Aciclovir Belupo

Release form, composition and packing Aciclovir Belupo 

Cream for external use only 5% of white, homogeneous, without mechanical impurities.
1 g of acyclovir, 50 mg

Other ingredients: propylene glycol, glyceryl monostearate and macrogol - 100 stearate mixture, cetostearyl alcohol (60% cetyl alcohol, stearyl alcohol 40%), mineral oil, petrolatum, sodium lauryl sulfate, hydrochloric acid, water.

Clinico-pharmacological group: Antiviral medication for external use

Pharmacological action

Acyclovir - antiviral drug of a group of synthetic analogues of acyclic purine nucleoside-dezoksiguanidina, a component of DNA.

Acyclovir is highly specific for Herpes simplex virus types 1 and 2, the virus that causes chickenpox and shingles (Varicella zoster); Epstein-Barr virus. Moderately active against the causative agent of cytomegalovirus infection.

Acyclovir penetrates directly into the virus-infected cells. Cells infected with the virus, produce virus thymidine kinase, which fosforeliruet acyclovir to atsiklovirtrifosfata. The latter interacts with the viral DNA polymerase, which synthesizes new viruses. Thus, a "defective" viral DNA, which leads to suppression of replication of new generations of viruses.


When applying the cream on intact skin: induction minimum; not detected in blood and urine. Affected skin: induction moderate.

skin infections caused by Herpes simplex virus types 1 and 2;
genital herpes;

Dosing regimen

Externally. The drug is applied to damaged skin 5 times a day (every 4 h) with a thin layer on the affected and bordering with skin. The cream is applied with a cotton swab or clean hands, to avoid further infection of affected areas. Therapy should continue until such time as the bubbles are formed crust, or until they are fully healed. Duration of treatment - at least 5 days, maximum - 10 days.

Side effect

Redness, dryness, peeling, burning, inflammation in contact with mucous membranes. Perhaps the development of atopic dermatitis.

Hypersensitivity to acyclovir or excipients of the drug.

Precautions: pregnancy, lactation, dehydration, kidney failure.

Pregnancy and lactation

Adequate and controlled clinical studies on the safety of the drug during pregnancy has not been carried out.

Used during pregnancy only possible, when the intended benefits to the mother outweighs the potential risk to the fetus.

During the period of treatment needed to resolve the issue of termination of breastfeeding.

Use in hepatic dysfunction

Precautions: renal impairment.


To achieve maximum therapeutic effect should start to use the drug as soon as possible after the beginning of infection (at the first signs of the disease: burning, itching, tingling, a feeling of tension and redness). The cream should not be applied to mucous membranes of the mouth and eyes, as the possible development of pronounced local inflammation.

Acyclovir does not prevent transmission of herpes infections, so the period of treatment must abstain from sexual intercourse, even in the absence of clinical manifestations.

Drug Interactions

May increase the effect, while the appointment of immunostimulant.

Conditions and terms of

At a temperature not exceeding 25 ° C.

Keep out of reach of children.

Shelf life 2 years.

Do not use after expiration date printed on the packaging.