Composition, structure and packing
Effervescent tablets tasteful red orange round, smooth, marble-pale pink, hygroscopic.
1 tab. ascorbic acid 500 mg
Excipients: anhydrous citric acid, sodium bicarbonate, lactose anhydrous, orange flavor type Bolexo, macrogol 6000, acesulfame potassium, dye Allura Red AC, sorbitol.
Clinico-pharmacological group: Vitamin
Pharmacological action and pharmacokinetics
To cover the shortage of vitamin C, the metabolic regulating the redox processes, antioxidant.
Absorbed in the small intestine (duodenum, partly - in the ileum).
Excreted in the urine, faeces, sweat, breast milk. Smoking and the use of ethanol accelerated the destruction, dramatically reducing the reserves in the body.
It has antioxidative properties.
Regulates the transport of hydrogen in many biochemical reactions, and improves utilization of glucose in the citric acid cycle, participates in the formation of tetrahydrofolic acid and regeneration of tissues, the synthesis of steroid hormones, collagen and procollagen.
Supports normal capillary permeability. Activates proteolytic enzymes involved in the exchange of aromatic amino acid, pigments, and cholesterol, promotes the accumulation of glycogen in the liver.
Improves bile secretion, restores the function of exocrine pancreas and endocrine - Thyroid.
Regulates immunological reactions, promotes phagocytosis, increases resistance to infection.
Inflammatory and antiallergic action.
Statement
hypovitaminosis C
hemorrhagic diathesis,
kapillyarotoksikoz,
hemorrhagic stroke
haemorrhages (nasal, lung, uterine, etc.)
infectious diseases
intoxication
alcohol and infectious delirium,
acute radiation sickness,
posttranfuzionnye complications
liver disease (infectious hepatitis, chronic hepatitis and cirrhosis),
GI (Akhil, peptic ulcer, especially after the bleeding, enteritis, colitis, helminthic),
cholecystitis
adrenal insufficiency (Addison disease),
sluggishly healing wounds,
ulcers
fractures,
dystrophy,
physical and mental overload
pregnancy and lactation,
hemosiderosis,
melanoderma,
erythroderma,
psoriasis
common chronic dermatosis.
As an antioxidant
Atherosclerosis
asthma,
diffuse connective tissue disease (rheumatoid artirit,
systemic lupus erythematosus,
scleroderma) and others;
overdose of anticoagulants,
aconite poisoning, Anaesthesinum, aniline, antabusom, barbiturates, benzene, dichloroethane, potassium permanganate, methyl alcohol, arsenic, carbon monoxide, hydrocyanic acid, sulfanilamide, thallium, phenols, and quinine.
Dosage regimen
Adults: prophylactically - 500 mg.
In therapeutic purposes - on 1000mg.
Before taking tablets dissolve in about 150 ml of water.
Side effect
Gastrointestinal irritation (nausea, vomiting, diarrhea), hypertension, metabolic disorders, depression function insular apparatus of the pancreas (hyperglycemia, Glycosuria) and glycogen synthesis, reduces capillary permeability and deterioration of trophic tissue, thrombocytosis, giperprotrombinemiya, blood clots, erythropenia, neutrophilic leukocytosis, myocardial degeneration, damage to glomerular apparatus of the kidneys, allergic reactions (including anaphylactic shock); Propafenone formation of urinary stones, metabolic zinc, copper, increased excitability of the CNS, sleep disorders, the development of microangiopathies.
Contraindications
hypersensitivity
thrombophlebitis
propensity to thrombosis,
diabetes.
Pregnancy and lactation
No data are presented.
Cautions
During long-term treatment requires monitoring of renal function, blood pressure and glucose level (especially in the appointment of high-dose).
Ascorbic acid as a reducing agent, can distort the results of various laboratory tests (blood levels of glucose, bilirubin, transaminase activity, LDH).
Overdose
Data on predozirovke not represented.
Drug Interactions
Improves concentration in the blood to salicylates (increases the risk of crystalluria), ethinyl estradiol, benzylpenicillin and tetracycline, reduces oral contraceptives.
Decreases the anticoagulant effect of coumarin derivatives.
It improves the absorption in the intestine of iron preparations.
Increases total Cl of ethanol.
Preparations quinolinic series, calcium chloride, salicylates, corticosteroids for prolonged use deplete reserves of vitamin C.
Terms and Conditions of storage
In a dry place protected from light at room temperature.
Shelf life - 2 years.
