2010/06/14

DARSIL

Pharmacological properties: The active ingredient of the drug Darcy - silymarin, a substance from the seeds of plants Silybium marianum (thistle). Bioactive components of silymarin neutralizes free radicals in liver cells by converting them into less toxic compounds and interrupting the process of lipid peroxidation. It stabilizes cell membranes and prevents the further destruction of cellular structures of hepatocytes. In the damaged hepatocytes stimulates the synthesis of structural and functional proteins and phospholipids by specific stimulation of RNA polymerase A, prevent the loss of cell components (transaminases), accelerate the regeneration of liver cells. Inhibit penetration of hepatocytes hepatotoxic substances, in particular poison mushroom Amanita phalloides.

Improves the general condition of patients with liver disease, decrease subjective sensations (fatigue, feeling of heaviness in the right hypochondrium). Promotes normalization of biochemical indices of hepatic (transaminase activity, alpha-glyutamilaminotransferazy, alkaline phosphatase, bilirubin).

Darcy has a low absorption, which is characteristic of hydrophobic silymarin. Almost does not bind to plasma proteins. Biotransformation takes place in the liver, participates in the reactions of conjugation with the formation of sulfate and glucuronide. Excreted mainly in bile in the small intestine re-absorbed into the systemic circulation, making multiple attenuated entero-hepatic circulation. The half-life of about 6 hours Virtually no kummuliruet in the body.

INDICATIONS: chronic hepatitis of different etiology, fatty liver in treatment of liver cirrhosis.

Prevention of toxic chemicals (alcohol, medication) hepatic lesions.

APPLICATION: Darcy tablets are inside after a meal without chewing with a small amount of liquid. A single dose - 1-2 tablets (0,035-0,07 Mr. silymarin), multiplicity - 3 times a day (daily dose depends on the severity of the disease). The course of treatment - at least 3 months.

As a prophylactic take 2-3 tablets (0,07-0,105 Mr. silymarin) per day.

The daily dose for children is 5 mg / kg body weight in 2-3 reception. When the child's body weight over 14 kg as a prophylactic measure can be assigned to 2 tablets of the drug per day.

CONTRAINDICATIONS: Hypersensitivity to silymarin, chronic erosive and ulcerative diseases of the stomach in the acute phase.

SIDE EFFECTS: in some cases may be laxative effect.

Cautions: 4 weeks of the drug is necessary to take a break (approximately 1 week), and resume taking the drug.

During pregnancy and breastfeeding drug is used only if the benefits to the mother outweigh the risks to the fetus.

INTERACTION: shows the synergy in the combined use of drugs essential phospholipids. Several increases metabolism of drugs (reduces half-life), pass biotransformation in the liver.

OVERDOSE: unlikely because of the low toxicity and lack of cumulative effect. In acute poisoning - a pain in the epigastric region, nausea, vomiting, diarrhea.

Treatment: gastric lavage with activated charcoal suspension, enema.

Storage: Store in a dry, dark place at temperatures not above 25 ° C.