Release form, composition and packing
Tablets, enteric-coated cover white or white with a yellowish tint, round, biconvex, with a faint odor of acetic acid on a cross-section of two layers are visible.
1 tab. acetylsalicylic acid 50 mg - - 100 m.
Excipients: microcrystalline cellulose, starch 1500, colloidal silicon dioxide (Aerosil), stearic acid. The composition of the shell: acrylic-out (methacrylic acid copolymer with ethyl acrylate 1:1, titanium dioxide, talc, triethyl citrate, silicon oxide, colloidal anhydrous, sodium bicarbonate, sodium lauryl sulfate), kopovidon, hydroxypropylcellulose (klutsel).
Clinico-pharmacological group: NSAID. Antiaggregant.
Pharmacological action
NSAIDs. Antiaggregant. The mechanism of action of aspirin is irreversible inhibition of COX, as a result, blocks the synthesis of thromboxane A2 and inhibited platelet aggregation. Aspirin is also anti-inflammatory, analgesic and antipyretic effect.
Pharmacokinetics
Suction
After oral acetylsalicylic acid absorbed from the upper part of the small intestine. Cmax plasma levels achieved after an average of 3 hours after taking the drug inside.
Metabolism
Acetylsalicylic acid undergoes partial metabolism in the liver with formation of less active metabolites.
Breeding
Excreted by the kidneys as unchanged or as metabolites. T1 / 2 of acetylsalicylic acid is about 15 min for metabolites - about 3 hours
Statement
prevention of acute myocardial infarction in the presence of risk factors (eg, diabetes mellitus, hyperlipidemia, hypertension, obesity, smoking, old age);
prevention of recurrent myocardial infarction;
unstable angina;
prevention of stroke (including patients with transient ischemic);
prevention of transient ischemic;
prevention of thromboembolism after surgery and invasive procedures on vessels (eg, coronary artery bypass surgery, carotid endarterectomy, arterio-venous bypass, angioplasty of the carotid arteries);
prevention of deep vein thrombosis and pulmonary embolism and its branches (eg, prolonged immobilization as a result of extensive surgery).
Dosing regimen
Tablets, taken orally, before eating, drinking plenty of fluids. The drug is designed for prolonged use. The duration of therapy is determined by your doctor. For suspected acute myocardial infarction appoint 100-200 mg / day (the first pill must be chewed for faster absorption). For the prevention of first mooted acute myocardial infarction in the presence of risk factors - 50-100 mg / day.
To prevent another heart attack, stroke and transient ischemic, thromboembolic complications after surgical operations or invasive studies in unstable angina - 100 mg / day. For the prevention of deep vein thrombosis and pulmonary embolism and its branches - 100-200 mg / day.
For secondary prevention of stroke and transient ischemic attacks - 50 mg / day (as part of combination therapy with other antiplatelet and Angioprotectors).
Side effect
From the digestive system: nausea, heartburn, vomiting, pain in the abdomen, erosive and ulcerative lesions of the mucous membrane of the stomach and duodenum (including perforation), gastrointestinal bleeding, elevated liver enzymes.
With the respiratory system: bronchospasm.
From the hemopoietic system: increased bleeding, rarely - anemia.
CNS: dizziness, ringing in the ears.
Allergic reactions: urticaria, angioedema, anaphylactic reaction.
Contraindications
erosive and ulcerative lesions of the gastrointestinal tract;
gastrointestinal bleeding;
hemorrhagic diathesis;
Bronchial asthma induced by intake of salicylates and NSAIDs;
"Aspirin triad" (Fernand-Widal triad: a combination of asthma, recurrent polyposis of the nose and paranasal sinuses and the intolerance of acetylsalicylic acid);
combined use with methotrexate 15 mg per week or more;
renal-hepatic failure;
I and III trimesters of pregnancy;
Lactation (breastfeeding);
age 18;
Hypersensitivity to acetylsalicylic acid, other drug compounds and other NSAIDs.
Precautions should be used in the preparation for a history of ulcers of the gastrointestinal tract or gastrointestinal bleeding, kidney and liver failure, asthma, chronic respiratory diseases, hay fever, nasal polyposis, allergic reactions to other drugs, to treat gout, hyperuricemia, in II trimester of pregnancy, in combination with methotrexate at a dose of less than 15 mg per week, with a deficit of vitamin K and glucose-6-phosphate dehydrogenase.
Pregnancy and lactation
The drug is contraindicated during pregnancy in the I and III trimester. The use of salicylates in high doses during the first 3 months of pregnancy is associated with an increased frequency of developmental defects of the fetus (the splitting of the upper palate, congenital heart disease).
In the II trimester salicylate may be given only on the basis of strict evaluation of the risk-benefit ratio. In the III trimester of pregnancy salicylates in high doses (300 mg / day) cause inhibition of labor, premature closure of the ductus arteriosus in the fetus, increased bleeding in the mother and fetus, and the appointment immediately before delivery may cause intracranial hemorrhage, especially in preterm infants. Salicylates and their metabolites in small amounts into breast milk.
