Release form, composition and packing
Tablets, coated yellow-beige, longitudinal.
1 tab. ascorbic acid 200 mg Rutozide 50 mg calcium (in the form of carbonate) 200 mg.
Excipients: sodium karmelloza, microcrystalline cellulose, magnesium stearate. The composition of the shell: hypromellose, povidone, macrogol, talc purified, titanium dioxide, antifoam emulsion, dye - iron oxide yellow.
Clinico-pharmacological group: Complex vitamins with macro.
Pharmacological action
Combination drug pharmacological effect which is due to its constituent components. Ascorbic acid - is formed in the human body, and comes only with food.
Exerts metabolic effects. Possesses antiplatelet and antioxidant properties. Participates in the formation of tetrahydrofolic acid and synthesis of steroid hormones, collagen and procollagen. Regulates immunological reactions (activates the synthesis of antibodies, the C3 component of compliment, interferon), promotes phagocytosis, increases resistance to infections. Participates in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, reduces vascular permeability, reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid.
Inhibits the release and accelerates the degradation of histamine, inhibits the formation of prostaglandins and other mediators of inflammation and allergic reactions. Rutozide - angioprotective agent, a derivative of flavonoid, exhibits antioxidant and chelating activity.
Neutralizes the uncontrolled reaction of free radicals and peroxides, fatty acids, which lead to atherosclerotic changes and disrupt the function of cell membranes. Rutozide is inhibited activity of aldose reductase, reduces the concentration of fibrinogen in the blood, increases the elasticity of red blood cells, inhibits platelet aggregation in the blood and reduces its viscosity, improving blood rheology, particularly in the microcirculatory bed. Reduces the permeability of blood vessels, especially capillaries. Increases the tone of the walls of the veins.
Anti-inflammatory and antiallergic action. Promotes the deposition of ascorbic acid in tissues. Action Rutozide enhanced by ascorbic acid. Calcium is one of the most important macronutrient.
Is a major component of bone tissue, plays an important role in maintaining the electrolyte balance of the body and the normal functioning of many regulatory mechanisms. Causes normal blood clotting, normal nerve conduction and contractility of striated muscle.
Affects the activity of many enzymes and plays a role of mediator, through which chemical, physical or hormonal impulses are transformed into a specific biological effect. Calcium reduces the permeability of blood vessels, therefore, has anti-inflammatory, anti, anti and protivoekssudativnoe action, and also stimulates the protective functions of the body.
Pharmacokinetics
Data on the pharmacokinetics Askorutikal Forte is not available.
Statement
prevention and treatment of hypo-and avitaminosis P and C;
combined therapy and prevention of infectious diseases (including SARS and influenza);
the treatment of diseases involving violations of vascular permeability: varicose veins, edema of the lower extremities caused by chronic venous insufficiency, allergic diseases (hay fever, urticaria, photosensitivity).
Dosing regimen
The drug is taken orally. Adults with a preventive purpose: on 1 tab. 2 times a day, with the purpose of treatment: 2 tablets. 2 times a day. In pregnancy and during breastfeeding maximum daily dose - 2 tablets.
Children older than 5 years as a prophylactic and therapeutic purposes: on 1 tab. 1 time per day. Duration of treatment - 3-4 weeks, depending on the nature of the disease and treatment efficacy
Side effect
From the digestive system: very rarely - nausea, discomfort in the epigastrium.
Other: very rarely - an allergic reaction, headache.
Contraindications
hypercalcemia (including patients with hyperparathyroidism, hypervitaminosis D, multiple myeloma or bone metastases);
severe renal insufficiency;
Children up to age 5 years;
concurrent use of sulfonamides and aminoglycosides;
hypersensitivity to the drug.
Be wary of in the states, accompanied by hypercoagulability of blood and a tendency to thrombosis, acute thrombophlebitis, because of calcium content - with renal failure, sarcoidosis, kidney stone disease, diseases of the cardiovascular system in patients receiving cardiac glycosides.
Pregnancy and lactation
It should be used with caution in the drug during pregnancy and lactation. The need to use the drug during pregnancy and lactation doctor determines individually.
