2010/06/13

Clindamycin

Trade name:
Dalatsin

The international name:
Clindamycin (Clindamycin)

Group Affiliation:
Antibiotic Lincosamides

Description of the active substance (INN):
Clindamycin

Dosage form:
gel for external use, vaginal cream, vaginal suppositories

Mode of action:
Bacteriostatic antibiotic group Lincosamides, has a broad spectrum of activity, binds to the 50S ribosomal subunit of the membrane and inhibits protein synthesis in the microbial cell. In a number of gram-positive cocci may bactericidal action. It is active against Staphylococcus spp. (Including Staphylococcus epidermidis, producing and neprodutsiruyuschih penicillinase), Streptococcus spp. (Except Enterococcus faecalis), Streptococcus pneumoniae, Corynebacterium diphtheriae, Mycoplasma spp., Anaerobic and microaerophilic gram positive cocci (including Peptococcus spp. And Peptostreptococcus spp.), Clostridium perfringens, Clostridium tetani, Bacteroides spp. (Including Bacteroides fragilis and Prevotella melaninogenica), Fusobacterium spp., Propionibacterium spp., Eubakterium and Actinomyces israelii. Most strains of Clostridium perfringens susceptible to clindamycin, but other types of Clostridium spp. (Including Clostridium sporogenes, Clostridium tertium) are resistant to its action in this connection with infections caused by Clostridium spp., Recommended definition antibiotikogrammy. Between clindamycin and lincomycin there is cross-resistance.

Indications:
Vaginal Cream - vaginitis, caused by microorganisms sensitive to drugs. Gel - acne.

Contraindications:
Hypersensitivity, pregnancy trimester I (for vaginal cream).

Adverse effects:
Allergic reactions. Vaginal Cream - irritation at the site of application, cervicitis, vaginitis, the development of superinfection (fungal vaginitis). Gel - irritation (in place of application), contact dermatitis. When resorption is likely to develop systemic side effects, including in rare cases - pseudomembranous enterocolitis.

Dosage and administration:
Vaginal: vaginal cream administered in a single dose - 100 mg clindamycin (1 applicator) for the night, the treatment course - 3-7 days. Outwardly: gel for topical application is applied to the affected area 2-3 times a day.

Cautions:
Vaginal Cream is not recommended for use in conjunction with other intravaginal drugs.

Interaction:
Incompatible with solutions containing a complex of vitamins B, aminoglycosides, ampicillin, calcium gluconate and magnesium sulfate. Be antagonism with erythromycin.