2010/12/17

Betadrin

Release form, composition and packing Betadrin 

Eye drops are transparent, colorless. 1 ml of diphenhydramine hydrochloride, 1 mg nafazolina nitrate 330 mg Inactive ingredients: boric acid, benzalkonium chloride, Disodium EDTA, purified water.

Clinico-pharmacological group: drug with antiallergic and vasoconstrictor action for local use in ophthalmology.

Pharmacological action

Combined preparation for topical use in ophthalmology. Diphenhydramine is an antagonist of histamine H1-receptors of the first generation. Reduces allergy symptoms caused by histamine release (including increased capillary permeability).

Nafazolin - alpha-adrenoceptor agonists, when applied topically has a vasoconstrictor effect. Therapeutic effect develops within 5 minutes after instillation of the drug and lasts up to 8 hours, with frequent use of the drug duration may be shortened to 6 hours

Pharmacokinetics

When applied topically nafazolin can be absorbed into the systemic circulation and provide a systemic effect. Most likely to develop systemic effects in children under 6 years of age and the elderly.

System action diphenhydramine unlikely.

Statement
exacerbation of seasonal allergic conjunctivitis;
exacerbation of perennial allergic conjunctivitis;
irritation of the conjunctiva in the application of contact lenses;
irritation of the conjunctiva under the influence of external factors (including sunlight, cigarette smoke, water in the swimming pool).

Dosing regimen

Adults and children over 2 years are designated 1-2 drops into the lower conjunctival sac, no more than every 6-8 hours Duration of treatment - 3-5 days. The need for more long-term treatment determined by the physician individually in each case.

Side effect
On the part of the vision: often - burning, itching, eye pain, blurred vision, redness of the conjunctiva; possible mydriasis, increased intraocular pressure.

A case of corneal opacity in the application Betadrina within 7 days of at least 10 times a day (after the drug haze has disappeared).

Systemic reactions: seldom - drowsiness, tachycardia, increased blood pressure, headaches, dizziness, and nausea.

Contraindications
angle-closure glaucoma;
hyperthyroidism;
Children up to age 2 years;
pregnancy;
lactation;
hypersensitivity to the drug.

Pregnancy and lactation

Betadrin contraindicated in pregnancy. It is not known whether diphenhydramine and allocated nafazolin with breast milk, so if you need to use during lactation should decide the issue of termination of breastfeeding.

Cautions

With carefully administered to patients with hypertension, atherosclerosis, arrhythmia, chronic rhinitis, bronchial asthma, as well as the elderly. If during treatment with long lasting symptoms of local irritation or the development of systemic reactions, the drug should be discontinued.

Patients should be warned that without a doctor's prescription should not use the drug for more than 5 days or at intervals of less than 3 hours

Patients should be warned about the need to repeal the drug when symptoms persist or irritation oftalmalgii on therapy for more than 72 hours System action components Betadrina unlikely, but it should be used with caution on patients with hypertension, and cardiac arrhythmia, heightened sensitivity to sympathomimetics ( including in hyperthyroidism, prostatic hypertrophy), as well as in elderly patients.

Patients should be warned that in case of any symptoms that indicate a systemic effect of the drug, you must stop using Betadrina and seek medical advice.

Using the drug is not recommended to wear soft contact lenses. Before the instillation of eye drops should be removed hard contact lenses, set them up again you can at least 15-20 minutes after treatment. It is not recommended to touch the tip of the dropper, as it can cause contamination of eye drops.

Effects on ability to drive vehicles and management mechanisms

Patients who after treatment temporarily lost visual acuity, you should not drive vehicles and working with machines immediately after the instillation of eye drops.

Overdose

Symptoms: Data on overdose at instillation of eye drops in the conjunctival sac absent. For prolonged or too frequent use of the drug in children under 6 years are possible functions of the central nervous system depression, prolonged mydriasis, hypothermia, increased blood pressure.

Treatment: symptomatic therapy of conduct.

Drug Interactions

In the application of preparations containing nafazolin, during treatment with tricyclic antidepressants may increase vasoconstrictive action nafazolina. While the application nafazolina with MAO inhibitors and in the period to 10 days after its cancellation may develop a hypertensive crisis.

Conditions and terms of

List B. The drug should be kept in the dark and away from children at a temperature of 15 ° to 25 ° C. Shelf life - 3 years. After opening the vial shelf life - 4 weeks.