2010/09/21

Anexate

Composition, structure and packing

Solution for i / in the introduction of a transparent colorless or nearly colorless, with no visible inclusions.

1 ml. flumazenil 100 mcg.

1 amp. flumazenil 500 mcg

Excipients: ethylenediaminetetraacetic acid, acetic acid, sodium chloride, sodium hydroxide, water d / and.

Clinico-pharmacological group: Competitive antagonist of benzodiazepines.

Pharmacological action

The specific antagonist of benzodiazepines (anxiolytic, hypnotic, and antiepileptic drugs). Blocks benzodiazepine receptors and eliminates (reduces) the effect of drugs benzodiazepine structure. Does not eliminate the effect of drugs which depress the central nervous system, if their effects are not due to the influence on benzodiazepine receptors.

Statement
removal of the central effects of benzodiazepines (restoring self-consciousness and breathing out of general anesthesia conducted with benzodiazepines; removal sedative action of benzodiazepines for diagnostic and therapeutic procedures, differential diagnosis for loss of consciousness of unknown etiology, poisoning, benzodiazepines).

Dosage regimen

I / O and diluted with 5% dextrose or 0.9% solution of NaCl. To derive from general anesthesia in an initial dose - 0.2 mg for 15 seconds, if necessary - to 0.1 mg at intervals of 1 min and the maximum dose - 1 mg, average dose - 0.3-0.6 mg.

In case of overdose of benzodiazepines: an initial dose - 0.3 mg, if necessary - again with the same dose at intervals of 1 min, maximum dose - 2 mg.

When confusion is introduced into / to drip, at a speed of 100-400 mg / h.

Side effect

Rash, "tides" of blood to the face, fear, anxiety, palpitations, nausea, vomiting, cramps, symptoms of benzodiazepine withdrawal.

Contraindications
hypersensitivity.

C carefully. Pregnancy (I term).

Pregnancy and lactation

The drug is taken with caution.

Cautions

Refrain within days after receiving from the work that requires increased attention. You should not assign patients with epilepsy who were treated with benzodiazepines. In such patients antagonistic action with respect to benzodiazepines can provoke the development of epileptic seizures.

In the I trimester of pregnancy application is permissible only if absolutely indicated.

It should be remembered that in patients with severe head injury or unstable intracranial pressure may develop intracranial hypertension.

Not recommended for use until the expiration of the peripheral muscle relaxant, in violation of the SSA and the autonomic nervous system in poisoning with tri-and tetracyclic antidepressants.

Drug Interactions

Blocks the action zopiklona, triazolpiridazinov on benzodiazepine receptors

Terms and Conditions of storage

Store at temperatures below 25 ° C.

Shelf life 5 years

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