2010/12/16

Baralgin M

Release form, composition and packing Baralgin M 

Tablets

1 tab. metamizol sodium 500 mg.

Solution for injection

1 ml. metamizol sodium 500 mg.

1 amp. metamizol sodium was 2.5

Capsules, rectal [for children], tablets [for children]

Clinico-pharmacological group: analgesic-antipyretic

Pharmacological action

NSAIDs, pyrazolone derivatives, mechanism of action is practically no different from other NSAIDs (non-selectively block COX and reduces the formation of Pg from arachidonic acid). Hinders the extra pain and proprioceptive impulses on beams Gaulle and Burdach, raises the threshold of excitability of thalamic centers in pain sensitivity, increases heat transfer. A distinctive feature is a minor manifestation anti-inflammatory effect, which causes a slight effect on water-salt metabolism (delay of Na + and water) and gastrointestinal mucosa.

Has analgesic, antipyretic and some antispasmodic (for the smooth muscle of urinary and biliary) effect.

The action develops within 20-40 minutes after ingestion and reaches a maximum after 2 hours

Statement
febrile syndrome (infectious and inflammatory diseases, insect bites - mosquitoes, bees, gadfly, and others, post-transfusion complications);

pain (mild to moderate severity):
neuralgia,
myalgia,
arthralgia,
biliary colic,
intestinal colic,
renal colic,
trauma,
burns,
decompression sickness,
zoster,
orchitis,
sciatica,
myositis,
postoperative pain,
headache,
toothache
algomenorrhea.

Dosing regimen

Oral, 250-500 mg 2-3 times per day, maximum single dose - 1 g daily - 3 g.

Single dose for children

2-3 years - 50-100 mg;

4-5 years - 100-200 mg

6-7 years - 200 mg

8-14 years - 250-300 mg

Multiplicity of purposes - 2-3 times a day.

V / m or / (especially in severe pain): adults - 250-500 mg 3 times a day.

The maximum single dose - 1 g daily - 2 years

Children designate the rate of 5-10 mg / kg 2-3 times per day.

Children under 1 year of medication is administered only in V / m. Injectable solution for injection should have their body temperature. Doses over 1 g should be administered IV.

You must have the conditions for antishock therapy.

The most common reason for the sharp decrease of blood pressure is too high rate of injection, in connection with which intravenous should be done slowly (at a rate not exceeding 1 ml / min), the position of the patient "lying", under the control of blood pressure, heart rate and the number of breaths.

Rectal use - for adults - 300, 650 and 1000 mg.

The dose for children depends on the child's age and the nature of the disease, it is recommended to use the children's candles to 200 mg:

from 6 months to 1 year - 100 mg;

from 1 to 3 years - 200 mg

from 3 to 7 years - 200-400 mg

8 to 14 years - 200-600 mg.

After the introduction of the suppository child should be in bed.

Side effect

With the urinary system: Renal, oliguria, anuria, proteinuria, interstitial nephritis, urine staining in red. Allergic reactions: urticaria (including the conjunctiva and mucous membranes of nose and throat), angioedema, in rare cases - malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), bronhospasticheskih syndrome, anaphylactic shock.

For part of the blood: agranulocytosis, leukopenia, thrombocytopenia.

Other: blood pressure reduction.

Local reaction: when i / m administration may infiltrate at the injection site.

Overdose.

Symptoms: nausea, vomiting, stomachodynia, oliguria, hypothermia, decreased blood pressure, tachycardia, dyspnea, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and / or liver failure, convulsions, paralysis of respiratory muscles.

Treatment: gastric lavage, saline laxatives, activated carbon, conducting forced diuresis, hemodialysis, during the development of seizures - in intravenous diazepam and speed of barbiturates.

Contraindications
hypersensitivity to components of ptreparata,
inhibition of blood (agranulocytosis, neutropenia, infectious or cytostatic)
hepatic and / or renal failure,
hereditary hemolytic anemia,
associated with deficiency of glucose-6-phosphate dehydrogenase,
"Aspirin" asthma,
anemia,
leukopenia,
pregnancy (especially in I trimester and in the last 6 weeks)
lactation.

C care. The neonatal period (up to 3 months), kidney (pyelonephritis, glomerulonephritis - including history), prolonged abuse of ethanol. In the intravenous in patients with systolic blood pressure below 100 mm Hg or circulatory instability (eg against myocardial infarction, multiple trauma, starting shock).

Pregnancy and lactation

Use of the drug is contraindicated, especially in the I trimester and in the last 6 weeks.

Be wary of pregnancy (especially in the first trimester and in the last 6 weeks).

When used in the medium therapeutic doses of pyrazolone derivatives are excreted in breast milk in very small amounts.

Cautions

In the treatment of children under 5 years of age and patients receiving cytotoxic drugs, receiving metamizol sodium should be done only under medical supervision. Intolerance occurs very rarely, but the threat of anaphylactic shock after iv injection is relatively higher than after administration of the drug inside.

In patients with atopic asthma and hay fever have an increased risk of allergic reactions.

In patients receiving metamizol sodium may develop agranulocytosis, in connection with which the detection of unmotivated rise in temperature, chills, sore throat, difficulty swallowing, stomatitis, as well as the development of the phenomena of vaginitis or proctitis require immediate removal of the drug.

With prolonged use is necessary to control the peripheral blood picture.

Never use to relieve acute pain in the abdomen (to determine the cause).

For IM injection is necessary to use a long needle. Possible staining of urine into the red due to excretion of metabolites (irrelevant).

Drug Interactions

Because of the high likelihood of developing a pharmaceutical incompatibility can not be mixed with other drugs in the same syringe.

Strengthens the effects of ethanol, the simultaneous application of chlorpromazine and other phenothiazine derivatives may lead to severe hyperthermia.

Radiopaque drugs, colloidal blood substitutes and penicillin should not be used during treatment with metamizol.

When concomitant administration of cyclosporine decreased concentration of the latter in the blood. Metamizol, displacing from its association with protein oral hypoglycemic drugs, indirect anticoagulants, corticosteroids and indomethacin, increase their activity. Phenylbutazone, barbiturates and other gepatoinduktory while appointing reduce the effectiveness of metamizol.