2010/06/08

Glutamyl-Cystinyl-Glycine disodium

Trade name:
Glutoxim

International name:
Glutamyl-cystine-glycine disodium (Glutamyl-Cystinyl-Glycine disodium)

Group Affiliation:
Immunopotentiating tool

Description of the active substance (INN):
Glutamyl-cystine-glycine disodium

Dosage Form:
injection

Mode of action:
Immunopotentiating tool affects the intracellular processes of thiol exchange. The mechanism of action related to the influence on redox-state cells. And systemic immunomodulatory Cytoprotective action is determined by the new level of redox systems and the dynamics of protein phosphorylation in key signal-transmission systems and transkriptatsionnyh factors (NFkB and AP-1), primarily immunocompetent cells. Have different impacts on the normal (stimulation of proliferation and differentiation) and transformed (induction of apoptosis - genetically programmed cell death) cells. It has high tropic to the cells of the central organs and immune system, lymphoid tissue, strengthens the processes of erythropoiesis, lymphopoiesis and granulocyte-monocytopoiesis; activates the phagocytosis (including in immunodeficient states), the recovery in the peripheral blood levels of neutrophils, monocytes, lymphocytes, and functional activity of tissue macrophages. Has a stimulating effect on the cascade mechanism of phosphate modifications of the main protein signal-transmitting systems is the initiation of cytokines (including endogenous production interleykina1, interleykina6, TNF, erythropoietin), playback effects interleykina2 through induction of expression of its receptors.

Indications:
Secondary immunodeficiency states associated with radiation, chemical and infectious factors (prevention and treatment); restoration of immune responses and bone marrow hematopoiesis, increase resistance to a variety of pathological influences - infectious agents, chemical and / or physical factors (including intoxication, radiation), viral hepatitis (B and C), COPD (effectiveness of antibacterial therapy), prevention of postoperative septic complications.

Contraindications:
Hypersensitivity, pregnancy, lactation.

Side effects:
Subfebrilitet, tenderness at the injection site (perhaps with the introduction of 1-2 ml of 0.5% procaine solution).

Dosage and administration:
B / B, / m, n / k of 5-30 mg (depending on the nature and severity of the disease) every day. The course of treatment - 10 days, if necessary repeat after 1-6 months. To prevent designate a / m 5-10 mg / day.

Cautions:
To reduce pain n / a and i / m injection is introduced into the same syringe with 0.5% solution of procaine (1.2 ml).

Interactions:
Pharmaceutical compatible with water-soluble drugs.