Pharmacological action

Protivoprotozoyny drug. The mechanism of action involves a violation of the structure of DNA sensitive microorganisms.

It is active against Trichomonas vaginalis, Giardia lamblia, Entamoeba histolytica, as well as against some anaerobic bacteria (including Bacteroides spp., Clostridium spp., Fusobacterium spp. And anaerobic cocci).


Absorption and distribution

After taking the drug inside ornidazole well absorbed from the gastrointestinal tract. Bioavailability - 90%. C max is achieved in 1-2 hours

Plasma protein binding - at least 15%. Penetrates through the BBB.

Metabolism and excretion

T 1 / 2 - about 13 hours displayed in the form of metabolites by the kidneys (60-70%) and feces (20-25%), about 5% - unchanged.


- Trichomoniasis;

- Amoebiasis, amoebic dysentery, amoebiasis extraenteric (including amebic liver abscess);

- Giardiasis;

- Prevention of infections caused by anaerobic bacteria, with operations on the colon and gynecology.

Dosage regimen

If trichomoniasis adults appoint 500 mg 2 times / day for 5 days. The kids set the dose rate of 25 mg / kg 1 time / day once.

In amoebic dysentery in adults and children weighing over 35 kg, 1.5 g 1 time / day, body weight over 60 kg - 2 g / day. For children weighing less than 35 kg a daily dose set at the rate of 40 mg / kg body weight . The course of treatment - 3 days.

In other forms of amebiasis in adults and children over 12 years - 500 mg, children between the ages of 7 to 12 years - 375 mg, aged 1 to 6 years - 250 mg, up to 1 year - 125 mg. Multiplicity pattern 2 times / day (morning and evening), duration of therapy - 5-10 days.

When giardiasis in adults and children weighing over 35 kg - 1.5 to 1 g once / day for children weighing less than 35 kg - 40 mg / kg / day. Duration of therapy is 1-2 days.

For the prevention of infections caused by anaerobic bacteria, appoint 0.5-1 g before surgery and 0.5 g 2 times / day after surgery for 3-5 days.

Side effect

From the central nervous system and peripheral nervous system: headache, dizziness, impaired consciousness, tremor, rigidity, poor coordination of movements, convulsions, sensory or mixed peripheral neuropathy.

On the part of the digestive system: nausea, vomiting, diarrhea.


- Organic central nervous system disease;

- I trimester of pregnancy;

- Lactation;

- Hypersensitivity to the components of the drug.

Application of pregnancy and breastfeeding

The drug is contraindicated for use in the I trimester of pregnancy and lactation (breastfeeding).


In the treatment of trichomoniasis should always treat sexual partners.

The consumption of alcohol during treatment with the drug is not indicated disulfiramopodobnyh reactions (ornidazole did not inhibit atsetaldegidrogenazu).


Symptoms: epileptiform seizures, depression, neuritis of peripheral nerves.

Treatment: perform symptomatically, with convulsions - diazepam.

Drug interaction

When the joint application of ornidazole enhances the effects of indirect anticoagulants (coumarin derivatives), prolongs the effect of vecuronium bromide miorelaksiruyuschy.

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Drug prescription.

Terms and Conditions of storage

List B. The drug should be stored in a dry place protected from light and away from children at or above 25 ° C. Shelf life - 3 years.