2010/09/21

Argosulfan

Composition, structure and packing

The cream for external use only 2% in the form of white or white tinged with pink to light-gray uniform with a soft mass.

1 g of silver sulphathiazole 20 mg.

Excipients: liquid paraffin, tsetostearilovy alcohol, petrolatum, sodium lauryl sulfate, glycerol, propilgidroksibenzoat, metilgidroksibenzoat, hydrophosphate potassium, sodium dihydrogen, water d / and.

Clinico-pharmacological group: preparation of antibacterial activity for outdoor use.

Pharmacological action

Drug with antibacterial activity for outdoor use. Promotes healing of wounds (including burns, trophic, purulent), provides effective protection from infection of wounds, reduces or eliminates the pain and burning sensation in the wound, reduces the preparation time wounds to skin grafts, in many cases leads to improved conditions, precluding the need for transplantation .

Incoming in the drug sulfanilamide - sulphathiazole silver antimicrobial bacteriostatic tool has a broad spectrum of activity against Gram-positive and Gram-negative bacteria. Mechanism of antimicrobial action sulphathiazole is inhibited the growth and reproduction of microorganisms as a result of competitive antagonism with para-aminobenzoic acid and oppression digidropteroatsintetazy, which leads to disruption of synthesis digidrofolievoy acid and, ultimately, its active metabolite - tetrahydrofolic acid, essential for the synthesis of purines and pyrimidines of the microbial cell .

Those present in the preparation of silver ions enhance antibacterial sulfanilamide - they inhibit the growth and division of bacteria by binding to deoxyribonucleic acid of microbial cells. In addition, the silver ions weaken the sensitizing properties of sulfanilamide.

Hydrophilic base cream, which has an optimum pH value and containing a large amount of water, provides a local analgesic effect and wetting wounds, promotes good portability, ease and accelerate wound healing. With minimal resorption of the drug has no toxic effect.

Pharmacokinetics

Absorption

Contained in the product sulphathiazole silver has a low solubility, resulting in concentration after local application of drugs in the wound for a long time maintained at the same level. Absorption sulphathiazole silver increases with the application of the drug on the extensive wound surfaces.

Distribution and metabolism

Only a small number sulphathiazole silver is in the bloodstream, and then subjected to acetylation in the liver.

Withdrawal

The urine is in the form of inactive metabolites and partly in unchanged form.

Statement
burns of all degrees of any etiology (including thermal, solar, chemical, electrical shock, radiation);
frostbite;
festering wounds;
minor personal injury (cuts, abrasions);
infected dermatitis (including simple contact dermatitis, impetigo, microbial eczema, streptostafilodermiya);
sores;
trophic crural ulcers of different genesis (including chronic venous insufficiency, occlusive disease, angiopathy in diabetes mellitus, erysipelas).

Dosage regimen

The drug is used topically as an open method, and in the form of occlusive dressings. After cleansing and debridement under conditions of sterility in the wound causing drug layer thickness of 2-3 mm, 2-3 times / day. Wound during treatment should be completely covered with cream. If part of the wound will need to further apply the cream.

The cream is applied to the complete healing of wounds or until skin grafting. If the result of applying the cream to the infected wound exudate appears, before re-applying the cream should be washed wound 0.1% aqueous chlorhexidine, 3% aqueous solution of boric acid or other antiseptic. The maximum daily dose - 25 g. The maximum duration of treatment - 60 days.

Side effect

Perhaps: allergic skin reaction (including burning, itching, flushing of the skin). With long-term use - leukopenia, deskvamatozny dermatitis.

Contraindications
congenital deficiency of the enzyme glucose-6-phosphate dehydrogenase;
prematurity, infants up to 2 months (due to the risk of "nuclear" jaundice);
Hypersensitivity to any component of the drug and other sulphonamide.

Pregnancy and lactation

Application Argosulfana during pregnancy and lactation is possible only in cases where the surface of the burn does not exceed 20% of body surface and the estimated benefit to the mother more than the possible risk to the fetus / child.

Application for violations of liver function

Precautions should be prescribed the drug to patients with disorders of the liver.

Application for violations of renal function

Precautions should be prescribed the drug to patients with impaired renal function.

Cautions

When hepatic and / or renal insufficiency should be monitored sulphathiazole concentration in blood serum. Precautions should be prescribed to patients in a state of shock, with extensive burns because of the inability to collect full allergic history.

Effects on ability to drive vehicles and management mechanisms

The drug has no effect on the activities of potentially hazardous activities that require high concentration and speed of psychomotor reactions (including driving a car).

Overdose

Currently, cases of overdosing Argosulfan not reported.

Drug Interactions

Not recommended for use in conjunction with other local medicines. Folic acid and its structural analogs can reduce the antimicrobial action sulphathiazole.

Terms and Conditions of storage

The drug should be stored out of reach of small children at or above 25 ° C; not freeze. Shelf life - 2 years.