Effervescent tablets tasteful red orange round, smooth, marble-pale pink, hygroscopic.
1 tab. ascorbic acid 500 mg
Excipients: anhydrous citric acid, sodium bicarbonate, lactose anhydrous, orange flavor type Bolexo, macrogol 6000, acesulfame potassium, dye Allura Red AC, sorbitol.
Clinico-pharmacological group: Vitamin
Pharmacological action and pharmacokinetics
To cover the shortage of vitamin C, the metabolic regulating the redox processes, antioxidant.
Absorbed in the small intestine (duodenum, partly - in the ileum).
Excreted in the urine, faeces, sweat, breast milk. Smoking and the use of ethanol accelerated the destruction, dramatically reducing the reserves in the body.
It has antioxidative properties.
Regulates the transport of hydrogen in many biochemical reactions, and improves utilization of glucose in the citric acid cycle, participates in the formation of tetrahydrofolic acid and regeneration of tissues, the synthesis of steroid hormones, collagen and procollagen.
Supports normal capillary permeability. Activates proteolytic enzymes involved in the exchange of aromatic amino acid, pigments, and cholesterol, promotes the accumulation of glycogen in the liver.
Improves bile secretion, restores the function of exocrine pancreas and endocrine - Thyroid.
Regulates immunological reactions, promotes phagocytosis, increases resistance to infection.
Inflammatory and antiallergic action.
Statement
hypovitaminosis C
hemorrhagic diathesis,
kapillyarotoksikoz,
hemorrhagic stroke
haemorrhages (nasal, lung, uterine, etc.)
infectious diseases
intoxication
alcohol and infectious delirium,
acute radiation sickness,
posttranfuzionnye complications
liver disease (infectious hepatitis, chronic hepatitis and cirrhosis),
GI (Akhil, peptic ulcer, especially after the bleeding, enteritis, colitis, helminthic),
cholecystitis
adrenal insufficiency (Addison disease),
sluggishly healing wounds,
ulcers
fractures,
dystrophy,
physical and mental overload
pregnancy and lactation,
hemosiderosis,
melanoderma,
erythroderma,
psoriasis
common chronic dermatosis.
As an antioxidant
Atherosclerosis
asthma,
diffuse connective tissue disease (rheumatoid artirit,
systemic lupus erythematosus,
scleroderma) and others;
overdose of anticoagulants,
aconite poisoning, Anaesthesinum, aniline, antabusom, barbiturates, benzene, dichloroethane, potassium permanganate, methyl alcohol, arsenic, carbon monoxide, hydrocyanic acid, sulfanilamide, thallium, phenols, and quinine.
Dosage regimen
Adults: prophylactically - 500 mg.
In therapeutic purposes - on 1000mg.
Before taking tablets dissolve in about 150 ml of water.
Side effect
Gastrointestinal irritation (nausea, vomiting, diarrhea), hypertension, metabolic disorders, depression function insular apparatus of the pancreas (hyperglycemia, Glycosuria) and glycogen synthesis, reduces capillary permeability and deterioration of trophic tissue, thrombocytosis, giperprotrombinemiya, blood clots, erythropenia, neutrophilic leukocytosis, myocardial degeneration, damage to glomerular apparatus of the kidneys, allergic reactions (including anaphylactic shock); Propafenone formation of urinary stones, metabolic zinc, copper, increased excitability of the CNS, sleep disorders, the development of microangiopathies.
Contraindications
hypersensitivity
thrombophlebitis
propensity to thrombosis,
diabetes.
Pregnancy and lactation
No data are presented.
Cautions
During long-term treatment requires monitoring of renal function, blood pressure and glucose level (especially in the appointment of high-dose).
Ascorbic acid as a reducing agent, can distort the results of various laboratory tests (blood levels of glucose, bilirubin, transaminase activity, LDH).
Overdose
Data on predozirovke not represented.
Drug Interactions
Improves concentration in the blood to salicylates (increases the risk of crystalluria), ethinyl estradiol, benzylpenicillin and tetracycline, reduces oral contraceptives.
Decreases the anticoagulant effect of coumarin derivatives.
It improves the absorption in the intestine of iron preparations.
Increases total Cl of ethanol.
Preparations quinolinic series, calcium chloride, salicylates, corticosteroids for prolonged use deplete reserves of vitamin C.
Terms and Conditions of storage
In a dry place protected from light at room temperature.
Shelf life - 2 years.
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