2010/06/07

TRIMETHADIONE

Pharmacological action

Antiepileptic drugs, a derivative oksazolidindiona. Increases the threshold of cortical seizures, without influencing the same time, the maximum convulsive manifestations in patients who received electroconvulsive therapy. Reduces the spread of focal activity and increases presynaptic inhibition in the spinal cord, but no effect on nerve transmission in the cerebral cortex. It reduces the frequency of peak-wave complexes, detected in the EEG at small epileptic seizures. Active metabolite Trimethadione - dimetadion - blocks the calcium channels of type T in the neurons of the hypothalamus.


Statement

Small epileptic seizures that are resistant to treatment with other medicines.


Dosage regimen

When administered an initial dose for adults is 300 mg 3-4 times / day. If necessary, the daily dose increased to 300 mg every week until the anticonvulsant effect (prevention of seizures), or to the development of toxic manifestations. The maximum daily dose - 2.4 PM

The children used a dose of 13 mg / kg 3 times / day.


Side effect

From the side of the central nervous system and peripheral nervous system: dizziness, drowsiness, headache, irritability, photophobia, day-blindness, scotoma, diplopia, seldom - change behavior, sleep disturbances, paresthesia, unusual tiredness or weakness, confusion, increased tonic-clonic convulsions, muscle weakness, including the lowering of the eyelids, double vision, difficulty in chewing, swallowing, speech and breathing, severe fatigue.

On the part of the digestive system: rarely - dyspeptic symptoms (including abdominal pain, anorexia), hiccups, hepatitis.

Other: instability of blood pressure, hair loss, unusual weight loss, allergic reactions, abnormal changes in body weight, swollen face, hands, ankles and feet, turbid urine, volchanochnopodobny syndrome.


Contraindications

Pregnancy, hypersensitivity to Trimethadione.


Application of pregnancy and breastfeeding

Trimethadione contraindicated in pregnancy.

In applying Trimethadione during pregnancy there is a risk of congenital malformations of the fetus.

In the period of treatment for women of childbearing age should use reliable contraception.

It is not known whether allocated Trimethadione with breast milk. Infants whose mothers received Trimethadione not registered negative action.


Cautions

Trimethadione not recommended until such time until you ineffectiveness less toxic anticonvulsants to prevent epileptic seizures.

Trimethadione not recommended for use in severe pathological changes in the blood, severe liver problems, and / or kidney disease of the optic nerve or retina, acute intermittent porphyria.

Prior to and during treatment require regular review of the peripheral blood, the study of the liver, kidney, ophthalmologic examination.

When skin rash Trimethadione should be lifted immediately. In patients with hypersensitivity to one of dionovyh anticonvulsants, may increase susceptibility to other drugs in this group.

For the cessation of therapy dose should be reduced gradually Trimethadione.

Effects on ability to drive vehicles and management mechanisms

In the period of treatment to avoid activities that require high concentration and quickness of psychomotor reactions.


Drug Interactions

With the simultaneous use of funds that have a depressant effect on the central nervous system, ethanol may be increased inhibitory action on the CNS.

At simultaneous application with anticholinesterase means possible to develop myasthenia.

With simultaneous application of acetazolamide may be increased acidosis, toxic effect on the organ of vision, disruption of distribution and excretion of the active metabolite Trimethadione.