2010/12/17

Betasone

Release form, composition and packing Betasone 

Drops eye / ear in the form of transparent, colorless or slightly yellowish liquid. 1 mL betamethasone sodium phosphate (in terms of dry matter) 1 mg. Excipients: sodium phosphate dibasic, sodium chloride, Disodium EDTA (Trilon B), benzalkonium chloride, ortho-phosphoric acid (to pH 7.0-8.5), sodium hydroxide solution 1M, water d / and.

Clinico-pharmacological group: corticosteroids for topical use in ophthalmology and ENT practice.

Pharmacological action

Betamethasone - GCS provides local anti-inflammatory, antiallergic and vasoconstrictive action. Inhibits fibroblastic processes and the formation of collagen slows down the process of regeneration of the epithelium, inhibits the process of neovascularization in the inflammation, reduces the permeability of the vascular wall.

Statement

Eye diseases:
acute and chronic allergic and inflammatory diseases of the eye (including blepharitis, conjunctivitis, keratoconjunctivitis, scleritis, iritis, iridocyclitis);
Sympathetic ophthalmia;
Prevention and treatment of inflammatory complications after surgery on the eyeball and injuries.

Diseases of the ear:
allergic and inflammatory diseases of the external ear (including allergic otitis externa, chronic eczematous otitis externa, seborrheic otitis externa);
chronic skin disease ear canal, including Lichen simplex chronicus;
as an adjunct to therapy in infectious otitis (except otitis viral etiology).

Dosing regimen

In eye diseases at the beginning of drug therapy instill 1-2 drops into the lower conjunctival sac every 1-2 hours, followed by a gradual decrease in the multiplicity of applications, depending on the therapeutic effect.

In diseases of the ear medication is instilled with 3-4 drops into the ear canal every 2-3 hours after the desired effect should gradually reduce the multiplicity of the drug.

Side effect
On the part of the vision: the thinning or perforation of the cornea and sclera, increased intraocular pressure, posterior subcapsular cataract formation, secondary infection, the spread of Herpes simplex, dermatitis eyelid skin, itching, burning.
From the hearing organ: a burning sensation, pain and tingling in the ear, dermatitis, ear canal. Systemic reactions: suppression of adrenal function (when used in high doses).

Contraindications
fungal eye;
Acute viral infections of the eye (including acute superficial keratitis caused by Herpes simplex);
tuberculous eye disease;
thinning, or a defect of the epithelium of the cornea, sclera;
glaucoma;
fungal skin meatus;
tuberculous lesions ear;
Acute viral infections of the ear;
chronic otitis media or acute otitis media in history;
violation of the integrity of the eardrum;
Hypersensitivity to betamethasone or other ingredients.

Precautions should be used in the preparation for arterial hypertension, cardiac insufficiency, severe renal impairment and liver, nephrolithiasis.

Pregnancy and lactation

The drug during pregnancy is possible only if the expected benefits to the mother outweighs the potential risk to the fetus. If necessary, use during lactation breastfeeding should be discontinued.

Use in hepatic dysfunction

Caution should be used for drug violations expressed in liver function.

Use in renal impairment

Caution should be used for drug violations expressed in kidney function in nephrolithiasis.

Cautions

The drug Betazon should regularly monitor the intraocular pressure, lens status, since the possible development of steroid glaucoma and cataracts. Risk of side effects increases with duration of therapy, therefore use of the drug should be as short as possible (less than 5 days).

If you use contact lenses they must be removed before instillation of the drug and re-establish within 15 minutes after the procedure.

Use in pediatrics

The drug should be used with caution in children younger than 2 years, since the possible suppression of the adrenal cortex.

Effects on ability to drive vehicles and management mechanisms

Use caution when working with machinery and when driving.

Overdose

No cases of overdose Betazon were reported.

Drug Interactions

Drug interactions drug Betazon with other drugs has not been described.

Conditions and terms of

List B. The drug should be kept in the dark, place inaccessible to children, at temperatures from 0 ° to 25 ° C. Term life - 2 years.