Composition, structure and packing
Tablets are white or nearly white, round, ploskotsilindricheskie, with beveled and risks.
1 tab. tetrametiltetraazabitsiklooktandion (mebikar) 500 mg.
Excipients: methylcellulose, calcium stearate.
Clinico-pharmacological group: tranquilizers (anxiolytic).
Pharmacological action
Anxiolytic (tranquilizers). Adaptol is similar in chemical structure to natural metabolites of an organism - its molecule consists of two methylated fragments of urea, comprising a bicyclic structure. Adaptol effect on the activity of structures within the of limbic-reticular complex, in particular, emotiogenic zone of the hypothalamus, and also has effects on all 4 major neurotransmitter systems: GABA-, choline-, serotonin-and adrenergic, helping them balance and integration, but has no peripheral adrenonegativnogo action.
Eliminates or reduces anxiety, anxiety, fear, inner emotional tension and irritability. Calming effect is not accompanied by miorelaxation and poor coordination of movements.
Do not reduce the mental and motor activity, so adaptol can apply during the workday or school. Do not create a good mood, feelings of euphoria.
Soporific effect does not, but increases the effects of hypnotic drugs and improves during sleep with his violations. Adaptol facilitates or removes nicotine abstinence. In addition to providing soothing nootropic effect. In clinical studies found that adaptol improves consistency, coherence, and speed of thinking, improves attention and mental abilities are not encouraging signs of productive psychopathological disorders: delirium, pathological emotional activity.
Pharmacokinetics
Absorption
Once inside adaptol well absorbed from the gastrointestinal tract (77-80%). Cmax of the active substance in the blood plasma obtained 0.5 h after ingestion. High concentrations of the active substance remains for 3-4 h, then gradually decreases.
Distribution
Up to 40% of applied dose is associated with erythrocytes. The rest is in the blood plasma in the free form, so the active substance is distributed freely throughout the body and readily passes cell membranes. Metabolism of active substance is not metabolized and does not accumulate in the body.
Withdrawal
Approximately 55-70% of applied dose excreted in the urine and the rest - with the feces as unchanged during the day.
Statement
neuroses and neurosis-like condition occurring with symptoms of irritability, emotional instability, anxiety and fear;
to improve the portability of neuroleptics and tranquilizers in order to eliminate the causes of their somatovegetativnyh and neurological side effects;
cardiodynia different genesis, not associated with CHD;
in combined therapy as a means of reducing the craving to smoke tobacco.
Dosage regimen
The drug, taken orally, regardless of food intake of 500 mg 2-3 times / day.
The maximum single dose of 3 grams daily - 10 g. The duration of treatment from a few days to 2-3 months. In the combined therapy as a means of reducing the craving to smoke tobacco, appoint 600-900 mg 3 times / day for 5-6 weeks. If time has not been adopted next dose, treatment continues in the previously assigned dose.
Side effect
When used in high doses: possible - allergic reaction and dyspeptic disorders (should stop taking the drug), lowering blood pressure and body temperature (normalized independently). Usually adaptol well tolerated.
Contraindications
Hypersensitivity to the drug's components.
Pregnancy and lactation
Adaptol well penetrates into all tissues and body fluids. Do not have a sufficient number of clinical observations on the use of the drug during pregnancy and lactation (breastfeeding), so appoint a drug is not recommended.
Cautions
Habituation, addiction and withdrawal symptoms to adaptol not installed. Patients should inform your doctor about any side effects that occur during drug treatment.
Effects on ability to drive vehicles and management mechanisms
There was no effect adaptol the ability to perform work that requires a high concentration of attention and speed of psychomotor reactions.
Overdose
Drug toxicity. In case of suspicion of overdose, call a doctor, to conventional methods of detoxication, including gastric lavage.
Drug Interactions
The simultaneous use of adaptol with neuroleptics, tranquilizers (including benzodiazepines), hypnotics, antidepressants and psychostimulants.
Terms and Conditions of storage
The drug should be stored out of reach of children, dry place. Shelf life - 4 years.
