2010/06/05

GLATIRAMER ACETATE

Pharmacological action

Immunomodulator. It is a mixture of synthetic polypeptides formed by amino acids: L-glutamine, L-alanine, L-tyrosine and L-lysine. Copolymers of these amino acids have structural similarity to myelin basic protein - the main component of myelin sheaths, which are destroyed in multiple sclerosis. Modifies the immune response and effect on immunocompetent cells.

Competes with myelin proteins and myelin and glycoprotein oligodendrotsitarnym proteolipidnym protein for binding with molecules of the main histocompatibility complex class II on the surface of cells bearing the antigens.

It stimulates the formation of antigen T-lymphocytes. Blocks mielinspetsificheskie autoimmune response, causing the destruction of myelin sheaths of nerve fibers (demyelination) in multiple sclerosis. When treating patients with multiple sclerosis remittent flow reduces the frequency of relapses and slows the onset of irreversible neurological disorders.


Pharmacokinetics

After sc administration of locally hydrolyzed much of glatiramer acetate. Some of the active substance penetrates into the lymphatic system and the small amount goes into the systemic circulation unchanged.


Statement

Multiple sclerosis remittent course.


Dosage regimen

Enter n / a dose of 20 mg 1 time per day every day at the same time. Treatment of long-term.


Side effect

From the CNS: asthenia, headache, anxiety, loss of consciousness, tremor.

Since the cardiovascular system: flushing, feeling of heaviness and pain in the chest, palpitations, arrhythmia, vasodilation, increased blood pressure.

On the part of the digestive system: loss of appetite, nausea, vomiting, diarrhea, difficulty swallowing, thrush.

From the senses: vertigo, nystagmus, visual disturbances.

On the part of the respiratory system: dyspnea, shortness of breath, ARI, laryngism, bronchitis, hyperventilation.

On the part of the reproductive system: dysmenorrhea, reduction of potency.

From the urinary system: peripheral edema, hematuria, questionable test results on Pap.

Allergic reactions: urticaria, angioedema.

Local reactions: flushing, swelling, itching skin, pain at the injection site.

Other: arthralgia, lymphadenopathy, back pain, increased sweating, flu-like syndrome.


Contraindications

Pregnancy, lactation, childhood and adolescence to 18 years, hypersensitivity to glatiramer acetate.


Application of pregnancy and breastfeeding

There are no adequate and well-controlled studies safety glatiramer acetate in pregnancy has not been.

It is not known whether glatiramer acetate is allocated with breast milk, so if you need to use during lactation should stop breastfeeding.

In experimental studies found no mutagenic effects of glatiramer acetate and its negative impact on the reproductive system, the development of the embryo and the process of childbirth.


Cautions

The maximum therapeutic effect is achieved at the beginning of treatment at an early stage of the disease.


Drug Interactions

Drug interaction is not established.