Use in renal impairment
Be wary of because of calcium content - with renal dysfunction, urolithiasis. Contraindicated in severe renal insufficiency.
Cautions
Patients with urolithiasis during treatment should consume plenty of fluids. Ascorbic acid in high doses can cause false-positive test results for the presence of glucose in the urine, as well as false-negative test results for the presence of occult blood in feces.
Effects on ability to drive vehicles and management mechanisms
The drug has no effect on the ability of driving and working with moving machinery.
Overdose
Symptoms: High doses of calcium taken by mouth to patients with renal insufficiency may lead to hypercalcemia, symptoms of which are lack of appetite, gastrointestinal disturbances, muscle weakness, polyuria, urolithiasis. Ascorbic acid in high doses can cause excessive excretion of oxalic acid in urine, crystallization of urate, citrate, diarrhea.
Treatment: removal of preparation, conduct of symptomatic therapy under medical supervision.
Drug Interactions
Calcium salts taken by mouth, reduce the absorption of tetracyclines, and fluorine (required interval of 3 hours between taking these drugs and calcium salts).
Vitamin D and parathyroid hormone to increase calcium absorption, while at the same time, calcitonin, corticosteroids reduce calcium absorption. High doses of calcium given simultaneously with cardiac glycosides (digoxin and strophanthin derivatives) potentiate their effect and can cause heart rhythm abnormalities. Thiazide diuretics increase the reabsorption of calcium and risk of hypercalcemia. High doses of calcium combined with vitamin D can weaken the effect of verapamil and other drugs that block calcium channels.
Ascorbic acid increases the absorption of drugs of the penicillin group, iron, reduces the clinical effect of heparin and indirect anticoagulants. At doses greater than 1 g / day may reduce the effectiveness of tricyclic antidepressants, phenothiazine derivatives, and may also cause increased serum concentrations of estrogens used simultaneously.
Conditions and terms of
The drug should be stored out of reach of children, protected from light, at a temperature not exceeding 25 ° C. Shelf life - 3 years.
Tablets, coated yellow-beige, longitudinal.
1 tab. ascorbic acid 200 mg Rutozide 50 mg calcium (in the form of carbonate) 200 mg.
Excipients: sodium karmelloza, microcrystalline cellulose, magnesium stearate. The composition of the shell: hypromellose, povidone, macrogol, talc purified, titanium dioxide, antifoam emulsion, dye - iron oxide yellow.
Clinico-pharmacological group: Complex vitamins with macro.
Pharmacological action
Combination drug pharmacological effect which is due to its constituent components. Ascorbic acid - is formed in the human body, and comes only with food.
Exerts metabolic effects. Possesses antiplatelet and antioxidant properties. Participates in the formation of tetrahydrofolic acid and synthesis of steroid hormones, collagen and procollagen. Regulates immunological reactions (activates the synthesis of antibodies, the C3 component of compliment, interferon), promotes phagocytosis, increases resistance to infections. Participates in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, reduces vascular permeability, reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid.
Inhibits the release and accelerates the degradation of histamine, inhibits the formation of prostaglandins and other mediators of inflammation and allergic reactions. Rutozide - angioprotective agent, a derivative of flavonoid, exhibits antioxidant and chelating activity.
Neutralizes the uncontrolled reaction of free radicals and peroxides, fatty acids, which lead to atherosclerotic changes and disrupt the function of cell membranes. Rutozide is inhibited activity of aldose reductase, reduces the concentration of fibrinogen in the blood, increases the elasticity of red blood cells, inhibits platelet aggregation in the blood and reduces its viscosity, improving blood rheology, particularly in the microcirculatory bed. Reduces the permeability of blood vessels, especially capillaries. Increases the tone of the walls of the veins.
Anti-inflammatory and antiallergic action. Promotes the deposition of ascorbic acid in tissues. Action Rutozide enhanced by ascorbic acid. Calcium is one of the most important macronutrient.
Is a major component of bone tissue, plays an important role in maintaining the electrolyte balance of the body and the normal functioning of many regulatory mechanisms. Causes normal blood clotting, normal nerve conduction and contractility of striated muscle.
