2010/06/09

DAIVONEX

Pharmacological action

The drug for the treatment of psoriasis. Calcipotriol is an analog of vitamin D. It stimulates the morphological differentiation and inhibits proliferation of keratinocytes that lies at the basis of its therapeutic effect in psoriasis.

Calcipotriol is a potent inhibitor of activation of T-lymphocytes induced by interleukin I.

Effect of calcipotriol on calcium metabolism in 100 times weaker than vitamin D 3.


Pharmacokinetics

Transdermal absorption of calcipotriol, depending on the dose, from 1% to 5%. Calcipotriol undergoes rapid biotransformation in the liver with the formation of pharmacologically inactive metabolites.

T 1 / 2 is very short.


Statement

- Vulgar psoriasis (including chronic psoriasis of the scalp).


Dosage regimen

Ointment

For the adult maximum daily dose is 15 g, the maximum dose per week - less than 100 g ointment applied thinly to the affected skin 2 times a day. Therapeutic effect is usually observed after 1-2 weeks of starting treatment. Duration of treatment - no more than 6-8 weeks.

For children under the age of 12 years, the maximum dose per week is 1975 The ointment is applied a thin layer to affected skin 2 times a day.

For children aged 6 to 12 years maximum dose per week - no more than 1950 ointment applied thinly to the affected skin 2 times a day.

Cream

For the adult maximum daily dose is 15 g, the maximum dose per week - less than 100 g. The cream is applied thinly on the affected skin 2 times a day. The therapeutic effect is observed after 1-2 weeks of starting treatment. Duration of treatment - no more than 6-8 weeks.

Solution

For adults the maximum total dose per week is 60 ml. A small amount of solution is applied to the affected areas of the scalp 2 times per day (morning and evening).


Side effect

Dermatological reactions: possible local irritation, erythema and itching of the skin, seldom - dermatitis (including dermatitis and perioral skin when applying the solution), exacerbation of psoriasis, and in some cases - hyperpigmentation, photosensitivity.

On the part of metabolism: in some cases - hypercalciuria, hypercalcemia.

Allergic reactions: in some cases - angioedema in the face (when using the drug in solution).


Contraindications

- Diseases which are accompanied by violations of calcium metabolism;

- Hypersensitivity to the drug's components.

With care use in patients with hypercalcemia, hypercalciuria, hypervitaminosis D, nephrolithiasis in children in the appointment of the cream and the solution (under 6 years old - in the appointment of the ointment) in the absence of experience in the application; in patients over 65 years.


Application of pregnancy and breastfeeding

Do not use Dayvoneks during pregnancy and lactation. Safety of the drug during pregnancy and lactation not established. It is not known whether calcipotriol is allocated through breast milk.


Application for violations of liver function

No data


Application for violations of renal function

No data


Cautions

Patients should be informed of that before applying Dayvoneksa should consult with your doctor.

Do not apply ointment, lotion and solution of the drug on the skin.

To avoid skin contact person hands should be thoroughly cleaned after each use, ointments, creams or solution.

Hypercalcemia develops in excess of the maximum dose of calcipotriol per week. If you remove the drug concentration of calcium in the blood rapidly returning to normal.

In the case of solution with ointment or cream should be borne in mind that the total dose of calcipotriol should not exceed 5 mg per week, which corresponds to 60 ml and 40 g of cream or ointment or 40 mL and 60 g of ointment or cream (1 ml corresponds to 1 g 1 g ointment or cream).

Treatment Dayvoneksom can be combined with PUVA-therapy.

Effects on ability to drive vehicles and management mechanisms

Dayvoneks not affect the ability to drive motor vehicles and management mechanisms.


Overdose

Symptoms: when using the drug in doses exceeding the recommended may increase the concentration of calcium in the blood.

Treatment: removal of the drug.


Drug interaction

Dayvoneks should not be used in conjunction with drugs for topical use containing salicylic acid.


To the top

The drug is approved for use as a non-prescription medicines.


Terms and Conditions of storage

The drug should be stored at temperatures not above 25 ° C in the reach of children. Shelf-life creams and ointments for external application - 2 years, solution for outdoor applications - 3 years.