Composition, structure and packing

Tablets are white, oval, biconvex, with a dividing notch on both sides.

1 tab. Loratadine 10 mg.

syrup, a suspension for oral

Clinico-pharmacological group: blocker histamine H1-receptors. Antiallergic drug.

Pharmacological action

Blocker H1-histamine receptor (long-acting). Inhibits release of histamine and leukotriene C4 from mast cells. Prevents the development and facilitates during allergic reactions. It has anti-allergic, antipruritic, protivoekssudativnym action. Decreases capillary permeability, prevents the development of edema, relieves spasms of smooth muscles.

Antiallergic effect develops after 30 minutes, reaching a peak after 8-12 h and lasts for 24 hours no effect on the CNS and non-addictive (as they do not penetrate the BBB).

allergic rhinitis (seasonal and year-round)
urticaria (including chronic idiopathic)
itching dermatosis;
psevdoallergicheskie reaction
induced histamine release;
allergic reactions to insect bites.

Dosage regimen

Adults and children weighing over 30 kg - 10 mg 1 time per day.

In liver failure the initial dose - 5 mg / day.

Children from 2 to 12 years weighing less than 30 kg - 5 mg / day in 1 device.

Side effect

Adverse events occurred with approximately the same frequency as the application with placebo.

In adults: headache, fatigue, dry mouth, drowsiness, nausea, gastritis, allergic reactions (hives), anaphylaxis, alopecia, abnormal liver function.

Children: headache, increased nervous irritability, sedation.


C carefully. Hepatic failure, pregnancy.

Pregnancy and lactation

The application is only possible if the intended benefits to the mother outweighs the potential risk to the fetus and newborn.


During the period of treatment must be careful when driving and other lesson potentially dangerous activities which require high concentration and speed of psychomotor reactions.


Symptoms: headache, drowsiness, tachycardia.

In children weighing less than 30 kg when taking syrup in a dose over 10 mg marked extrapyramidal disorders, palpitations.

Treatment: induction of vomiting Ipecacuanha syrup, gastric lavage, the appointment of activated charcoal, symptomatic and supportive therapy. Hemodialysis is ineffective.

Drug Interactions

Inhibitors of CYP3A4 (including ketoconazole, erythromycin), inhibitors of CYP3A4 and CYP2D6 (cimetidine, etc.) increase the concentration of loratadine in the blood.

Inductors microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, fenilbutazon, tricyclic antidepressants) reduce the effectiveness.

Terms and Conditions of storage

Store in a dry, dark place at a temperature of 25 ° C.

Shelf life 2 years