2010/06/05

FOLLITROPIN ALFA

Pharmacological action

Recombinant FSH produced by genetic engineering of cells of Chinese hamster ovary. It stimulates the formation of follicles. Effects due to the fact that parenteral administration follitropina alpha is formed mature graafovyh bubbles.


Statement

Anovulyatornoe infertility, hypothalamic-pituitary disorders - oligomenorrhea, amenorrhea (including with polycystic ovaries), stimulation of superovulation (stimulating the growth of multiple follicles) in the technology subsidiary of methods of reproduction.


Dosage regimen

Solo, depending on the applied treatment regimens.


Side effect

Perhaps: ectopic pregnancy (in women with a history of tubal disease), multiple pregnancy, ovarian hyperstimulation syndrome, fever, arthralgia, at the injection site - the pain and congestion.

Rare: thromboembolism, and allergic reactions.


Contraindications

The increase in ovary or ovarian cyst, not associated with polycystic ovary syndrome, gynecological hemorrhage of unknown etiology; carcinoma of the ovary, uterine or breast cancer; tumor of the hypothalamus or pituitary, absence of an oocyte order, improper development of sexual organs incompatible with pregnancy, uterine fibroid, which is incompatible with pregnancy, pregnancy, hypersensitivity to follitropinu alpha.


Cautions

Prior to treatment should be to establish the existence of marital infertility and possible contraindications to pregnancy. Must be excluded concomitant endocrine diseases (hypothyroidism, adrenal insufficiency, hyperprolactinemia, the swelling of the hypothalamus and pituitary).

In appointing chHG increases the possibility of ovarian hyperstimulation syndrome, so if you over-estrogen response chHG not appointed, and patients to refrain from coitus for at least 4 days. The probability of occurrence of hyperstimulation can be reduced by aspiration of all follicles before ovulation.

The risk of multiple pregnancy during assisted reproduction is associated with a number of substituted oocytes / embryos, with most cases of multiple conceptions are twins made it.


Drug Interactions

When applied simultaneously with other drugs to stimulate ovulation may increase the reaction of the follicles, whereas simultaneous pituitary desensitization GnRH agonist can lead to the need to increase the dose follitropina alpha, which causes an adequate response of the ovaries.