2010/06/13

Trypsin

Trade name:
Daltseks-Trypsin

The international name:
Trypsin (Trypsin)

Group Affiliation:
Proteolytic topica

Description of the active substance (INN):
Trypsin

Dosage form:
lyophilisates for solution for injection and local application, lyophilisates for solution for local and external use, napkin treatments

Mode of action:
Endogenous proteolytic enzymes. Optimum action - at pH 7-9. When applied topically has anti-inflammatory, Burns, recycling and nekroliticheskoe action. Cleaves the necrotic tissue and fibrous education, promotes rejection of necrotic tissue liquefies pus and facilitates its separation, improves the process of regeneration of wounds. There is no change in the hemostatic system. In relation to the healthy tissue is inactive and is safe in relation to the presence of trypsin inhibitors (specific and nonspecific).

Indications:
Diseases of the respiratory tract, pleural empyema, pleural effusion, thrombophlebitis, periodontitis (inflammatory-dystrophic form), osteomyelitis, sinusitis, otitis media, iritis, iridocyclitis, hemorrhage into the anterior chamber of the eye, edema periorbital area after operations and injuries, burns, pressure sores, festering wounds (used topically).

Contraindications:
Hypersensitivity, decompensated chronic heart failure, pulmonary emphysema with respiratory insufficiency, and decompensated forms of pulmonary tuberculosis, liver, liver cirrhosis, pancreatitis, infectious hepatitis, hemorrhagic diathesis. You can not enter into the cavity bleeding, I / O and applied on the surface of ulcerated tumors.

Adverse effects:
Allergic reactions, hyperthermia, tachycardia. When i / m administration - pain, congestion at the injection site, when inhaled - irritation of the mucous membranes of the upper respiratory tract, hoarseness.

Dosage and administration:
V / m: adults - 5-10 mg 1-2 times a day for children - to 2.5 mg 1 time a day. For injection immediately before use diluted 5 mg of crystalline trypsin in 2.1 ml 0.9% NaCl solution or 0.5-2% solution of procaine. The treatment course - 6-15 injections. Applied also electrophoresis with trypsin: 1 procedure 10 mg of trypsin (dissolved in 15-20 ml of distilled water), injected with the negative pole. Inhaler: 5-10 mg in 2-3 ml 0.9% NaCl solution through a nebulizer or a bronchoscope. After inhalation rinse your mouth with warm water and washed his nose. Eye drops: 0.2-0.25% solution, which is prepared immediately before use. Intraplevralno: 1 time per day, 10-20 mg, dissolved in 20-50 ml 0.9% solution of NaCl. Locally: in the form of powder or a solution of trypsin amorphous, dry or necrotic wounds impose compresses (a solution prepared immediately before use: 50 mg of trypsin dissolved in 5 ml of sterile water or 0.9% solution of NaCl, in the treatment of purulent wounds - in 5 ml phosphate buffer). Intraplevralno: 50-150 mg for in 5-30 ml phosphate buffer solution, preferably after the introduction of frequent changes in body position, on day 2 after instillation released, usually attenuated exudate. Triple woven cloth from dialdegidtsellyulozy, soaked in trypsin, impose on the wound (after treatment) and fixed with bandage on the wound, leaving no more than 24 hours before using cloth moistened with distilled water or solution furacilinum. Time of complete cleansing wounds of necrotic tissue and pus - 24-72 h. If necessary, apply again.