2010/06/07

TRIPHOSADENINE

International name:
Trifosadenin (Triphosadenine)

Group Affiliation:
Metabolic means

Description of the active substance (INN):
Trifosadenin

Dosage form:
lyophilisates for solution for intravenous solution for intravenous injection

Mode of action:
Metabolic means, has hypotensive and antiarrhythmic action, dilates coronary and cerebral arteries. It is a natural makroergicheskim connection. Formed in the body as a result of oxidation reactions and in the glycolytic breakdown of carbohydrates. Contained in many organs and tissues, but most of all - in skeletal muscle. It improves metabolism and energy supply of tissues. Split into ADP and inorganic phosphate, ATP releases great amounts of energy used for muscle contraction, protein synthesis, urea, metabolic intermediates, etc. In the future decay products are included in the resynthesis of ATP. Under the influence of ATP, a decrease in blood pressure and relaxation of smooth muscles, improves conducting nerve impulses in autonomic ganglia and the transfer of excitation from n.vagus on the heart, increasing myocardial contractility. ATP suppresses automaticity of the sine-atrial node and Purkinje fibers (blockade of Ca2 +-channels and increase permeability to K +).

Indications:
Supraventricular paroxysmal tachycardia (paroxysms). Previously, the drug used for the following indications (at present in connection with the low efficiency of the testimony below, are excluded): muscular dystrophy and atrophy, poliomyelitis, multiple sclerosis, coronary disease, postinfarction kardiomiodistrofiya, acute and chronic cardiovascular failure, obliterating artery diseases - "intermittent" claudication, Raynaud's disease, thromboangiitis obliterans (Buerger's disease), hereditary pigmentary retinal degeneration, uterine inertia.

Contraindications:
Hypersensitivity, acute myocardial infarction, hypotension, inflammatory lung disease.

Side effects:
Allergic reaction (itching, flushing of the skin). When a / m administration - headache, tachycardia, increased diuresis, hyperuricemia, with a present - nausea, skin flushing, headache, fatigue.

Dosage and administration:
V / m, in / in or / and. In the first days of treatment - a / m, 10 mg (1 ml of 1% solution) 1 every day, then the same dose 2 times per day or 20 mg 1 time a day. The course of treatment - 30-40 injections, re-rate - after 1-2 months. To treat supraventricular arrhythmias - a / c, 10-20 mg for 5-6 s (the effect occurs within 30-40 s), if necessary, may re-introduction of 2-3 min.

Cautions:
You can not enter in large doses in conjunction with cardiac glycosides.

Interaction:
Cardiac glycosides increase the risk of side effects (including arrhythmogenic action).