2010/06/14

Naproxen

The international name:
Naproxen (Naproxen)

Group Affiliation:
NSAID

Description of the active substance (INN):
Naproxen

Dosage form:
tablets, coated tablets

Mode of action:
NSAID, has anti-inflammatory, analgesic and antipyretic effect associated with non-selective suppression of activity TSOG1 and TSOG2 regulating the synthesis of Pg.

Indications:
Inflammatory and degenerative diseases of the musculoskeletal system: rheumatoid, juvenile chronic, arthritic arthritis, ankylosing spondylitis (Bechterew's disease), osteoarthritis. Pain: myalgia, ossalgiya, neuralgia, arthralgia, lumbago, headache and dental pain, tendinitis, in oncology, post-traumatic and postoperative pain, accompanied by inflammation, tuberculosis,, adnexitis, childbirth (as analgesic and tocolytic agent). Infectious and inflammatory diseases of ENT organs with marked pain syndrome (consisting of combined therapy): pharyngitis, tonsillitis, otitis media. feverish syndrome with " colds and infectious diseases.

Contraindications:
Hypersensitivity, erosive and ulcerative lesions GIT (exacerbation), "Aspirin" triad (a combination of asthma, recurrent nasal polyposis, and paranasal sinuses and intolerances ASA and LS pirazolonovogo series), inhibition of bone marrow hematopoiesis, liver and / or renal failure, pregnancy, lactation, infancy (under 1 year). C care. CHF, children's age (16 years).

Adverse effects:
NSAID-gastropathy (gastric antral damage in the form of mucosal erythema, hemorrhage, erosions and ulcers). Nausea, vomiting, epigastric discomfort, skin rash, urticaria, angioedema, headache, drowsiness, tinnitus, dizziness, weakness, slow reaction rate; erosive-ulcerative lesions, etc. GIT, gastrointestinal bleeding and perforation, eosinophilic pneumonia, thrombocytopenia, granulocytopenia, aplastic anemia, hemolytic anemia, hearing loss, renal failure or pecheni.Peredozirovka. Symptoms: heartburn, indigestion, nausea, vomiting, drowsiness. Treatment: gastric lavage, activated charcoal - 0.5 g / kg. Dialysis is ineffective.

Dosage and administration:
Ext. Tablets should be taken as a whole, washed down with a liquid, can be taken with food. In the acute stage - at 0.5-0.75 g 2 times a day. The maximum daily dose - 1.75 PM For maintenance therapy - mean daily dose of 500 mg of 2 admission (in the morning and at night). In acute attack of gout, the first dose - 825 mg, then - 275 mg every 8 hours when algodysmenorrhea - in the first 500 mg, followed by 275 mg every 6-8 hours for 3-4 days. When a migraine - 500 mg. rectal suppositories is usually prescribed at night (1 suppository 0.5 g). If necessary, use of naproxen in high doses can be combined in the appointment of candles and tablets. Children aged 1 to 5 years - a daily dose of 2.5-5 mg / kg in 1-3 reception, treatment should not exceed 14 days. When juvenile arthritis in children older than 5 years of daily dose - 10 mg / kg. The preferred dosage form for children is a suspension.

Cautions:
If necessary, determine the 17-ketosteroids drug should be abolished for 48 h before the study. Need to monitor liver and kidney function, the composition of peripheral blood. Note that naproxen increases the bleeding time.

Interaction:
At the same time the appointment may cause a decrease diuretic effects of furosemide, the strengthening effect of indirect anticoagulants. Increase the toxicity of phenytoin, sulphonamides, methotrexate (blocks tubular secretion). Reduces the hypotensive effect of beta-blockers. Reduces excretion of Li + and increases its concentration in plasma. Antacids drugs containing Mg2 + and Al3 +, reduces the absorption of naproxen. myelotoxic drugs increase the expression gematotoksichnosti drug.