International name:
Tsiklopiroks (Ciclopirox)

Group Affiliation:

Description of the active substance (INN):

Dosage form:
vaginal cream, cream for topical application, nail polish, vaginal suppositories

Mode of action:
Antifungal broad-spectrum drugs. Active against: Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton verrucosum, Trichophyton tonsurans, Trichophyton quinckeanum, Trichophyton equinum, Trichophyton concentricum, Trichophyton epilans, Trichophyton ferrugineum, Trichophyton gallnae, Trichophyton schoenleinii, Trichophyton soudanense, Trichophyton terrestre, Trichophyton violaceum, Microsporum canis, Microsporum gypseum, Microsporum audouini, Microsporum langeroni, Microsporum nanum, Epidermophyton floccosum, Candida (Candida albicans, Candida tropicalis, Candida krusei, Candida parapsilosis, Candida pseudotropicalis, Candida lipolytica, Candida quiliermondii, Candida brumpti, Candida utilis, Candida viswanathii), Cryptococcus neoformans, Histoplasma capsulatum, Sporotrichum schenckii, Torulopsis glabrata, Blastomyces dermatidis, Paracoccidioides braziliensis, Saccharomyces cerevisiae, Torula Bergeri, Aspergillus fumigatus, Aspergillus flavus, Aspergillus niger, Penicillium chrysogenum, Penicillium notatum, Absidia corymbifera, Mucor miehei, Paecilomyces varioti, Fusarium solani, Madurella grisea , Madurella mycetomi, Allescheria boydii, Cladosporium carrionii, Cladosporium trichoides, Philophora jeanselmei, Philophora pedrosoi, Philophora gougeroti, Hormodendrum dermatidis, Pyrenochaeta romeroi, Leptosphaeria senegalensis. It has antibacterial activity against Gram-positive and most Gram-negative pathogens. Suppresses the development of mycoplasmas and Trichomonas.

Treatment and prevention of fungal infections of the skin and mucous membranes (including colored lichen, onychomycosis, fungal vaginitis, and vulvovaginitis).

Hypersensitivity, pregnancy, lactation, children's age (10 years).

Side effects:
Local reactions (rare): itching, burning or skin irritation, hyperemia and peeling skin around the affected nail; allergic reactions.

Dosage and administration:
Outwardly, vaginally. The solution is for external use or cream: applied to the affected area and gently rubbing it 2 times a day. Treatment should be undertaken before the disappearance of skin effects (usually 2 weeks). In order to prevent recurrences is recommended to continue treatment for a further 1-2 weeks after symptoms disappear. The prevention of mycosis powder for external use (powder) is poured into socks or shoes. In the treatment and prevention of vaginitis and vulvovaginitis are using vaginal formulations - cream for intravaginal application, vaginal suppositories or solution (in the form of douching). The solution: to use douching 0.2% solution of Single bottle with a tip 1 times a day for 5 days. Vaginal cream: 1 time per day in the evening, before bedtime injected deep into the vagina with an applicator attached single-use (1 dose - 5 g) . For each procedure using a new single-use applicator. To prevent re-infection should be further processed neighboring skin vagina (external genitalia until the anus). To do this, squeezing from a tube a small amount of cream, apply it on the processed area with a cotton swab. Treatment duration - 6 days, if necessary, treatment is continued until 14 days. Vaginal Suppositories: 1 suppository (100 mg) once a day for 3-6 days, depending on the severity of the disease. Do not exclude the possibility of "ping-pong" effect. In order to prevent re-infection should be simultaneous treatment of sexual partners. Treatment of onychomycosis: length - from 4 to 28 weeks, depending on the severity of the case, the average length - about 12 weeks. The solution should be applied several times a day cream - in the evening. In order to improve treatment should be changed regularly skive all material and nails to apply a protective bandage from the film (in the evening rubbing in a large number of nail cream, give it a little dry and the bandage, the bandage is removed in the morning and several times during the day rubbing a nail solution preparation). Varnish is applied thinly to the affected nail is 1 time per day during the first month after the day of the second - 2 times a week, the third - one day a week. Duration of treatment should not exceed 6 months. 1 time per week varnish removed using a conventional solvent or after a warm bath scouring its upper layer.

Avoid contact with mud and cream in his eyes. It is recommended that simultaneous treatment of sexual partners. During the treatment is not recommended to use cosmetic nail polish. With long-term external use of the drug may be the phenomenon of sensitization.

The effect of increasing systemic antifungal drugs.