2010/06/24

Azaphen

Composition, structure and packing

The tablets are yellowish-greenish color, ploskotsilindricheskie, with beveled; exception of marbling.

1 tab. pipofezin (in form of hydrochloride), 25 mg.

Excipients: potato starch, colloidal silicon dioxide (Aerosil), microcrystalline cellulose, lactose, povidone (polyvinylpyrrolidone low molecular medicine), magnesium stearate.

Clinico-pharmacological group: Antidepressants.

Pharmacological action

Tricyclic antidepressant of the group of indiscriminate capture of inhibitors of neuronal monoamines. Has timoanalepticheskoe and sedative effect.

The mechanism of antidepressant action linked to the indiscriminate inhibition of reverse neuronal capture of serotonin and norepinephrine, which leads to an increase in their concentration in the CNS. Almost does not have the m-anticholinergic activity and no effect on the activity of MAO. It has no cardiotoxic action.

Pharmacokinetics

Absorption

Quickly and completely absorbed from the gastrointestinal tract. Bioavailability - 80%. Time to reach C max - 2 hours

Distribution and Metabolism

Binding to plasma proteins - 90%. Metabolised in the liver to form inactive metabolites.

Withdrawal

T1 / 2 - 16 hours excreted mainly by the kidneys.

Statement
depressive disorders of mild to moderate severity (including depression with chronic somatic diseases).

Dosage regimen

The initial dose for adults is 25-50 mg in 2 divided doses (morning and lunch). With good endurance gradually increase the dose to 150-200 mg / day (3-4 reception, the last reception before going to sleep), in some cases - up to 400 mg / day. The optimum daily dosage - 150-200 mg, the maximum daily dose - 400-500 mg.

Upon reaching the desired effect of switching to maintenance doses - 25-75 mg / day.

The course of treatment - up to 1 year (at least 1-1.5 months).

Side effect
From the CNS: headache, dizziness.
On the part of the digestive system: nausea, vomiting.

Other: allergic reactions.

Contraindications
severe hepatic and / or renal failure;
simultaneous reception of MAO inhibitors;
Pregnancy
Lactation (breastfeeding);
Hypersensitivity to the drug.

Precautions should be prescribed the drug for chronic heart failure, myocardial infarction, ischemic heart disease, conditions after a stroke, infectious diseases, diabetes mellitus, children.

Pregnancy and lactation

The drug is contraindicated during pregnancy and lactation.

Application for violations of liver function

The drug is contraindicated in severe renal failure.

Application for violations of renal function

The drug is contraindicated in severe renal insufficiency.

Cautions

In the period of treatment prohibited use of alcohol.

Effects on ability to drive vehicles and management mechanisms

During the reception Azafena patients is not recommended to perform work that requires quick reaction (to drive vehicles and to perform other potentially dangerous activities).

Overdose

In case of overdose may gain side effects.

Treatment: perform symptomatically.

Drug Interactions

With simultaneous application Azafen enhances the effects of anticoagulants, ethanol, antihistamines and other drugs that depress the central nervous system. With simultaneous application Azafen reduces the effectiveness of anti-epileptic drugs.

Terms and Conditions of storage

List B. The drug should be stored in dry, light, reach of children, at a temperature not above 25 ° C. Period of validity - 5 years.