2010/09/17

Alerza

Composition, structure and packing

Drops for oral administration

Solution for oral administration

Jules

Film-coated tablets: white to creamy-white, kapsulovidnoy form, with the separation scored on one side and embossed "B" and "L", on the other side embossed with "10".

1 tab. cetirizine hydrochloride 10 mg.

Clinico-pharmacological group: blocker histamine H1-receptors. Antiallergic drug.

Pharmacological action

Competitive antagonist of histamine, a metabolite Hydroxyzine blocks H1-histamine receptors. Prevents the development and facilitates during allergic reactions, has antipruritic and protivoekssudativnym action. Influences on the early stage of allergic reactions, limits the release of inflammatory mediators in the "late" stage of allergic reactions, reduces the migration of eosinophils, neutrophils and basophils. Decreases capillary permeability, prevents the development of edema, relieves spasm of smooth muscles. Eliminates skin reaction to the introduction of histamine, specific allergens, as well as on cooling (in cold urticaria). Reduces gistaminoindutsirovannuyu bronhokonstriktsiyu bronchial asthma lung flow. Almost no anticholinergic and antiserotoninovogo action. In therapeutic doses, is virtually sedative effect. Start effect after single dose of 10 mg. cetirizine - 20 min. (50% of patients) and after 60 min (95% of patients), continues for more than 24 hours on the background of course of treatment, tolerance to the antihistaminic action of cetirizine is not developed. After the cessation of treatment effect persists up to 3 days.

Statement
seasonal and perennial allergic rhinitis and conjunctivitis (itching, sneezing, rhinorrhea, lacrimation, conjunctival hyperemia),
urticaria (including chronic idiopathic urticaria),
hay fever
dermatitis,
pruritus,
angioedema,
atopic asthma (in the complex therapy).

Dosage regimen

The drug, taken orally, tablets is drunk 200 ml of water drops before taking dissolved in water.

Adults and children over 6 years - 10 mg 1 time per day or 5 mg 2 times a day, children 2-6 years old - 5 mg 1 time per day or 2.5 mg 2 times a day, children 1-2 years old - 2.5 mg (5 Cap) 2 times a day.

In patients with decreased renal function (CC 30-49 ml / min) designate 5 mg / day, with severe chronic renal failure (CC 10-30 ml / min) - 5 mg / day every other day.

Side effect

Drowsiness, dry mouth, seldom - headache, dizziness, headache, gastrointestinal discomfort, allergic reactions (angioedema, rash, urticaria, pruritus).

Contraindications
hypersensitivity (including to hydroxizine)
pregnancy
lactation.

C carefully. Chronic renal failure (moderate to severe intensity - required correction dosing regimen), advanced age (may decrease glomerular filtration), children's age (experience of use in children under 1 year is not enough

Pregnancy and lactation

Acceptance of the drug is contraindicated.

Cautions

In excessive doses of 10 mg / day capacity for rapid reaction can occur. In recommended doses does not increase the action of ethanol (a concentration not exceeding 0.8 g / l), nevertheless it is recommended to refrain from its use during the treatment.

During the period of treatment must be careful when driving and other lesson potentially dangerous activities which require high concentration and speed of psychomotor reactions.

Overdose.

Symptoms (occur when receiving a single dose of 50 mg) - dry mouth, drowsiness, urinary retention, constipation, anxiety, irritability.

Treatment: gastric lavage, the appointment of symptomatic drugs. Specific antidote exists. Hemodialysis is ineffective.

Drug Interactions

Pharmacokinetic interactions with pseudoephedrine, cimetidine, ketoconazole, erythromycin, azithromycin, diazepam and glipizidom not found.

Joint appointment with theophylline (400 mg / day) leads to a decrease in the overall clearance of cetirizine (kinetics of theophylline does not change). Myelotoxic drugs increase the expression gematotoksichnosti drug.

Terms and Conditions of storage

Store in a dry place protected from light, at temperatures not above 25 ° C.

Shelf life 3 years