2010/12/17

Betaleukin

Release form, composition and packing Betaleukin 

Powder for injection 1 amp. / 1 fl. interleukin-1β 0.05 mg - - 0.5 mg - - 1 mg.

Stabilizer: PVP low molecular weight.

Clinico-pharmacological group: Stimulant leykopoeza. Immunostimulating drug.

Pharmacological action

Stimulant leykopoeza. Has gemostimuliruyuschee and immunostimulatory effects. The drug increases leykopoez and restores the bone marrow hemopoiesis after the damaging effect of cytotoxic drugs and radiation, due to its ability to induce production of colony-stimulating factor and increase proliferation and differentiation of hematopoietic cells of various germs.

Immunostimulatory effect of the drug due to increased functional activity of neutrophils, induction of differentiation of precursors of immune cells, increased lymphocyte proliferation, activation of cytokine production and increased production of antibodies.

Pharmacokinetics

Data on the pharmacokinetics of the drug Betaleukin not given.

Statement
stimulation leykopoeza with toxic leukopenia 2.4 degree, complicating chemo-and radiotherapy of malignant tumors;
patronage leykopoeza when the need for chemotherapy for leukopenia (leukocyte count of peripheral blood at least 3h109 / l);
secondary immunodeficiency that develops after severe trauma, extensive surgery, resulting in septic, purulent-destructive, chronic septic processes.

Dosing regimen

Betaleukin injected sc or iv infusion. To stimulate leykopoeza drug is used at a dose of 15-20 ng / kg body weight, to stimulate the immune system - 5.8 ng / kg body weight. Course of treatment - 5 daily drip intravenous infusion or subcutaneous injection. If necessary to repeat treatments at intervals of 2 weeks. The duration of infusion - 120-180 min.

Rules for the preparation of solutions

For solution for IV infusion contents of the ampoule (vial) was dissolved immediately before use in 1 ml of sterile 0.9% p-ra sodium chloride or water, d / and and bring the total volume of 100 ml 0.9% p-rum sodium chloride.

To achieve the estimated dose infusion the solution was diluted in the required amount (depending on the initial dose of the drug in the vial or bottle, and, accordingly, its concentration in the resulting solution) in 500 ml of 0.9% p-ra sodium chloride or 5% dextrose p-pa .

To obtain a solution for subcutaneous injection contents ampoule (vial) is dissolved in 0.5-1 ml of sterile 0.9% p-ra sodium chloride or water, d / and.

Side effect

Systemic reactions: in some cases - fever, headache, increased body temperature. These reactions continue for 2-3 h after injection, after which the temperature drops and side effects disappear.

Listed side effects are not a contraindication for continuation of treatment. In isolated cases: possible allergic reactions.

Contraindications
hypersensitivity to the drug;
septic shock;
severe fever;
pregnancy.

Pregnancy and lactation

The drug is contraindicated in pregnancy.

Cautions

If you experience severe side effects prescribed paracetamol, metamizol sodium, diphenhydramine, or a combination, you can choose to use corticosteroids.

Overdose

Currently, cases of drug overdose Betaleukin were reported.

Drug Interactions

Drug interactions drug Betaleukin not described.

Conditions and terms of

List B. The drug must be stored and transported at a temperature not exceeding 15 ° C. Shelf life - 2 years.