2010/06/05

NAZOFERON

Pharmacological properties: The product is based on recombinant human interferon alfa-2b, antiviral, antimicrobial, anti-inflammatory and immunomodulatory agent. The biological effect of interferon is characterized by such effects: inhibits the replication of viruses (adenovirus, influenza virus, etc.) due to the inhibitory effect on the processes of transcription and translation; antiproliferative - inhibits the proliferation of cells infected with viruses (the majority of DNA and RNA viruses). Interferon initiates the synthesis of a specific enzyme - protein kinase, which prevents translation through phosphorylation of one of the triggers of this process, activates specific ribonuclease, damaging the messenger RNA of the virus. To the effects of interferon are also: stimulation of production of other cytokines, induction of specific enzymes, inhibition of cell proliferation, immunomodulation (increased phagocytic activity of macrophages and the specific cytotoxicity of lymphocytes in relation to the target cells). Interferon is a mediator of immunity and has a distinct tissue specificity. Due to its effects, interferon protects the body from infectious agents (viruses, bacteria, mycoplasma, pathogenic fungi, etc.).

INDICATIONS: Treatment of influenza and other viral respiratory infections, colds in children (from birth) and adults (including pregnant women) in patients suffering from frequent and prolonged upper respiratory tract infections;

prevention of viral infections through contact with patients with influenza and other viral respiratory infections, with supercooling, seasonal increases in incidence in organized groups (children and adults), among the contingent risk (health care workers, teachers and others, especially during epidemics).

APPLICATION: injected into each nasal passage, respectively, the method of application and dosage. After instillation is recommended to massage his fingers in the nostrils for a few minutes to distribute the drug in the nasal cavity.

At the first sign of the flu and other respiratory viral infection (for 5 days):

infants and children under the age of 1 year - 1 drop 5 times a day (single dose - 8000 IU daily dose - 40 000 IU);

Children over 1-3 years - 2 drops (dose spray) 3-4 times per day (single dose: drop - 16 000 IU, Spray - 20 000 IU daily dose: drop - 48 000-64 000 IU, spray - 60 000-80 000 IU);

Children over 3-14 years - 2 drops (dose spray) 4-5 times per day (single dose: drop - 16 000 IU, Spray - 20 000 IU daily dose: drop - 64 000-80 000 IU, spray - 80 000-100 000 IU);

adults - 3 drops (dose spray) 5-6 times per day (single dose: drop - 24 000 IU, Spray - 30 000 IU daily dose: drop - 120 000-144 000 IU, Spray - 150 000-180 000 IU).

For prevention of respiratory viral infections:

in contact with sick and supercooling - in accordance with the age-dose 2 times for 5-7 days. If necessary, repeat prevention courses. For a single contact only one instillation (injection).

With the seasonal increase in morbidity - in accordance with the age-dose once in the morning with an interval of 1-2 days.

Contraindications: individual intolerance of drugs interferon and other components of the drug, severe forms of allergic diseases in history.

SIDE EFFECTS: not identified.

SPECIAL PRECAUTIONS: The safety of the drug Nazoferon allows it to be recommended during lactation, as well as in obstetrics - pregnancy, since it is especially important to prevent viral infection in the I trimester of pregnancy, which may lead to the development of malformations in the fetus.

INTERACTION: In uncomplicated cases, the use of Nazoferona additional symptomatic treatment (paracetamol, sulfonamides, vasoconstrictive nasal drops) are usually not required. With the use of fever medication can be combined with NSAID intake / antipyretics. Simultaneous intranasal application of vasoconstrictive agents is not recommended (promotes additional drying of the mucous membrane of the nasal cavity).

OVERDOSE: not marked.

Storage: Store in a dry place protected from light at 2-8 ° C. Shelf life after opening the bottle - no more than 10 days.