2010/09/17

Allapanin

Composition, structure and packing

Tablets are white, biconvex, ploskotsilindricheskie.

1 tab. allapinine (hydrobromic salt alkaloid lappaconitine derived from a fighter and a fighter northern beloustogo) 25 mg.

Excipients: sugar, potato starch, calcium stearate.

Clinico-pharmacological group: antiarrhythmic drugs.

Pharmacological action

Class I antiarrhythmic agent. Blocks "fast" sodium channels of membranes of cardiomyocytes. It was slow AV-and intraventricular conduction, shortens the effective and functional refractory periods of atrial, AV-node, bundle of His and Purkinje fibers, did not affect the duration of the interval QT, the conductivity of AV-node in the anterograde direction, heart rate, blood pressure, myocardial contractility (for the initial absence of effects of heart failure). Not depresses automaticity of sinus node. There is no negative inotropic and hypotensive effect. Has a moderate spasmolytic, koronarorasshiryayuschee, anticholinergic, mestnoanesteziruyuschee and sedative effect. When administered effect develops in 40-60 minutes, reaching a maximum after 4-5 h and lasts 8 hours or more.

Pharmacokinetics

Absorption

Bioavailability is 40%. The drug undergoes the effect of "first pass" through the liver.

Distribution and metabolism

When administered Vd is 690 liters. Penetrates through the BBB.

Withdrawal

T1 / 2 of 1-1.2 h. Write the kidneys.

Pharmacokinetics in special clinical situations

Prolonged use may increase in T1 / 2. In chronic renal failure, T1 / 2 increases by 2-3 times, with cirrhosis of the liver - in 3-10 times.

Statement
supraventricular premature beats;
ventricular premature beats;
paroxysms of fibrillation and atrial flutter;
paroxysmal supraventricular tachycardia (including the syndrome WPW);
paroxysmal ventricular tachycardia (in the absence of organic heart disease).

Dosage regimen

Assign inside of 25 mg (1 tab.) 3 times / day. In the absence of therapeutic effect appoint 50 mg (2 tab.) 3-4 times / day. The maximum single dose - 150 mg daily dose - 300 mg. Duration of treatment is determined by your doctor. In chronic renal failure, severe reduction of the dose required allapinine. The drug is taken as 30 minutes before eating, drinking warm water. Before taking pills recommended crush.

Side effect

From the central nervous system and peripheral nervous system: dizziness, headache, feeling of heaviness in the head, ataxia, diplopia.

Since the cardiovascular system: possible congestion of the skin, violations AV-and intraventricular conduction, the appearance of sinus tachycardia (with prolonged use), arrhythmogenic effect.

Contraindications
AV-block II and III degree (without pacemaker);
Chronic heart failure;
hypertrophy of left ventricular (more than 1.4 cm);
the presence of infarction atherosclerosis;
marked disturbances of liver function;
pronounced renal dysfunction;
Pregnancy
lactation;
childhood and adolescence to 18 years;
Hypersensitivity to the drug.

With caution and under close medical supervision, starting treatment in hospital, should be applied to AV-blockade of I degree, violation of intraventricular conduction, SSS, bradycardia, severe circulatory disorders.

Pregnancy and lactation

The drug is contraindicated during pregnancy and lactation.

Application for violations of liver function

Contraindications disturbancies liver function.

Application for violations of renal function

In chronic renal failure requires dose reduction allapinine.

Cautions

If you have a headache, dizziness, diplopia should reduce the dose of the drug. When sinus tachycardia against a background of prolonged administration of the drug illustrated the use of beta-blockers in low doses.

Overdose

Data on overdose allapinine not available.

Drug Interactions

When applied simultaneously with inducers of microsomal liver enzymes allapinine efficiency decreases. Antiarrhythmics, other classes increase the risk of arrhythmogenic action. Allapinine intensifies the effect of nondepolarizing muscle relaxants.

Terms and Conditions of storage

List B. The drug should be stored protected from light and the reach of children. Shelf life - 3 years.