2010/12/17

Betoptic

Release form, composition and packing Betoptic 

Eye drops 0.5% in a clear, colorless or slightly yellow solution. 1 ml of betaxolol hydrochloride 5.6 mg, which corresponds to the content betaxolol 5 mg Excipients: benzalkonium chloride, hydrochloric acid and / or sodium hydroxide solution (to maintain the pH), purified water.

Clinico-pharmacological group: antiglaucoma medication - beta-blocker.

Pharmacological action

Antiglaucoma medication. Selective beta1-blocker without intrinsic sympathomimetic activity. Has no membrane stabilizing (local-anesthetic) action. When topically applied betaxolol reduces intraocular pressure by decreasing production of intraocular fluid. The onset of hypotensive action observed within 30 min after instillation, the maximum effect develops in 2 hours

After a single instillation of an impact on ophthalmotonus stored for 12 hours betaxolol (compared with other beta-blockers) did not induce reduction of blood flow to the optic nerve. Application Betoptika did not cause miosis, spasm of accommodation, night blindness, the effect of "veil" in front of the eyes (unlike miotikov).

Pharmacokinetics

When topical treatment is possible systemic absorption of betaxolol hydrochloride.

Statement

The drug is used to reduce intraocular pressure as monotherapy or in combination with other medications for:
open-angle glaucoma;
ocular hypertension.

Betoptik be used to treat open-angle glaucoma or ocular hypertension in patients with diseases of the respiratory system.

Dosing regimen

The drug is instilled into the conjunctival sac 1-2 drops 2 times a day. In some patients, stabilization of intraocular pressure occurs within a few weeks, so it is recommended to control intraocular pressure during the first month of treatment. In case of insufficient clinical efficacy of monotherapy prescribe additional therapy.

Side effect
On the part of the vision: often - short-term discomfort in the eyes after instillation, tearing, and in some cases - reducing the sensitivity of the cornea, redness of the eye, point keratitis, photophobia, anisocoria, photophobia, itching, dryness of the eyes.
CNS: Rarely - insomnia, depressive neurosis.

Contraindications
hypersensitivity to the drug.

Precautions should be prescribed the drug for sinus bradycardia, AV-block II and III degree of cardiac failure, cardiogenic shock, myasthenia gravis, diabetes mellitus.

Pregnancy and lactation

Enough experience with the drug Betoptik during pregnancy and lactation no. Use of the drug during pregnancy and lactation (breastfeeding) is possible only when the intended benefits to the mother outweighs the potential risk to the fetus or child.

Cautions

With carefully administered to patients with diabetes, because beta-blockers may mask the symptoms of acute hypoglycemia.

With carefully administered to patients with thyrotoxicosis, because Beta-blockers may mask the symptoms of hyperthyroidism (eg tachycardia). In patients with suspected thyrotoxicosis should not be abruptly canceled beta-blockers, as it may cause increased symptoms.

Keep in mind that beta-blockers can cause symptoms similar to those in infants (diplopia, ptosis, generalized weakness). Precautions should be prescribed beta-blockers in patients with severe impairment of respiratory system.

Despite the fact that clinical studies have shown no effect of betaxolol on lung function, we can not exclude the possibility of hypersensitivity to the drug. Before elective surgery should be phased out of beta-blockers for 48 hours before general anesthesia because during general anesthesia, they can reduce the sensitivity of the myocardium to sympathetic stimulation. Patients who used beta-blockers, may have a history of atopy or anaphylactic reactions. In the case of repeated hypersensitivity reactions, such patients may not be sensitive to the usual doses of epinephrine (adrenaline), required for relief of anaphylaxis.

The drug should be administered with caution in patients with Raynaud's syndrome or pheochromocytoma. When backfilling in the eye of beta-blockers may be absorbed into the systemic circulation.

At the same time may experience the same side effects as in the system application. There are cases of severe respiratory and cardiovascular disorders, including fatal bronchospasm in patients with bronchial asthma and death from heart failure. Betoptik has minimal effect on blood pressure and heart rate. However, caution should be exercised in the appointment of the drug to patients with AV-block or heart failure.

Treatment Betoptikom should immediately stop when the first symptoms of decompensation of the cardiovascular system.

Use caution when sharing application Betoptika and adrenergic psychotropic drugs. Eye drops Betoptik contain preservatives that may be deposited in soft contact lenses and have a damaging effect on the tissue of the eye. Therefore, patients who wear contact lenses should remove them before applying the drops and set back no earlier than 20 minutes after instillation.

Use in pediatrics

Enough experience with the drug Betoptik have no children.

Effects on ability to drive vehicles and management mechanisms

If, after drops in patients temporarily reduced clarity of vision, until its reconstruction is not recommended to drive and engage in activities that require attention and response.

Overdose

In eyes of excess drug should be flush eyes with lukewarm water.

Drug Interactions

With the simultaneous application of the drug Betoptik and beta-blockers for intake increases the risk of side effects (both local and systemic) due to the additive effect (so patients receiving this combination of drugs should be under medical supervision).

In applying Betoptika in combination with drugs, depletes catecholamines (such as reserpine), may see the decline of blood pressure and bradycardia.

Conditions and terms of

List B. The drug should be stored at a temperature of 8 ° to 30 ° C in places inaccessible to children. Shelf life - 3 years. After opening the bottle of medication must be used within 1 month.