2010/12/12

Atenolol

Release form, composition and packing

Tablets

1 tab. atenolol 50 mg.

Excipients: magnesium carbonate, corn starch, gelatin, sodium lauryl sulfate, talc, magnesium stearate.

Tablets

1 tab. atenolol 100 mg.

Excipients: magnesium carbonate, corn starch, gelatin, sodium lauryl sulfate, talc, magnesium stearate.

Clinico-pharmacological group: Beta1-blocker

Pharmacological action

Antihypertensive, antianginal, antiarrhythmic. Slowed heart rate (HR) and at rest and during exercise. Negative chronotropic effect manifested by 1 h, reaches a maximum after 2-4 h can be extended to 24 hours reduces cardiac output, systolic blood pressure and ddiastolicheskoe, reduces orthostatic tachycardia. Antihypertensive effect lasts 24 hours reduces the need for myocardial kislorode.Uvelichivaet survival of patients with myocardial infarction (lowers the frequency of ventricular arrhythmias and angina). Slightly reduces vital lung function, practically does not weaken the bronchodilatory effects of isoproterenol. Poorly crosses the blood-brain barrier, passes through the placenta and into breast milk. Practically not metabolized in the liver, kidneys by glomerular filtration.

Statement
hypertension,
angina,
Acute myocardial infarction (with stable hemodynamics)
Tachycardia: Sinus,
atrial,
ventricular paroxysmal and others,
extrasystole,
flutter and atrial fibrillation
hyperkinetic cardiac syndrome,
mitral valve prolapse,
neurocirculatory dystonia of hypertensive type;
Combination Therapy of hypertrophic cardiomyopathy
pheochromocytoma,
thyrotoxicosis,
essential tremor;
Migraine (prophylaxis).

Dosing regimen

Inside, before a meal, without chewing, and squeezed a small amount of liquid.

The dosage regimen set individually.

When hypertension - 25-50 mg dose, if necessary, 100-200 mg 1-2 times a day.

Coronary heart disease, cardiac arrhythmias tahisistolicheskih - 50 mg 1 time a day if necessary and well tolerated dose may be increased during the week to 100-200 mg / day.

For acute myocardial infarction with stable hemodynamic parameters - 12 hours - again 50 mg; further - 50 mg 2 times a day for 6-9 days (under the control of blood pressure, ECG, blood glucose).

When functional disorders of the cardiovascular system - 25 mg 1 time per day.

If the kidney function according to creatinine clearance: if clearance 15-35 ml / min - 50 mg / day (or 100 mg a day), less than 15 ml / min - 50 mg every other day (or 100 mg 1 time in 4 days); patients in hemodialysis - 25-50 mg / day immediately after dialysis.

In elderly patients the initial single dose of 25 mg (can be increased under the control of blood pressure, heart rate).

Side effect

The nervous system and sensory organs: fatigue, weakness, dizziness, headache, drowsiness or insomnia, nightmares, depression, anxiety, confusion, or momentary loss of memory, hallucinations, weakening the reactivity, paresthesia, seizures, visual disturbances, reduced secretion of saliva and tear fluid, conjunctivitis.

With the cardiovascular system and blood (hematopoiesis, hemostasis): bradycardia, palpitations, impaired myocardial conduction, AV block, arrhythmias, attenuation of myocardial contractility, heart failure, hypotension, syncope, Raynaud's phenomenon, vasculitis, chest pain, thrombocytopenia, agranulocytosis .

From the digestive tract: dryness of the mouth, nausea, vomiting, abdominal pain, diarrhea, constipation, liver function abnormalities.

With the respiratory system: dyspnea, laryngitis, and bronchospasm.

Allergic reactions: itching, rash, erythema, urticaria, psoriazopodobnye and degenerative skin changes.

Other: reversible alopecia, hyperhidrosis, cold extremities, myasthenia gravis, a weakening of libido, impotence, Peyronie's disease, changes in the activity of enzymes, bilirubin levels, withdrawal symptoms, hypothyroid condition, hypoglycemia.

Contraindications
hypersensitivity,
sinus bradycardia (heart rate <50 beats / min)
sinoatrial block,
sick sinus syndrome,
AV blockade II-III degree
hypotension (systolic blood pressure less than 90 mm Hg)
acute or chronic heart failure in the stage of decompensation,
cardiogenic shock,
violation of the peripheral circulation,
breast-feeding.

Pregnancy and lactation

Perhaps, if the effect of therapy outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.

Cautions

Limited to application at: diabetes, hypoglycemia, chronic obstructive pulmonary disease (emphysema, asthma), hepatic dysfunction and / or kidney disease, myasthenia gravis, depression, psoriasis, pheochromocytoma, metabolic acidosis, pregnancy, children (efficacy and safety are not defined) and old age.

Treatment is provided with regular medical supervision. Before starting therapy should be compensated heart failure. During the treatment to be monitored heart rate, blood pressure, blood glucose level (may adjust dose of antidiabetic drugs) and control over the appearance of symptoms of heart failure.

Be wary of during the drivers of vehicles and people, a profession which is associated with increased concentration. At the time of therapy is recommended to exclude alcohol intake. For more information, see the instructions for use.

Overdose

Symptoms: bradycardia, AV block II-III degree, heart failure, respiratory failure, hypotension, bronchospasm, hypoglycemia.

Treatment: gastric lavage and the appointment of adsorbing means; symptomatic treatment: atropine, isoprenaline, ortsiprenalin, cardiac glycosides, or glucagon, diuretic, pressor agents (dopamine, dobutamine, or norepinephrine), selective beta-adrenoceptor agonists, glucose solution (w / w), installation of artificial pacemaker. Perhaps dialysis.

Drug Interactions

Antiarrhythmic and anesthetic facilities reinforce cardiodepressive action (increased risk of developing bradycardia, arrhythmia, hypotension, heart failure). Reserpine, alpha-methyldopa, clonidine, guanfacine, cardiac glycosides potentiate the negative chrono-, Drome and bathmotropic effect, insulin and other antidiabetic funds - hypoglycemia. NSAIDs, estrogens, sympathomimetics, xanthines impaired hypotensive effect, flow, increase - sympatholytic, nitroglycerin, apressin and other antihypertensive drugs, antacids - slow down absorption. Cimetidine inhibits the metabolism. Prolongs the action of muscle relaxants antidepolyarizuyuschih, anticoagulant effect of coumarins. Three / tetracyclic antidepressants, antipsychotics, sedatives, hypnotics and alcohol potentiate CNS depression. Incompatible with MAO inhibitors.

Conditions and terms of

Store in a dark place at room temperature, but not more than 25g. S.