Composition, structure and packing

Capsules of two species. Hard gelatin capsules II, blue, the contents of capsules - a mixture of powder and / or granules of white or white with kremovatym or pinkish tint, granules of irregular shape, different size, are allowed lumps.

1 capsule. Paracetamol 360 mg.

Excipients: Starch gelled, lactose, magnesium stearate, colloidal silicon dioxide. The composition of the shell capsules: gelatin, water, sodium lauryl sulfate, methylparaben, propylparaben, dyes (blue V, karmoizin, titanium dioxide).

Hard gelatin capsules R, red, size number 0; content capsules - mix powder and / or granules of yellow to greenish or white, irregularly shaped granules of different size, are allowed lumps.

1 capsule. rimantadine 50 mg Loratadine 3 mg ascorbic acid 300 mg rutozid 20 mg of calcium gluconate 100 mg.

Excipients: potato starch, magnesium stearate. The composition of the shell capsules: gelatin, water, sodium lauryl sulfate, methylparaben, propylparaben, dyes (Ponceau 4R, blue V, titanium dioxide).

Powder for solution for oral administration as a mixture of grains of almost white powder with a greenish-yellow, with a characteristic odor; prepared solution is colorless or yellowish color, slightly cloudy, with a characteristic odor (lemon, lemon with honey, raspberry, black currant ) allowed the presence of undissolved particles are yellow.

A pack. Paracetamol 360 mg of rimantadine hydrochloride 50 mg Loratadine 3 mg ascorbic acid 300 mg rutozid 20 mg calcium gluconate monohydrate 100 mg.

Excipients: aspartame, gipromelloza, colloidal silicon dioxide, lactose, food flavoring (lemon, lemon with honey, raspberry, blackcurrant).

Clinico-pharmacological group: Preparation for etiotropic and symptomatic treatment of respiratory viral infections.

Pharmacological action

Combined with the antiviral drug, interferonogenic, antipyretic, anti-inflammatory, analgesic, anti-allergic and angioprotective action. Paracetamol has antipyretic, analgesic and anti-inflammatory action. Ascorbic acid participates in the regulation of redox processes, carbohydrate metabolism, and normalizes capillary permeability, blood coagulation, tissue regeneration, activates the immune system.

Calcium gluconate prevents the development of increased permeability and fragility of vessels, which cause hemorrhagic processes in influenza and SARS, and restores the capillary blood circulation and has anti-allergic action (mechanism unclear). It is recommended to use in combination with antihistamines to treat allergic reactions.

Rimantadine - antiviral agent, active against influenza virus type A (especially A2). Reduces toxic manifestations caused by viruses and other types of viruses that cause a variety of SARS. It has also interferonogenic properties, increases the total content of interferon in the blood (especially interferon gamma). Enhances the efficacy of viral respiratory tract infections.

Rutozid - angioprotectors. By eliminating the increased permeability of capillaries, reducing its swelling and inflammation, strengthens the vascular wall. It has antiplatelet activity and increases the degree of deformation of erythrocytes.

Loratadine - blocker of histamine H1-receptor, has anti-allergic effect, prevents the development of edema associated with histamine release.


Data on the pharmacokinetics Antigrippin-Max is not available.


Etiotropic and symptomatic treatment of adults and children older than 12 years:
the flu;
with ARI;
with pyrexia due to viral respiratory disease.

Dosage regimen

Adults and children over 12 years, the drug should be taken by mouth after a meal; capsules should be washed down with water. Antigrippin-Max capsules use 1 capsule n blue and 1 red capsule F 2-3 times / day until disappearance of symptoms. Antigrippin-Max in the form of powder for solution for oral use 1 sachet 2-3 times / day until disappearance of symptoms.

Preparation of solution: the contents of 1 sachet dissolved in 1 cup boiling hot water. Drink hot, pre-mix.

The duration of treatment is 3-5 days (not more than 5 days). If within 3 days after the start of the drug to improve well-being is not observed, taking the drug should be discontinued and a doctor.

Side effect

From the side of the central nervous system: rarely - increased irritability, tremor, hyperkinesia.

On the part of the digestive system: possible (with a duration of more than 7 days) - damage to the mucous membrane of the stomach and duodenal ulcers, dyspepsia, dry mouth, anorexia, flatulence, diarrhea.

On the part of the hemopoietic system: possible (with a duration of more than 7 days) - agranulocytosis, leukopenia, thrombocytopenia, neutropenia, anemia. Allergic reactions: seldom - skin rash, itching, hives. In the case of onset of symptoms of side effects should immediately stop taking the drug and consult a doctor.

erosive and ulcerative lesions in the gastrointestinal tract exacerbation;
gastrointestinal bleeding;
bleeding diathesis;
portal hypertension;
vitamin K;
acute and worsening of chronic kidney disease (including acute glomerulonephritis, acute pyelonephritis);
renal failure;
or acute exacerbation of chronic liver disease (including acute hepatitis);
Lactation (breastfeeding);
Hypersensitivity to the drug's components.

With careful use the drug for epilepsy and cerebral arteriosclerosis.

Pregnancy and lactation

The drug is contraindicated during pregnancy and lactation (breastfeeding).

Application for violations of liver function

Contraindicated in acute or exacerbation of chronic liver diseases (including acute hepatitis) and portal hypertension.

Application for violations of renal function

Contraindicated in acute and worsening of chronic kidney disease (including acute glomerulonephritis) and renal insufficiency.


Long-term use - no more than 5 days. With prolonged use (more than 7 days) may be exacerbation of chronic comorbidities, elderly patients with hypertension increases the risk of hemorrhagic stroke (due to the incoming of the drug rimantadine hydrochloride).

The drug should not be applied in the presence of metastatic tumors. Use in pediatric drug should not be used in children under the age of 12 years.


Symptoms: in the first 24 h may be pallor, nausea, vomiting, pain in the epigastric region, tremor, drowsiness, tachycardia, increased levels of bilirubin in the blood, metabolism, exacerbation of associated chronic diseases.

Treatment: must call artificial vomiting, wash out the stomach, to appoint adsorbents, a symptomatic therapy. If overdose should consult a doctor.

Drug Interactions

If necessary, the simultaneous application of Antigrippin-Maximum use of other drugs should consult with your doctor. Avoid the simultaneous application of Antigrippin-Maximum with anticoagulants, SCS, hepatotoxic means, barbiturates, anticonvulsant, rifampicin, alcohol (ethanol).

With the simultaneous use of metoclopramide may increase absorption of active substances of the drug.

At simultaneous application with indirect anticoagulants of coumarin derivatives may develop a small gipoprotrombinemii.

Terms and Conditions of storage

The drug should be stored out of reach of children, dry, dark place at temperatures not above 25 ° C. Shelf life - 2 years.