2010/06/24

Adiupressinum

Dosage form, composition and packaging

Nasal Drops - 0,1 mg / ml vial. 2,5 ml. Dezmopressin - 0,1 mg / ml.

Other ingredients: benzalkonium chloride, water for injection.

Pharmacological action

Dezmoprescin - a synthetic polypeptide analog vazoprescina - posterior pituitary hormone. Possesses strong antidiuretic effect, but the impact dezmopressina blood vessels and smooth muscle compared with vasopressin significantly weaker. Acts on blood clotting: enhances fibrinolysis by increasing the activity of factor VIII and the level of plasminogen activator in plasma, but the fibrinolytic properties dezmopressina clinically, as a rule, do not appear.

Dezmopressin, as a polypeptide, cleaved under the action of enzymes of the digestive tract, so it is introduced intranasally, and the impossibility of this route of administration (nasal tamponade, damage to mucous membranes) - sublingually. Dezmopressin well tolerated.

Statement

Diagnosis and treatment diabetes insipidus, temporary polyuria and polydipsia after surgery in the pituitary, the auxiliary treatment of enuresis, conduct tests on the concentration ability of the kidneys.

Dosage regimen

Dose was set individually. Usually they bury 1-4 drops of 0.01% p-ra in the nose or under the tongue every 12 hours in severe cases can be applied every 8 hours when enuresis appoint 1 drop at bedtime. When conducting tests on the concentration ability of the kidneys is introduced to children on a drop, and adults - to 2 drops.

Contraindications

Hypersensitivity to dezmopressinu, anury, edema of any etiology, heart failure, decreased osmotic pressure of blood plasma.

Side effect

Are rare and usually disappear after dose reduction. Possible severe headache, nausea, rhinitis, swelling of the mucous membrane of the nasal cavity, moderate increase in blood pressure, stomach pain, spastic nature, increased pain during menses.

Cautions

Administration of these drugs requires special monitoring for the following groups of patients: children and adolescents, the elderly, patients with disorders of water and electrolyte balance, a risk of increasing intracranial pressure. With caution is prescribed for violations of renal function and / or cardio-vascular diseases, fibrosis of the bladder.

Application for the study of concentration ability of the kidneys in children under 1 year should be carried out only in a hospital. With caution used during pregnancy. The drug is excreted in breast milk in quantities that do not affect the diuresis and hemostasis in children.

Drug Interactions

Antidiuretic effect of clofibrate increased dezmopressina, hlorpropamidom and indomethacin, attenuated gliburidom and carbamazepine. Dezmopressin may potentiate the action of other drugs that increase blood pressure.

Cases of lower osmotic pressure of blood plasma with the development of overhydration and anasarca. Treatment is symptomatic.

Storage conditions and expiry dates

In a dry, dark place at a temperature of 8-25 ° C.