Incidental taking of salicylates during lactation is not accompanied by the development of adverse reactions in children and does not require stopping breastfeeding. However, prolonged use of a drug or appointing him to a high dose of breast-feeding should be stopped immediately.
Use in hepatic dysfunction
With careful use in liver failure. Contraindicated in renal-hepatic failure.
Use in renal impairment
Be wary of renal failure. Contraindicated in renal-hepatic failure. Special instructions patient should use this medicine after consulting your doctor. Keep in mind that aspirin can trigger bronchospasm and cause bronchial asthma and other hypersensitivity reactions.
Risk factors are the presence of asthma history, hay fever, nasal polyposis, chronic respiratory system diseases, and allergic reactions to other drugs (eg, skin reactions, pruritus, urticaria).
Keep in mind that the application of acetylsalicylic acid during and after surgery may develop bleeding of varying severity. The use of aspirin in low doses can provoke the development of gout in susceptible patients (with decreased excretion of uric acid). In the application of acetylsalicylic acid in high doses, marked hypoglycemic effect, which must be borne in mind when assigning it to patients with diabetes receiving hypoglycemic medications.
When combined appointment of the SCS and salicylates should be aware that during treatment the level of salicylate in the blood decreases, and after withdrawal of GCS possible overdose of salicylates. Not recommended combination of acetylsalicylic acid and ibuprofen, as the latter affects the beneficial effect of aspirin on life expectancy. The combination of aspirin with anticoagulants, thrombolytic and antiplatelet drugs is accompanied by an increased risk of bleeding.
The combination of acetylsalicylic acid with methotrexate is accompanied by increased frequency of side effects from the hematopoietic system.
In combination with acetylsalicylic acid and alcohol increased the risk of gastrointestinal mucosal lesions and bleeding time prolongation. Excess doses of aspirin carries a risk of gastrointestinal bleeding.
Effects on ability to drive vehicles and management mechanisms
There were no effects of the drug's ability to drive vehicles and management mechanisms.
Overdose
Symptoms of an overdose of moderate severity: nausea, vomiting, tinnitus, hearing loss, dizziness, confusion.
Treatment: a reduction in dose. Symptoms of severe overdose: fever, hyperventilation, ketoacidosis, respiratory alkalosis, coma, cardiovascular and respiratory insufficiency, severe hypoglycemia.
Treatment: immediate hospitalization in a specialized department for emergency treatment - gastric lavage, determination of the acid-alkaline balance, alkaline and forced alkaline diuresis, hemodialysis, the introduction of solutions, activated charcoal, symptomatic therapy.
Tablets, enteric-coated cover white or white with a yellowish tint, round, biconvex, with a faint odor of acetic acid on a cross-section of two layers are visible.
1 tab. acetylsalicylic acid 50 mg - - 100 m.
Excipients: microcrystalline cellulose, starch 1500, colloidal silicon dioxide (Aerosil), stearic acid. The composition of the shell: acrylic-out (methacrylic acid copolymer with ethyl acrylate 1:1, titanium dioxide, talc, triethyl citrate, silicon oxide, colloidal anhydrous, sodium bicarbonate, sodium lauryl sulfate), kopovidon, hydroxypropylcellulose (klutsel).
Clinico-pharmacological group: NSAID. Antiaggregant.
Pharmacological action
NSAIDs. Antiaggregant. The mechanism of action of aspirin is irreversible inhibition of COX, as a result, blocks the synthesis of thromboxane A2 and inhibited platelet aggregation. Aspirin is also anti-inflammatory, analgesic and antipyretic effect.
Pharmacokinetics
Suction
After oral acetylsalicylic acid absorbed from the upper part of the small intestine. Cmax plasma levels achieved after an average of 3 hours after taking the drug inside.
Metabolism
Acetylsalicylic acid undergoes partial metabolism in the liver with formation of less active metabolites.
Breeding
Excreted by the kidneys as unchanged or as metabolites. T1 / 2 of acetylsalicylic acid is about 15 min for metabolites - about 3 hours
Statement
prevention of acute myocardial infarction in the presence of risk factors (eg, diabetes mellitus, hyperlipidemia, hypertension, obesity, smoking, old age);
prevention of recurrent myocardial infarction;
unstable angina;
prevention of stroke (including patients with transient ischemic);
prevention of transient ischemic;
prevention of thromboembolism after surgery and invasive procedures on vessels (eg, coronary artery bypass surgery, carotid endarterectomy, arterio-venous bypass, angioplasty of the carotid arteries);
prevention of deep vein thrombosis and pulmonary embolism and its branches (eg, prolonged immobilization as a result of extensive surgery).
Dosing regimen
Tablets, taken orally, before eating, drinking plenty of fluids. The drug is designed for prolonged use. The duration of therapy is determined by your doctor. For suspected acute myocardial infarction appoint 100-200 mg / day (the first pill must be chewed for faster absorption). For the prevention of first mooted acute myocardial infarction in the presence of risk factors - 50-100 mg / day.
