Release form, composition and packing Acetylcysteine-Hemofarm 

Effervescent tablets are round, white to yellow-white color, with a faint odor of sulfur.

1 tab.

NAC 100 mg.

- - 200 mg.

- - 600 mg.

Granules for solution for oral administration

Granules for making syrup

Granules for suspension for oral administration

Solution for intravenous solution for intramuscular injection and topical application.

Clinico-pharmacological group: Mucolytic drug.

Pharmacological action

Mucolytic agent liquefies phlegm and increases its volume, helps to loosen phlegm.

Action related to the ability of free sulfhydryl groups acetylcysteine break the intra-and intermolecular disulfide bonds of acid mucopolysaccharides of phlegm, which leads to depolymerization mukoproteinov and reduce the viscosity of sputum (in many cases this leads to a significant increase in sputum, which requires the contents of the bronchial aspirate).

Retains activity in purulent sputum.

No effect on the immune system.

Increases the secretion of less viscous sialomutsinov goblet cells, reduces adhesion of bacteria to the epithelial cells of the bronchial mucosa.

Stimulates mucosal cells of the bronchi, the secret which lyses fibrin. A similar effect is having on the secret, which is formed in inflammatory diseases of upper respiratory tract.

Has an antioxidant effect due to the presence of SH-groups that can neutralize the electrophilic oxidative toxins.

Protects the alpha 1-antitrypsin (an inhibitor of elastase) from the inactivating effects of HOCl - oxidant produced by myeloperoxidase activity of phagocytes.

Also has some anti-inflammatory action (due to suppression of free radicals and active oxygen-containing substances responsible for the development of inflammation in lung tissue).

cystic fibrosis,
lung abscess,
bronchial asthma,
atelectasis of the lung (due to blockage of bronchial mucous plug).
catarrhal and purulent otitis media,
sinusitis (facilitating a discharge of secretion).
removal of viscous secretions from the respiratory tract in post-traumatic and postoperative conditions.
Preparations for bronchoscopy
aspiration drainage.
irrigation of abscesses,
rinsing the nasal passages,
maxillary sinus lavage,
lavage of the middle ear;
treatment of fistulas,
operative field during operations on the nasal cavity and mastoid.

Dosing regimen

Inside. Adults - 200 mg 2-3 times a day in the form of granules, tablets or capsules.

Children 2-6 years - 200 mg 2 times daily or 100 mg 3 times daily in the form of water-soluble resin, under 2 years - 100 mg 2 times a day, 6-14 years - 200 mg 2 times a day.

In chronic diseases for several weeks: adults - 400-600 mg / day in 1-2 doses; children 2-14 years - 100 mg 3 times a day in cystic fibrosis - Children from 10 days to 2 years - 50 mg 3 times daily, 2-6 years - 100 mg 4 times a day, 6 years old - 200 mg 3 times daily in the form of water-soluble granules, effervescent tablets or capsules.

Inhalation. Aerosol therapy in ultrasonic devices spray 20 ml 10% solution or 2-5 ml of 20% solution in devices with pilot valve - 6 ml 10% solution.

The duration of inhalation - 15-20 min; multiplicity - 2-4 times a day.

In the treatment of acute average length of therapy - 5-10 days, with long-term therapy of chronic conditions, treatment - up to 6 months.

In the case of strong suction sekretoliticheskogo actions secret, and frequency of inhalation and the daily dose is reduced.

Intratracheally. Rinsing the bronchial tree in therapeutic bronchoscopy using 5-10% solution.

Topically. Buried in the ear canal and nasal passages of 150-300 mg (1 procedure).

Parenterally. Administered in / in (preferably drip or slow jet - for 5 min) or V / m. Adults - 300 mg 1-2 times a day. D

etyam from 6 to 14 years - 150 mg 1-2 times a day.

Children under 6 years of age preferred oral intake, children under 1 year of intravenous acetylcysteine is only possible by "life" readings in the hospital. In that case, if you still have indications for parenteral therapy, the daily dose for children under the age of 6 years should be 10 mg / kg body weight.

For iv injection solution was diluted with an additional 0.9% NaCl or 5% dextrose at a ratio of 1:1.

The duration of therapy is determined individually (no more than 10 days).

Patients older than 65 years - using the minimum effective dose.

Side effect

Nausea, vomiting, feeling of fullness, nasal bleeding, rash, tinnitus, drowsiness, fever. Rarely - dyspepsia (including heartburn). When aerosol therapy: the reflex cough, irritation of the respiratory tract, rhinorrhea, rarely - stomatitis. When i / m administration - a burning sensation at the injection site, long-term treatment - abnormal liver function and / or kidneys.


C care. Peptic ulcer and 12 duodenal ulcer (in the acute phase), esophageal varices, hemoptysis, pulmonary hemorrhage, phenylketonuria (for forms that contain aspartame), asthma (with / in the introduction the risk of bronchospasm), adrenal disease, liver and / or renal failure, hypertension.

Pregnancy and lactation

Use of the drug is prohibited.


When treating patients with diabetes need to take into account that the granules contain sucrose.

When working with the drug must be used glassware, avoid contact with metal, rubber, oxygen, easily oxidized materials.

With a shallow V / m and the introduction of the drug if hypersensitivity can occur easily and quickly passing a burning sensation, and therefore the drug should enter deeply into the muscle.

In patients with bronchoobstructive syndrome should be combined with bronchodilators


No information available.

Drug Interactions

Increases the (relative) effect of bronchodilators. Reduces the absorption of penicillins, cephalosporins, tetracyclines (the interval between doses must be at least 2 h). Pharmaceutically compatible with antibiotics and proteolytic enzymes, in contact with metal, rubber forms sulfides with a characteristic odor