2010/06/07

Bromhexine

International name:
Bromhexine (Bromhexine)

Group Affiliation:
Mucolytic tool

Description of the active substance (INN):
Bromhexine

Dosage form:
pills, drops for oral administration, injection, solution for oral, syrup, syrup [for children], tablets, pills [for children]

Mode of action:
Mucolytic (sekretoliticheskoe) tool, has expectorant and antitussive effect of the weak. Reduces the viscosity of sputum (depolymerized mukoproteinovye and mukopolisaharidnye fiber increases serous component of bronchial secretions) activates the ciliated epithelium, increases the volume and improves the expectoration of sputum. Promotes endogenous surfactant, providing the stability of alveolar cells in the process of respiration. The effect is manifested after 2-5 days of starting treatment.

Indications:
Diseases of the respiratory tract, accompanied by the difficulty of separation of viscous sputum: tracheobronchitis, bronchitis of various etiologies (including complicated by bronchiectasis), bronchial asthma, pulmonary tuberculosis, pneumonia (acute and chronic), cystic fibrosis. Remediation bronchial tree in the preoperative period and during treatment and diagnostic intrabronchial manipulation, prevention of accumulation in the bronchi of the thick viscous sputum after the operation.

Contraindications:
Hypersensitivity, peptic ulcer, pregnancy (I term), lactation, infancy (up to 6 years - for the tablet form). C care. Renal and / or hepatic insufficiency, bronchial diseases, accompanied by excessive accumulation of secretions in history - gastric bleeding.

Side effects:
Allergic reactions, nausea, vomiting, dyspepsia, aggravation of gastric ulcer and 12 duodenal ulcer, dizziness, headache, increased activity of "liver" transaminase (extremely rare). Overdosage. Symptoms: nausea, vomiting, diarrhea, dyspepsia. Treatment: artificial vomiting, gastric lavage (in the first 1-2 h after admission).

Dosage and administration:
Inside (syrup, tablets and pills - for children over 6 years, drops, solution for oral use), adults and children over 14 years - 8-16 mg 3-4 times a day. Children under 2 years - 2 mg 3 times daily, 2-6 years - 4 mg 3 times daily, 6-14 years - 8 mg 3 times a day. If necessary, the dose may be increased for adults up to 16 mg 4 times a day. By inhalation (solution for inhalation) for adults - to 8 mg for children older than 10 years - 4 mg, 2-10 years - 2 mg. Inhalation spend 2 times a day. The solution is diluted 1:1 with distilled water and heated to body temperature to prevent coughing. If bronchial obstruction before the inhalation is necessary to appoint a bronchodilator drugs. Bromhexine 8-drop: inside, adults and adolescents over 14 years - 23-47 cap 3 times a day for children 6-14 years of age and patients with body weight below 50 kg - to 23 cap 3 times a day, up to 6 years - 12 cap 3 times a day. The therapeutic effect may occur at 4-6 days of treatment. Parenteral (IM, n / k / v slowly over 2-3 minutes) - 2-4 mg 2-3 times a day. Solution for i / v injection should be diluted with Ringer's solution or sterile water for injection. Patients with renal insufficiency prescribe smaller doses or increase the interval between infusions.

Cautions:
In the treatment should take plenty of fluids, which increases the expectorant action of bromhexine. In children, treatment should be combined with postural drainage and vibration massage of the thorax, facilitates the removal of bronchial secretions. Note that in the Bromhexine 8-drop is ethanol (41 vol. %).

Interaction:
Not appointed concurrently with drugs that suppress the cough center (including codeine), because this makes it difficult expectoration attenuated sputum (accumulation of bronchial secretions in the airways). Incompatible with alkaline solutions. Bromhexine facilitated the penetration of antibiotics (amoxicillin, erythromycin, cephalexin, oxytetracycline ), sulfanilamide drugs in the bronchial secretion in the first 4-5 days of antimicrobial therapy.