2010/06/05

ASPECARDUM

Pharmacological properties: Aspekard has antithrombotic and anti-inflammatory, antipyretic and analgesic action, characteristic of acetylsalicylic acid. The mechanism of action of acetylsalicylic acid is the inactivation of the enzyme COX, resulting in disturbed synthesis of prostaglandins, prostacyclin and thromboxane. Due to lower production of prostaglandins decreases their pyrogenic effects on thermoregulation center. Reduces sensitizing effect of prostaglandins on the sensitive nerve endings, which reduces their sensitivity to the mediators of pain. Irreversible disruption of the synthesis of platelet thromboxane A 2 determines the antiplatelet effect of acetylsalicylic acid.

Absorption of acetylsalicylic acid in the digestive tract occurs rapidly and completely. The maximum level of concentration in plasma is reached after 10-20 min. The degree of binding to plasma proteins depends on the concentration and amounts to 49-70%. About 50% of acetylsalicylic acid is metabolized during the initial passage through the liver. Outputs in the form of metabolites in the urine. The half-life of salicylic acid is 20 minutes and increases with increasing dose. Penetrates through the BBB in the CSF, synovial fluid, breast milk.

Indication: Used as a means antiaggregant unstable angina, acute myocardial infarction and for secondary prevention of myocardial infarction, thrombosis and embolism after surgical interventions on blood vessels (coronary artery bypass grafting, percutaneous transluminal coronary angioplasty), transient cerebral circulatory disorders and ischemic stroke, thrombosis coronary arteries.

USE: 1 tablet 1 time a day after meals. For secondary prevention of myocardial infarction dose can be increased to 2-3 tablets a day for 2-3 months. The drug is intended for long-term use (1-2 months to 2 years), duration of which is determined individually. To reduce the intensity of the stimulating effect of the drug on the mucous membrane of the stomach pills Aspekard taken after meals, washed down with 1 / 2 cup water or milk. The maximum daily dose is 300 mg.

CONTRAINDICATIONS: hypocoagulation, hemophilia, hemorrhagic diathesis, a predisposition to bleeding, erosive and ulcerative lesions of the digestive tract in acute, hypersensitive to salicylates, during pregnancy and lactation, abnormal liver function and kidney disease, the age of 14 years.

SIDE EFFECTS: from the gastrointestinal tract: abdominal pain, mikrogemorragii, nausea, vomiting, diarrhea, discomfort in the epigastric region, erosive and ulcerative lesions of the stomach, stomach bleeding, liver problems;

from the blood system: thrombocytopenia, anemia;

from the urinary tract: renal dysfunction;

Allergic reactions: skin rash, itching, hives;

by metabolic: hypoglycemia.

Cautions: Aspekard with caution and subject to constant supervision of doctors prescribe to patients with asthma, while therapy with anticoagulants (coumarin derivatives or heparin), and drug allergy and gastric ulcer and duodenal ulcer in history, with kidney disease, severe liver problems.

Aspekard may provoke the development of asthma in patients with allergic diseases (pollinosis, allergic rhinosinusitis, laryngitis, tracheobronchitis), as well as the presence of chronic respiratory tract infections, sensitivity to NSAID. When conducting long-term therapy or use of the drug in high doses required medical supervision and regular monitoring of blood clotting time, determining the number of platelets, the level of urea in the blood and urine analysis of occult blood.

Prolonged uncontrolled use of analgesics, especially when combining several drugs Aspekard can cause severe renal dysfunction until nephropathy.

On the application Aspekard before surgical or dental procedures should inform your doctor.

In children and adolescents with fever infectious inflammatory genesis in infectious-allergic myocarditis, pain weak and moderate intensity of acetylsalicylic acid should be used under medical supervision no more than 2 weeks.

INTERACTION: Aspekard enhances the action of anticoagulants, NSAIDs and antirheumatic, oral gipoglikemiziruyuschih drugs (sulfonylurea derivatives), methotrexate triiodothyronine. In the application of the SCS and ethanol increases the probability of ulcerogenic effect of the drug and the risk of gastrointestinal bleeding. Aspekard increases the concentration of digoxin, barbiturates and lithium salts in the blood plasma. The drug reduces the effect of diuretics (spironolactone, furosemide), urikozuricheskih funds (sulfinpirazon, probenecid, Etamid), antihypertensive drugs (captopril, atenolol, propranolol). Not recommended for use with antacid medications.

OVERDOSE: with a mild degree of intoxication may be nausea, vomiting, pain in the epigastric region, tinnitus, dizziness, headache, reduced vision and hearing (especially in children and elderly patients). In a large overdose mark incoherent thinking, confusion, drowsiness, collapse, tremors, shortness of breath, choking, rapid dehydration (decrease in buffer capacity of tissue fluid), hyperthermia, coma, alkaline urine, disturbance of acid-base balance (respiratory alkalosis initially, then - metabolic acidosis), glucose metabolism (decrease in blood glucose levels). The lethal dose of aspirin for adults - more than 10 g for children - 3 years depending on the condition of acid-base balance and electrolyte infusion introduction of p-ing sodium bicarbonate, sodium citrate or sodium lactate.

Storage: Store in a dry place protected from light at 25 ° C.