2010/09/17

Actinerval

Composition, structure and packing

Tablets are white, round, biconvex, with a dividing notch and the letters "ACT" on one side and the logo of the company - on the other.

1 tab. carbamazepine 200 mg.

Pharmacological action

Antiepileptic, anticonvulsant, normotimicheskoe, antipsychotic, antidepressant agent.

Statement
epilepsy (except petit mal),
manic states
prophylaxis of manic-depressive disorders
alcohol withdrawal,
Trigeminal neuralgia and linguistic pharyngeal nerves
diabetic neuropathy.

Dosage regimen

The drug is taken by mouth, adult - 100-1600 mg. per day (depending on the indications and severity of illness), children - 10-20 mg / kg / day in divided doses.

Side effect

Dizziness, agitation, hallucinations, depression, aggressive behavior, activation of psychosis, headache, diplopia, accommodation disturbances, cataract, nystagmus, conjunctivitis, tinnitus, changes in taste sensations, speech disturbances (dysarthria, slurred speech), abnormal involuntary movements, peripheral neuritis, paresthesia, muscle weakness and symptoms of paresis, AV block, congestive heart failure, hyper-or hypotension, thromboembolism, renal dysfunction, interstitial nephritis, nausea, vomiting, increased liver enzymes, jaundice, hepatitis, osteomalacia, Sexual Dysfunction, moderate leukopenia, thrombocytopenia, blood violations, hyponatremia, multiorgan hypersensitivity reaction of delayed type, exfoliative dermatitis, volchanochnopodobny syndrome (skin rash, urticaria, pyrexia, sore throat, joint pain, weakness), a syndrome of Stevens - Johnson, toxic epidermal necrolysis, anaphylactic reactions.

Contraindications
Hypersensitivity (including to the tricyclic antidepressants)
AV block,
myelosuppression or acute porphyria in history,
pregnancy (I term).

Pregnancy and lactation

The drug is not used (I trimester)

Cautions

Before and during therapy are recommended regular blood tests (cellular elements) and urine monitoring indicators of liver function. With caution is prescribed for the presence of a history of heart disease, liver or kidney disease, with hematological disorders, increased intraocular pressure, latent psychosis, inadequate response to external stimuli, anxiety, illness, characterized by spasms of mixed character, the elderly, drivers of vehicles and persons exploiting mechanisms. You should not abruptly discontinue therapy. Women are encouraged to additional folic acid (before the onset of pregnancy or during her) in order to prevent bleeding disorders in the last weeks of pregnancy and in newborns may use vitamin K.

Overdose

Symptoms: disorientation, drowsiness, agitation, hallucinations and coma, blurred vision, dysarthria, nystagmus, ataxia, dyskinesia, giper-/giporefleksiya, seizures, myoclonus, hypothermia, respiratory depression, pulmonary edema, tachycardia, gipo-/gipertenziya, heart failure, accompanied by loss of consciousness, vomiting, decrease in motility of the colon, fluid retention, oligouriya or anuria, changes in laboratory parameters: hyponatremia, possible metabolic acidosis, hyperglycemia, increase muscle fraction kreatininfosfokinazy.

Treatment: induction of vomiting or gastric lavage, the appointment of activated charcoal and saline laxatives, forced diuresis.

To maintain the airway - intubation of the trachea, artificial respiration and (or) the use of oxygen.

If hypotension or shock - Plasma dopamine or dobutamine, with the appearance of convulsions - the introduction of benzodiazepines (diazepam) or other anticonvulsants (in children may be increased respiratory depression in the development of hyponatremia - water deprivation, cautious in / infusion of isotonic sodium chloride solution.

With a combination of severe poisoning with renal failure shows renal dialysis. The specific antidote is available.

It should anticipate the re-intensification of symptoms of overdose for 2 nd and 3 rd day after it began, owing to the slow absorption of the drug.

Drug Interactions

Incompatible with MAO inhibitors. Increases hepatotoxicity of isoniazid. Decreases effects of anticoagulants, anticonvulsants (hydantoin or succinimide derivatives), barbiturates, clonazepam, primidona, valproic acid. Phenothiazines, pimozid, thioxanthenes increase CNS depression (decreased convulsive threshold), cimetidine, clarithromycin, diltiazem, verapamil, erythromycin, propoxyphene reduce metabolism (increases the risk of toxic action). It lowers the activity of corticosteroids, estrogens and estrogensoderzhaschih oral contraceptives, quinidine, cardiac glycosides (induction of metabolism). Against the background of carbonic anhydrase inhibitors increases the risk of violations of osteogenesis.

Terms and Conditions of storage

In a dry, dark place, at temperatures up to 25 ° C. Shelf life 2 years