Pharmacological properties: combined drug effect is due to the components in its composition. Omeprazole belongs to the antiulcer Drugs that inhibit the basal and stimulated secretion of hydrochloric acid in gastric parietal cells due to the specific blocking H + / K +-ATPase (proton pump). Antisecretory effect of omeprazole develops during the first hour after administration and lasts for days. Omeprazole due to its high lipophilicity easily penetrates the parietal cells of the stomach, is concentrated in them, and provides Cytoprotective effect. Inhibitory effect increases in the first 4 days of admission. Omeprazole does not affect the motility of the gastrointestinal tract.

Domperidone blocks peripheral dopamine receptors, eliminates the inhibitory effect of dopamine on the motor function of the gastrointestinal tract, in particular, stimulates motor-evacuatory activity of the stomach. Eliminates the nausea and hiccups, has the action of antiemetics. Poorly crosses the BBB, has virtually no effect on dopamine receptors in the brain.

INDICATIONS: Peptic ulcer of the stomach and duodenum in the absence of H. pylori, slow evacuation of stomach contents, Gastroparesis, reflux esophagitis, functional dyspepsia.

APPLICATION: capsules taken by mouth in whole, without disclosing and not liquid. The recommended dose and duration of treatment depends on the disease and set individually. The average recommended dose for adults - 1 capsule 1 time a day for 10-15 minutes before a meal (drink a glass of water).

Elderly patients and patients with renal insufficiency requires an individual approach in the selection of doses, but in many cases, dose adjustment is required.

CONTRAINDICATIONS: Hypersensitivity to the drug's components, gastrointestinal bleeding, mechanical intestinal obstruction, perforation of the stomach or intestine, prolaktinoma, during pregnancy and lactation, age 12 years.

SIDE EFFECTS: Most patients tolerate the drug well. Prolonged use may experience skin reactions (rash, pruritus, urticaria, polymorphous erythema), dryness of the mouth, diarrhea, constipation, intestinal colic, headache, photosensitivity, alopecia, Quincke's edema, dizziness, parastezii, drowsiness, insomnia, blurred vision, change in taste, agitation, depression, leukopenia, thrombocytopenia, pancytopenia, agranulocytosis, myalgia, arthralgia, bronchospasm, interstitial nephritis, very rarely - galactorrhea, gynecomastia. Domperidone may lead to development of extrapyramidal disorders, particularly in elderly patients.

SPECIAL PRECAUTIONS: before and after omeprazole therapy is necessary to endoscopy to exclude undiagnosed cases of malignant process, as treatment omeprazole can mask symptoms and delay the correct diagnosis.

Patients with chronic liver diseases should always (at least 1 time in 2 weeks) to conduct laboratory testing of blood for determining the activity of liver enzymes. In case of change of these indices taking the drug should be discontinued.

During the period of drug treatment need to be careful while driving or operating machinery.

INTERACTIONS: Antacids drugs slow down and reduce the absorption Limzera, so they should be applied no earlier than 2 hours after his admission.

Because the metabolism of omeprazole by the liver via the cytochrome P450, should carefully take it along with diazepam, phenytoin, warfarin, propranolol, prednisolone, theophylline (with omeprazole may reduce their elimination, which requires lower doses of these drugs). With simultaneous application of omeprazole and clarithromycin concentration in plasma increases.

Cimetidine and sodium bicarbonate reduces the bioavailability of domperidone.

Antiholinergicheskie drugs neutralize the action of domperidone.

OVERDOSAGE: Symptoms: drowsiness, disorientation, vomiting, tachycardia, extrapyramidal disorders.

Treatment: gastric lavage, the use of activated charcoal, symptomatic therapy.

Storage: Store in a dry place protected from light at 25 ° C.