Tablets are white or nearly white, round, ploskotsilindricheskie, with beveled and risks.
1 tab. tetrametiltetraazabitsiklooktandion (mebikar) 500 mg.
Excipients: methylcellulose, calcium stearate.
Clinico-pharmacological group: tranquilizers (anxiolytic).
Pharmacological action
Anxiolytic (tranquilizers). Adaptol is similar in chemical structure to natural metabolites of an organism - its molecule consists of two methylated fragments of urea, comprising a bicyclic structure. Adaptol effect on the activity of structures within the of limbic-reticular complex, in particular, emotiogenic zone of the hypothalamus, and also has effects on all 4 major neurotransmitter systems: GABA-, choline-, serotonin-and adrenergic, helping them balance and integration, but has no peripheral adrenonegativnogo action.
Eliminates or reduces anxiety, anxiety, fear, inner emotional tension and irritability. Calming effect is not accompanied by miorelaxation and poor coordination of movements.
Do not reduce the mental and motor activity, so adaptol can apply during the workday or school. Do not create a good mood, feelings of euphoria.
Soporific effect does not, but increases the effects of hypnotic drugs and improves during sleep with his violations. Adaptol facilitates or removes nicotine abstinence. In addition to providing soothing nootropic effect. In clinical studies found that adaptol improves consistency, coherence, and speed of thinking, improves attention and mental abilities are not encouraging signs of productive psychopathological disorders: delirium, pathological emotional activity.
Pharmacokinetics
Absorption
Once inside adaptol well absorbed from the gastrointestinal tract (77-80%). Cmax of the active substance in the blood plasma obtained 0.5 h after ingestion. High concentrations of the active substance remains for 3-4 h, then gradually decreases.
Distribution
Up to 40% of applied dose is associated with erythrocytes. The rest is in the blood plasma in the free form, so the active substance is distributed freely throughout the body and readily passes cell membranes. Metabolism of active substance is not metabolized and does not accumulate in the body.
Withdrawal
Approximately 55-70% of applied dose excreted in the urine and the rest - with the feces as unchanged during the day.
Statement
neuroses and neurosis-like condition occurring with symptoms of irritability, emotional instability, anxiety and fear;
to improve the portability of neuroleptics and tranquilizers in order to eliminate the causes of their somatovegetativnyh and neurological side effects;
cardiodynia different genesis, not associated with CHD;
in combined therapy as a means of reducing the craving to smoke tobacco.
Dosage regimen
The drug, taken orally, regardless of food intake of 500 mg 2-3 times / day.
The maximum single dose of 3 grams daily - 10 g. The duration of treatment from a few days to 2-3 months. In the combined therapy as a means of reducing the craving to smoke tobacco, appoint 600-900 mg 3 times / day for 5-6 weeks. If time has not been adopted next dose, treatment continues in the previously assigned dose.
Side effect
When used in high doses: possible - allergic reaction and dyspeptic disorders (should stop taking the drug), lowering blood pressure and body temperature (normalized independently). Usually adaptol well tolerated.
Contraindications
Hypersensitivity to the drug's components.
Pregnancy and lactation
Adaptol well penetrates into all tissues and body fluids. Do not have a sufficient number of clinical observations on the use of the drug during pregnancy and lactation (breastfeeding), so appoint a drug is not recommended.
Cautions
Habituation, addiction and withdrawal symptoms to adaptol not installed. Patients should inform your doctor about any side effects that occur during drug treatment.
Effects on ability to drive vehicles and management mechanisms
There was no effect adaptol the ability to perform work that requires a high concentration of attention and speed of psychomotor reactions.
Overdose
Drug toxicity. In case of suspicion of overdose, call a doctor, to conventional methods of detoxication, including gastric lavage.
Drug Interactions
The simultaneous use of adaptol with neuroleptics, tranquilizers (including benzodiazepines), hypnotics, antidepressants and psychostimulants.
Terms and Conditions of storage
The drug should be stored out of reach of children, dry place. Shelf life - 4 years.
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