2010/06/16

D-Panthenol

Composition, structure and packing D-Panthenol 

The cream for external use only 5% of homogenous, white, with a specific smell. 1 g Panthenol 50 mg Excipients: ketomakrogol, tsetearil oktanoat, tsetanol, dimethicone, glyceryl monostearate, propylene glycol, metilparagidroksibenzoat, propilparagidroksibenzoat, purified water, flavoring Seaside.

Ointment for external use only 5% of a homogeneous, light yellow in color, with a characteristic smell of lanolin. 1 g Panthenol 50 mg. Excipients: anhydrous lanolin, white vaseline, liquid paraffin, isopropyl miristat, cholesterol, metilparagidroksibenzoat, propilparagidroksibenzoat, purified water.

Clinico-pharmacological group: The drug, which improves trophic and regeneration of tissues, for external use.

Pharmacological action D-Panthenol 
The drug, which improves tissue regeneration, for external use.

Panthenol - a derivative of pantothenic acid, which is water-soluble B vitamins, necessary as part of coenzyme A for the carbohydrate, protein and fat metabolism. Playing an important role in the processes of acetylation in gluconeogenesis, the release of energy from carbohydrates, the synthesis and cleavage of fatty acids, the synthesis of sterols and steroid hormones, acetylcholine.

Pantothenic acid is essential for maintaining normal function of the epithelium, increasing the need for it there is damaged skin or tissue, in this case, a local deficiency of pantothenic acid can make the local application of ointments D-Panthenol.

It stimulates the regeneration of the skin, normalizes cellular metabolism, increases the strength of collagen fibers. Effect of recycling, a weak anti-inflammatory, nourishes and softens the skin. Excipients enhance the therapeutic properties of the ointment.

Pharmacokinetics D-Panthenol 
 

Low molecular weight dexpanthenol, hydrophilicity and low polarity allow penetration of active substances in all layers of the skin. When used topically is rapidly absorbed and converted into pantothenic acid, binds to plasma proteins (mainly with beta-globulin and albumin).

Statement
Children - diaper dermatitis, scratches, minor irritation after exposure to the sun, ultraviolet and X-rays, to treat and prevent diaper rash;
cracked and sore nipples in nursing mothers;
compromising the integrity of the skin caused by mechanical, chemical, thermal factors, or after surgery (burns of different origin / including solar / scratches, abrasions, wounds, bedsores, poorly healing skin grafts, aseptic postoperative wounds);
inflammation of the skin, dermatitis, boils, sores of the lower extremities, skin care around traheostom, gastrostom, kolostom;
treatment and prevention effects of adverse effects on the skin of environmental factors (including cold, wind, humidity).

Dosage regimen D-Panthenol 

The cream or ointment applied thinly to the affected area, lightly rubbing, 2-4 times / day (more if necessary). In case of damage to the infected skin surface should be pre-treated with antiseptic. Nursing mothers grease nipple ointment after each feeding. Babies ointment applied after each change of underwear or water procedure.

Side effect

When applying for the indications and recommended doses side effects were not observed.

Contraindications

Perhaps: Hypersensitivity to the drug's components.

Pregnancy and lactation

Can be used when indicated.

Cautions D-Panthenol 

Treatment of trophic ulcers and poorly healing skin grafts should be under the supervision of a physician. Do not apply to the oozing surface.

Overdose D-Panthenol 

Currently, cases of overdosing D-Panthenol not reported.

Drug Interactions

Drug Interactions of the drug D-panthenol are not described.

Terms and Conditions of storage

The drug should be stored out of reach of children at or above 25 ° C. Shelf life Cream - 1.5 years, ointments - 2 years.