2010/09/21

Arbidol

Composition, structure and packing

Capsule yellow capsule content - a mixture containing granules and powder from white to white with a greenish-yellow or kremovatym color.

1 capsule. metilfeniltiometil-dimetilaminometil gidroksibromindol-carboxylic acid ethyl ester 50 mg.

Excipients: potato starch, microcrystalline cellulose, colloidal silicon dioxide (aerosil), krospovidon (kollidon 25), calcium stearate.

Composition of hard gelatin capsules: titanium dioxide (E171), quinoline yellow (E104), sunset yellow dye, metilgidroksibenzoat, propilgidroksibenzoat, acetic acid, gelatin and titanium dioxide (E171), quinoline yellow (E104), sunset yellow (E110), gelatin .

Capsules with a white body and yellow cap, the contents of capsules - a mixture containing granules and powder from white to white with a greenish-yellow or kremovatym color.

1 capsule. metilfeniltiometil-dimetilaminometil gidroksibromindol-carboxylic acid ethyl ester 100 mg.

Excipients: potato starch, microcrystalline cellulose, colloidal silicon dioxide (aerosil), krospovidon (kollidon 25), calcium stearate.

Composition of hard gelatin capsules: titanium dioxide (E171), quinoline yellow (E104), sunset yellow dye, metilgidroksibenzoat, propilgidroksibenzoat, acetic acid, gelatin and titanium dioxide (E171), quinoline yellow (E104), sunset yellow (E110), gelatin .

Clinico-pharmacological group: Antiviral and immunomodulatory drugs.

Inductor synthesis of interferon.

Pharmacological action

Antiviral drug, has immunomodulating and influenza action, specifically inhibits the influenza viruses A and B, severe acute respiratory syndrome (SARS).

Barriers to contact and penetration of viruses into cells by inhibiting fusion of the lipid membrane of the virus with cell membranes. It has interferon-inducing action, stimulates humoral and cellular immune response, phagocytic function of macrophages, increases resistance to viral infections.

Reduces the incidence of complications associated with viral infection, as well as exacerbations of chronic bacterial diseases. Therapeutic efficacy in viral infections seen in reduced severity of intoxication and the clinical phenomena, reducing the duration of the illness. It belongs to low-toxic drug (LD50> 4 g / kg). Does not have any negative impact on the human body after oral application in the recommended doses.

Pharmacokinetics

Absorption and distribution

After ingestion is rapidly absorbed from the gastrointestinal tract. C max when receiving doses of 50 mg achieved through 1.2 h, C max when receiving doses of 100 mg - 1.5 hours Arbidol rapidly distributed to organs and tissues of the body.

Metabolism and excretion

Metabolised in liver. T1 / 2 of 17-21 h. About 40% is excreted unchanged in, mainly with the bile (38.9%) and in small quantities - by the kidneys (12%). During the first day shows 90% of applied dose.

Statement

The drug used in adults and children for the prevention and treatment:
influenza A and B, SARS, severe acute respiratory syndrome (SARS), including complicated by bronchitis and pneumonia;
secondary immunodeficiency states;
chronic bronchitis, pneumonia, and recurrent herpetic infections (combined therapy).

Prevention of postoperative infectious complications and the normalization of immune status. In the complex therapy of acute intestinal infection rotavirus in children older than 3 years.

Dosage regimen

The drug is prescribed inside, before eating. Single dose for adults and children over 12 years - 200 mg (2 capsules. 100 mg or 4 capsules. 50 mg) for children aged 6 to 12 years - 100 mg, 3 to 6 years - 50 mg.

To prevent nonspecific

In direct contact with sick flu and SARS in adults and children over 12 years Arbidol prescribe a dose of 200 mg / d for children aged 6 to 12 years - 100 mg / d for children aged 3 to 6 years - 50 mg / days. Take a drug once a day. Course - 10-14 days.

During epidemics of influenza and other viral respiratory infections, to prevent exacerbation of chronic bronchitis and recurrent genital herpes infections in adults and children over 12 years of drug administered in a single dose of 200 mg for children aged 6 to 12 years - 100 mg for children aged 3 to 6 years - 50 mg.

Drugs are taken 2 times a week for 3 weeks. For prevention of SARS (in contact with the sick) in adults and children over 12 years prescribed 200 mg 1 time / day for 12-14 days for children aged 6 to 12 years - 100 mg 1 time per day (before meals) within 12-14 days.

For the prevention of postoperative infectious complications in the drug prescribed for two days before surgery, then on the second and fifth day after surgery at doses: for adults and children over 12 years - 200 mg for children aged 6 to 12 years - 100 mg, 3 to 6 years - 50 mg.

For treatment

With flu and other respiratory viral infection without complications in adults and children over 12 years of drug prescribed at 200 mg 4 times a day (every 6 h), children aged 6 to 12 years - 100 mg 4 times a day (every 6 hours) from 3 to 6 years - 50 mg 4 times / day (every 6 h). The course of treatment - 5 days. With flu and other respiratory viral infection with the development of complications (including bronchitis, pneumonia) in adults and children over 12 years Arbidol prescribed 200 mg 4 times daily (every 6 h) within 5 days, then - 200 mg 1 time / week. 4 weeks.

Children aged 6 to 12 years prescribed for 100 mg 4 times / day (every 6 h), then - at 100 mg 1 time per week. 4 weeks.

Children aged 3 to 6 years appoint 50 mg 4 times / day (every 6 h) for 5 days, then - at 50 mg 1 time per week. 4 weeks.

For the treatment of SARS in adults and children over 12 years prescribed 200 mg 2 times / day for 8-10 days.

In the combined therapy of chronic bronchitis and recurrent genital herpes infections in adults and children over 12 years of drug prescribed at 200 mg 4 times a day (every 6 h) for 5-7 days, then - 200 mg 2 times / week. 4 weeks.

Children aged 6 to 12 years 100 mg 4 times / day (every 6 h) for 5-7 days, then - on 100 mg 2 times / week. 4 weeks. Children aged 3 to 6 years prescribed 50 mg 4 times / day (every 6 h) for 5-7 days, then - 50 mg 2 times / week. 4 weeks.

In the combined therapy of acute intestinal infection rotavirus children over 12 years to designate 200 mg 4 times a day (every 6 h) during 5 days, at the age of 6 to 12 years - 100 mg 4 times a day (every 6 h ) within 5 days, at the age of 3 to 6 years - 50 mg 4 times daily (every 6 h) within 5 days.

Side effect

Rare: allergic reaction.

Contraindications
Children under 3 years;
Hypersensitivity to the drug.

Pregnancy and lactation

Data on the use of arbidol during pregnancy and breastfeeding are not available.

Cautions

Effects on ability to drive vehicles and management mechanisms

The drug shows no central neurotropic activity and can be used in medical practice as a preventive measure in healthy persons of various professions that require attention and quickness of psychomotor reactions (including transport drivers, operators).

Overdose

An overdose of the drug is not registered. Drug Interactions With the appointment with other drugs adverse effects were observed.

Terms and Conditions of storage

List B. The drug should be stored out of reach of children, dry, dark place at temperatures not above 25 ° C. Shelf life - 2 years.