood vessels, eliminates swelling and hyperemia of nasal mucosa, nasopharynx and paranasal sinuses, reduces exudative manifestations. Chlorphenamine - blocker of histamine H1-receptors suppresses the symptoms of allergic rhinitis: sneezing, rinoreyu, itchy eyes, nose, throat. Onset of action - 20-30 min, duration - 4-4.5 hours

febrile syndrome ("colds" and infectious diseases);

Dosage regimen

Ext. Adults - 2 tablets at intervals of 4 hours

The maximum daily dose - 12 tablets.

Children over 6 years - 1 tablet with an interval of 4 h, the maximum daily dose - 5 tablets for no more than 7 days.

Or, adults and children over 12 years - 1 sachet every 4 h, but not more than 4 bags a day.

Before taking the contents of 1 sachet dissolved in a glass of hot water.

Course - 3 days (no more).

Side effect

Allergic reactions (skin rash, itching, urticaria, Quincke's edema), nausea, epigastric pain, anemia, thrombocytopenia, agranulocytosis. Increased irritability, dizziness, increased blood pressure, the violation of sleep. Mydriasis, paresis of accommodation, increased intraocular pressure, dry mouth, urinary retention. With prolonged use at high doses - Hepatotoxic effects, hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia, nephrotoxicity (renal colic, pyukozuriya, interstitial nephritis, papillary necrosis).

lactation, infancy (up to 6 years).

With care - lack of glucose-6-phosphate dehydrogenase; diseases of the blood, liver and / or renal failure, angle-closure glaucoma, prostatic hyperplasia, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor), arterial hypertension, thyroid disease, diabetes, emphysema, chronic bronchitis.

Pregnancy and lactation

Acceptance of the drug is contraindicated.


In hyperthermia, continuing more than 3 days, and pain syndrome - more than 5 days, you want to consult a doctor. The risk of liver damage increases in patients with alcoholic hepatosis. Distorts the performance of laboratory research in the quantitative determination of glucose and uric acid in plasma. In the case of long-term care spend control of peripheral blood and functional state of the liver. During the period of treatment should refrain from driving motor vehicles and classes of potentially hazardous activities that require high concentration and speed of psychomotor reactions


Symptoms (due to paracetamol occur after receiving more than 10-15 g): pale skin, loss of appetite, nausea, vomiting; gepatonekroz; increase in activity of "liver" enzymes, increased prothrombin time.

Treatment: gastric lavage in the first 6 h, the introduction of donators of SH-groups and the precursors of glutathione synthesis - through methionine 8-9 h after the overdose and N-acetylcysteine within 12 hours

Drug Interactions

Enhances the effects of MAO inhibitors, sedatives, ethanol. Ethanol enhances the sedative effect of antihistamines. Antidepressants, phenothiazine derivatives, antiparkinsonian and antipsychotic funds increase the risk of urinary retention, dry mouth, constipation. GCS increase the risk of developing glaucoma. Paracetamol reduces the effectiveness urikozuricheskih drugs. Chlorphenamine concurrently with MAO inhibitors, furazolidone can lead to hypertensive crises, excitation, hyperpyrexia. Tricyclic antidepressants increase the sympathomimetic effect, co-administration of halothane increases the risk of ventricular arrhythmias. Decreases hypotensive effect guanetidina, which in turn reinforces the alpha activity adrenostimuliruyuschuyu phenylephrine.

Terms and Conditions of storage

In dry, the reach of children, at a temperature of 15-30 ° C.