To prevent another heart attack, stroke and transient ischemic, thromboembolic complications after surgical operations or invasive studies in unstable angina - 100 mg / day. For the prevention of deep vein thrombosis and pulmonary embolism and its branches - 100-200 mg / day.
For secondary prevention of stroke and transient ischemic attacks - 50 mg / day (as part of combination therapy with other antiplatelet and Angioprotectors).
Side effect
From the digestive system: nausea, heartburn, vomiting, pain in the abdomen, erosive and ulcerative lesions of the mucous membrane of the stomach and duodenum (including perforation), gastrointestinal bleeding, elevated liver enzymes.
With the respiratory system: bronchospasm.
From the hemopoietic system: increased bleeding, rarely - anemia.
CNS: dizziness, ringing in the ears.
Allergic reactions: urticaria, angioedema, anaphylactic reaction.
Contraindications
erosive and ulcerative lesions of the gastrointestinal tract;
gastrointestinal bleeding;
hemorrhagic diathesis;
Bronchial asthma induced by intake of salicylates and NSAIDs;
"Aspirin triad" (Fernand-Widal triad: a combination of asthma, recurrent polyposis of the nose and paranasal sinuses and the intolerance of acetylsalicylic acid);
combined use with methotrexate 15 mg per week or more;
renal-hepatic failure;
I and III trimesters of pregnancy;
Lactation (breastfeeding);
age 18;
Hypersensitivity to acetylsalicylic acid, other drug compounds and other NSAIDs.
Precautions should be used in the preparation for a history of ulcers of the gastrointestinal tract or gastrointestinal bleeding, kidney and liver failure, asthma, chronic respiratory diseases, hay fever, nasal polyposis, allergic reactions to other drugs, to treat gout, hyperuricemia, in II trimester of pregnancy, in combination with methotrexate at a dose of less than 15 mg per week, with a deficit of vitamin K and glucose-6-phosphate dehydrogenase.
Pregnancy and lactation
The drug is contraindicated during pregnancy in the I and III trimester. The use of salicylates in high doses during the first 3 months of pregnancy is associated with an increased frequency of developmental defects of the fetus (the splitting of the upper palate, congenital heart disease).
In the II trimester salicylate may be given only on the basis of strict evaluation of the risk-benefit ratio. In the III trimester of pregnancy salicylates in high doses (300 mg / day) cause inhibition of labor, premature closure of the ductus arteriosus in the fetus, increased bleeding in the mother and fetus, and the appointment immediately before delivery may cause intracranial hemorrhage, especially in preterm infants. Salicylates and their metabolites in small amounts into breast milk.
Incidental taking of salicylates during lactation is not accompanied by the development of adverse reactions in children and does not require stopping breastfeeding. However, prolonged use of a drug or appointing him to a high dose of breast-feeding should be stopped immediately.
Use in hepatic dysfunction
With careful use in liver failure. Contraindicated in renal-hepatic failure.
Use in renal impairment
Be wary of renal failure. Contraindicated in renal-hepatic failure. Special instructions patient should use this medicine after consulting your doctor. Keep in mind that aspirin can trigger bronchospasm and cause bronchial asthma and other hypersensitivity reactions.
Risk factors are the presence of asthma history, hay fever, nasal polyposis, chronic respiratory system diseases, and allergic reactions to other drugs (eg, skin reactions, pruritus, urticaria).
Keep in mind that the application of acetylsalicylic acid during and after surgery may develop bleeding of varying severity. The use of aspirin in low doses can provoke the development of gout in susceptible patients (with decreased excretion of uric acid). In the application of acetylsalicylic acid in high doses, marked hypoglycemic effect, which must be borne in mind when assigning it to patients with diabetes receiving hypoglycemic medications.
When combined appointment of the SCS and salicylates should be aware that during treatment the level of salicylate in the blood decreases, and after withdrawal of GCS possible overdose of salicylates. Not recommended combination of acetylsalicylic acid and ibuprofen, as the latter affects the beneficial effect of aspirin on life expectancy. The combination of aspirin with anticoagulants, thrombolytic and antiplatelet drugs is accompanied by an increased risk of bleeding.
The combination of acetylsalicylic acid with methotrexate is accompanied by increased frequency of side effects from the hematopoietic system.
In combination with acetylsalicylic acid and alcohol increased the risk of gastrointestinal mucosal lesions and bleeding time prolongation. Excess doses of aspirin carries a risk of gastrointestinal bleeding.
Effects on ability to drive vehicles and management mechanisms
There were no effects of the drug's ability to drive vehicles and management mechanisms.
Overdose
Symptoms of an overdose of moderate severity: nausea, vomiting, tinnitus, hearing loss, dizziness, confusion.
Treatment: a reduction in dose. Symptoms of severe overdose: fever, hyperventilation, ketoacidosis, respiratory alkalosis, coma, cardiovascular and respiratory insufficiency, severe hypoglycemia.
Treatment: immediate hospitalization in a specialized department for emergency treatment - gastric lavage, determination of the acid-alkaline balance, alkaline and forced alkaline diuresis, hemodialysis, the introduction of solutions, activated charcoal, symptomatic therapy.
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