2010/06/07

TRIMEPERIDINE

Pharmacological action

Analgesic, derivative fenilpiperidina. Agonist of opioid receptors. Possesses strong analgesic effect. Reduces the perception of pain impulses CNS, inhibits reflexes. Drowse. Compared with morphine, to a lesser extent, inhibits the respiratory center, less exciting center of the vagus nerve and the vomiting center. Has antispasmodic effect on smooth muscles of internal organs and, at the same time, increases the tone and strengthens the reduction of the myometrium.


Pharmacokinetics

Quickly absorbed by any route of administration. Once inside C max in plasma is determined within 1-2 hours after i / v administration reduced the plasma concentration within 1-2 h. The binding to plasma proteins is 40%. Metabolised by hydrolysis with the formation meperidinovoy and normeperidinovoy acid followed by conjugation. In a small number of findings by the kidneys unchanged.


Statement

Pain syndrome with injuries, illnesses, in the postoperative period. Pain associated with spasm of smooth muscles of internal organs and blood vessels, including for stomach ulcers and duodenal ulcers, angina, myocardial infarction, intestinal, liver and renal colic, constipation diskineticheskih. In obstetrics used for pain relief and accelerate delivery. As part of sedation and during anesthesia as a means of antishock. Neuroleptanalgesia (in combination with neuroleptics).


Dosage regimen

Adults n / a, i / m 10-30 mg, by mouth - 25-50 mg, in the present - from 3-10 mg. Maximum dose: Inside - The single 50 mg daily 200 mg, n / a - single 40 mg daily 160 mg.

Children older than 2 years inside or parenterally, depending on age - at 3-10 mg.


Side effect

On the part of the digestive system: nausea, vomiting.

From the CNS: weakness, dizziness, euphoria, disorientation.


Contraindications

Respiratory depression, increased sensitivity to Trimeperidine.


Application of pregnancy and breastfeeding

It is used during childbirth indicated.


Cautions

Perhaps the development of addiction and drug dependence.

Opioid analgesics should not be combined with MAO inhibitors. Prolonged use of barbiturates or opioid analgesics stimulate the development of cross-tolerance.

In the period of treatment to avoid alcohol.

Do not use in children under 2 years.

Effects on ability to drive vehicles and management mechanisms

During the period of Trimeperidine not recommended to engage in activities that require attention, psychomotor speed responses.


Drug Interactions

With simultaneous use of other drugs, have a depressing effect on the CNS, possibly mutually reinforcing effects.

Against the background of systematic use of barbiturates, especially phenobarbital, may decrease the analgesic action of opioid analgesics.

Naloxone activates respiration, eliminating analgesia after application of opioid analgesics.

Nalorfin eliminates respiratory depression caused by opioid analgesics, while maintaining their analgesic action.