Affects the activity of many enzymes and plays a role of mediator, through which chemical, physical or hormonal impulses are transformed into a specific biological effect. Calcium reduces the permeability of blood vessels, therefore, has anti-inflammatory, anti, anti and protivoekssudativnoe action, and also stimulates the protective functions of the body.
Pharmacokinetics
Data on the pharmacokinetics Askorutikal Forte is not available.
Statement
prevention and treatment of hypo-and avitaminosis P and C;
combined therapy and prevention of infectious diseases (including SARS and influenza);
the treatment of diseases involving violations of vascular permeability: varicose veins, edema of the lower extremities caused by chronic venous insufficiency, allergic diseases (hay fever, urticaria, photosensitivity).
Dosing regimen
The drug is taken orally. Adults with a preventive purpose: on 1 tab. 2 times a day, with the purpose of treatment: 2 tablets. 2 times a day. In pregnancy and during breastfeeding maximum daily dose - 2 tablets.
Children older than 5 years as a prophylactic and therapeutic purposes: on 1 tab. 1 time per day. Duration of treatment - 3-4 weeks, depending on the nature of the disease and treatment efficacy
Side effect
From the digestive system: very rarely - nausea, discomfort in the epigastrium.
Other: very rarely - an allergic reaction, headache.
Contraindications
hypercalcemia (including patients with hyperparathyroidism, hypervitaminosis D, multiple myeloma or bone metastases);
severe renal insufficiency;
Children up to age 5 years;
concurrent use of sulfonamides and aminoglycosides;
hypersensitivity to the drug.
Be wary of in the states, accompanied by hypercoagulability of blood and a tendency to thrombosis, acute thrombophlebitis, because of calcium content - with renal failure, sarcoidosis, kidney stone disease, diseases of the cardiovascular system in patients receiving cardiac glycosides.
Pregnancy and lactation
It should be used with caution in the drug during pregnancy and lactation. The need to use the drug during pregnancy and lactation doctor determines individually.
Use in renal impairment
Be wary of because of calcium content - with renal dysfunction, urolithiasis. Contraindicated in severe renal insufficiency.
Cautions
Patients with urolithiasis during treatment should consume plenty of fluids. Ascorbic acid in high doses can cause false-positive test results for the presence of glucose in the urine, as well as false-negative test results for the presence of occult blood in feces.
Effects on ability to drive vehicles and management mechanisms
The drug has no effect on the ability of driving and working with moving machinery.
Overdose
Symptoms: High doses of calcium taken by mouth to patients with renal insufficiency may lead to hypercalcemia, symptoms of which are lack of appetite, gastrointestinal disturbances, muscle weakness, polyuria, urolithiasis. Ascorbic acid in high doses can cause excessive excretion of oxalic acid in urine, crystallization of urate, citrate, diarrhea.
Treatment: removal of preparation, conduct of symptomatic therapy under medical supervision.
Drug Interactions
Calcium salts taken by mouth, reduce the absorption of tetracyclines, and fluorine (required interval of 3 hours between taking these drugs and calcium salts).
Vitamin D and parathyroid hormone to increase calcium absorption, while at the same time, calcitonin, corticosteroids reduce calcium absorption. High doses of calcium given simultaneously with cardiac glycosides (digoxin and strophanthin derivatives) potentiate their effect and can cause heart rhythm abnormalities. Thiazide diuretics increase the reabsorption of calcium and risk of hypercalcemia. High doses of calcium combined with vitamin D can weaken the effect of verapamil and other drugs that block calcium channels.
Ascorbic acid increases the absorption of drugs of the penicillin group, iron, reduces the clinical effect of heparin and indirect anticoagulants. At doses greater than 1 g / day may reduce the effectiveness of tricyclic antidepressants, phenothiazine derivatives, and may also cause increased serum concentrations of estrogens used simultaneously.
Conditions and terms of
The drug should be stored out of reach of children, protected from light, at a temperature not exceeding 25 ° C. Shelf life - 3 years.
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